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Found 59 clinical trials
Featured trial
Do You Take Two Insulins to Treat Your Type 2 Diabetes?

> Metformin Januvia, Onglyza, Tradjenta, or Nesina. (DPP-4’s) Farxiga, Invokana, or Jardiance. (SGLT2’s) Rybelsus (Oral GLP-1) Participants may also be

insulin
hemoglobin a1c
continuous glucose monitoring
lantus
metformin
  • 24 views
  • 22 Oct, 2021
  • 1 location
Featured trial
A long-term 4+ year, double blind placebo controlled study to evaluate the effects of bexagliflozin on hemoglobin A1c in patients with type 2 diabetes and increased risk of cardiovascular adverse events

A long-term 4+ year, double blind placebo controlled study to evaluate the effects of bexagliflozin on hemoglobin A1c in patients with type 2 diabetes and increased risk of cardiovascular adverse events

  • 342 views
  • 08 Nov, 2020
  • 1 location
Accelerating COVID-19 Therapeutic Interventions and Vaccines 4 ACUTE (ACTIV-4A)

This is a randomized, open label, adaptive platform trial to compare the effectiveness of antithrombotic and additional strategies for prevention of adverse outcomes in COVID-19 positive inpatients

  • 283 views
  • 12 Jul, 2022
  • 100 locations
DAPAgliflozin Sodium Water glucosE EffecTs in Patients at High Cardiovascular Risk (DAPA-SWEET)

This study aims to elucidate the impact of SGLT2 inhibition on peripheral vascular function, renal function, fluid volume, neurohormonal activation and inflammatory/fibrotic pathways in patients

diabetes
hba1c
heart disease
hypertension
body mass index
  • 0 views
  • 25 Feb, 2022
Efficacy of Dapagliflozin in Diabetes Associated Peripheral Neuropathy (DINE)

DM, such strict glycemic control has not shown to improve diabetic peripheral neuropathy in Type 2 DM. There are only few animal studies conducted so far which have shown that the use of SGLT2

  • 0 views
  • 15 Jun, 2022
  • 1 location
Effects of Short-term Intensive De-escalation Therapy on Long-term Regimen Simplification (ESTIMATOR)

Despite advances in diabetes management, many patients with type 2 diabetes in China fail to achieve optimal glycemic control. One of the possible reasons is associated with the delay in therapeutic decision making that lags behind glycemic rise. The investigators design this study and presume that using vildagliptin and metformin …

  • 0 views
  • 26 Apr, 2022
  • 1 location
Dapagliflozin and Hepatic Glucose Metabolism

the aim of this study is to examine the role of autonomic nervous system in the increase in hepatic glucose production in response to glucosuria caused by inhibition of renal glucose uptake

Accepts healthy volunteers
  • 0 views
  • 23 Jul, 2022
  • 1 location
Pioglitazone and SGLT2 Inhibitors vs. DPP4 Inhibitors in Patients With Stroke

consent forms will be randomly assigned in a 1:1 ratio to receive either combination of pioglitazone and an SGLT2 inhibitor (empagliflozin or dapagliflozin or canagliflozin) vs. a DPP4 inhibitor. Primary

ischemic stroke
diabetes
insulin resistance
type 2 diabetes mellitus
glycosylated hemoglobin
  • 0 views
  • 24 Mar, 2022
  • 1 location
SGLT2 Inhibitor or Metformin as Standard Treatment of Early Stage Type 2 Diabetes (SMARTEST)

A real-world, nationwide, register-based, randomised trial (RRCT) comparing SGLT2 inhibitors with metformin as standard treatment in early typ 2 diabetes. An open-label trial addressing efficacy

dapagliflozin
metformin
sglt2
sglt2 inhibitor
  • 78 views
  • 09 Feb, 2022
  • 1 location
Preservation of Beta Cell Function in Pre-diabetes in Subject With Impaired Fasting Glucose (IFG) and Impaired Glucose Tolerance (IGT)

HYPOTHESIS: Impaired glucose tolerance (IGT) and impaired fasting glucose (IFG) have distinct pathophysiologic etiologies. Therefore, therapeutic interventions designed to correct the specific underlying pathogenic abnormalities in IGT and IFG will be required to optimally prevent the progressive beta cell failure and development of overt type 2 diabetes.

impaired glucose tolerance
dapagliflozin
Accepts healthy volunteers
fasting
pioglitazone
  • 39 views
  • 17 Sep, 2022
  • 1 location