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Found 22 clinical trials
Phase 1/2a Open-Label, Dose-Escalation, Multicenter, FIH, Consecutive-Cohort, Clinical Trial of BI-1808, a Monoclonal Antibody to TNFR 2 as a Single Agent and in Combination With Pembrolizumab (MK-3475) in Subjects With Advanced Malignancies (Keynote-D20)

iRECIST can be applied for efficacy assessment) and subjects with cutaneous T-cell lymphoma (CTCL), specifically Sézary Syndrome (SS) and mycosis fungoides (MF). The study will consist of 2 phases

  • 38 views
  • 19 Sep, 2022
  • 5 locations
IPH4102 Alone or in Combination With Chemotherapy in Patients With Advanced T Cell Lymphoma (TELLOMAK)

This is an open label, multi-cohort, and multi-center phase II study, which evaluates the clinical activity and safety of IPH4102 in Sezary Syndrome and Mycosis fungoides as single agent.

mycosis
mycosis fungoides
anaplastic large cell lymphoma
t-cell lymphoma
sezary syndrome
  • 61 views
  • 11 Jul, 2022
  • 46 locations
Mogamulizumab + Low-Dose Total Skin Electron Beam Tx in Mycosis Fungoides & Sézary Syndrome

The purpose of this study is to determine the efficacy of the combination of LD-TSEBT and mogamulizumab in patients with MF and SS. And to evaluate the secondary measures of clinical benefit of the combination therapy and to evaluate the safety and tolerability of the combination in patients with MF …

bone marrow procedure
mycosis
retinoids
phototherapy
immunosuppressive therapy
  • 19 views
  • 25 Apr, 2022
  • 1 location
Pembrolizumab in Combination With Gemcitabine in People With Advanced Mycosis Fungoides or Sézary Syndrome

The purpose of this study is to find out whether the combination of pembrolizumab and gemcitabine is an effective treatment for mycosis fungoides and Sézary syndrome.

chemotherapy regimen
erythropoietin
mycosis
sezary syndrome
prednisone
  • 0 views
  • 07 Jul, 2022
  • 7 locations
Dosing of Brentuximab Vedotin for Mycosis Fungoides, Sezary Syndrome Patients

The purpose of this study is to test any good and bad effects of the study drug called brentuximab vedotin at a lower dose than is FDA-approved.

mycosis
brentuximab
systemic steroids
sezary syndrome
prednisone
  • 115 views
  • 05 Mar, 2022
  • 8 locations
Mogamulizumab and Extracorporeal Photopheresis for the Treatment of Sezary Syndrome or Mycosis Fungoides

This phase Ib/II trial investigates the side effects of mogamulizumab and extracorporeal photopheresis and to see how well they work in treating patients with Sezary syndrome or mycosis

chemotherapy regimen
mycosis
human chorionic gonadotropin
cutaneous lymphoma
retinoids
  • 0 views
  • 10 Jul, 2022
  • 1 location
Naloxone Hydrochloride Study for Relief of Pruritus in Patients With MF or SS Forms of CTCL

pruritus in patients with the mycosis fungoides (MF) or Sézary syndrome (SS) Forms of Cutaneous T-cell Lymphoma (CTCL). This study will also determine if there is systemic absorption of the drug in a

mycosis
hysterectomy
skin biopsy
t-cell lymphoma
sezary syndrome
  • 0 views
  • 26 Mar, 2022
  • 19 locations
A Phase II Study of Combination Extracorporeal Photopheresis (ECP) and Mogamulizumab in Erythrodermic CTCL

This phase II trial studies the effect of extracorporeal photopheresis (ECP) and mogamulizumab in treating patients with erythrodermic cutaneous T cell lymphoma (CTCL), a type of skin lymphoma. CTCL is a rare type of cancer that begins in the white blood cells called T cells. Erythrodermic is a widespread red …

mycosis
bone marrow procedure
serum pregnancy test
sezary syndrome
measurable disease
  • 0 views
  • 20 Sep, 2022
  • 1 location
Pembrolizumab in Treating Patients With Stage IB-IV Mycosis Fungoides

This phase II trial studies how well pembrolizumab works in treating patients with stage IB-IV mycosis fungoides. Antibodies, such as pembrolizumab, may interfere with the ability of cancer cells to grow and spread.

solid tumors
erythropoietin
mycosis
platelet count
systemic therapy
  • 9 views
  • 10 Apr, 2022
  • 1 location
Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma

This randomized phase I/II trial studies the best dose and side effects of durvalumab and to see how well it works with or without lenalidomide in treating patients with cutaneous or peripheral T cell lymphoma that has come back and does not respond to treatment. Monoclonal antibodies, such as durvalumab, …

chemotherapy regimen
anticoagulants
mycosis
cutaneous lymphoma
brentuximab
  • 64 views
  • 25 Mar, 2022
  • 1 location