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Found 17 clinical trials
Resminostat for Maintenance Treatment of Patients With Advanced Stage Mycosis Fungoides (MF) or S zary Syndrome (SS)

The purpose of this study is to determine whether resminostat will be able to delay or prevent worsening of disease in patients with advanced stage mycosis fungoides or Szary Syndrome that have recently achieved disease control with previous systemic therapy.

resminostat
renal function test
bexarotene
sezary syndrome
systemic therapy
  • 898 views
  • 27 Jan, 2021
  • 92 locations
IPH4102 Alone or in Combination With Chemotherapy in Patients With Advanced T Cell Lymphoma

This is an open label, multi-cohort, and multi-center phase II study, which evaluates the clinical activity and safety of IPH4102 in Sezary Syndrome and Mycosis fungoides as single agent.

anaplastic large cell lymphoma
skin biopsy
t-cell lymphoma
angioimmunoblastic t-cell lymphoma
skin lesion
  • 26 views
  • 26 Jan, 2021
  • 36 locations
Study of Alemtuzumab to Treat Advanced Mycosis Fungoides/Sezary Syndrome

The investigators designed a compassionate basis phase II study for refractory/relapsed mycosis fungoides/Sezary syndrome consisting of alemtuzumab (Campath) for primary evaluation of

renal function test
sezary syndrome
mycosis fungoides and sezary syndrome
campath
mycosis
  • 54 views
  • 07 Nov, 2020
  • 1 location
Dosing of Brentuximab Vedotin for Mycosis Fungoides Sezary Syndrome Patients

The purpose of this study is to test any good and bad effects of the study drug called brentuximab vedotin at a lower dose than is FDA-approved.

cancer
systemic steroids
immunomodulator
sezary syndrome
adrenal insufficiency
  • 24 views
  • 27 Jan, 2021
  • 9 locations
Mogamulizumab + Low-Dose Total Skin Electron Beam Tx in Mycosis Fungoides & S zary Syndrome

The purpose of this study is to determine the efficacy of the combination of LD-TSEBT and mogamulizumab in patients with MF and SS. And to evaluate the secondary measures of clinical benefit of the combination therapy and to evaluate the safety and tolerability of the combination in patients with MF …

gilbert's syndrome
t-cell lymphoma
metastatic tumor
antibiotic therapy
total skin electron beam therapy
  • 17 views
  • 24 Jan, 2021
  • 1 location
Naloxone Hydrochloride Study for Relief of Pruritus in Patients With MF or SS Forms of CTCL

This multi-center, double-blind, vehicle-controlled, randomized crossover design study will evaluate the safety and efficacy of topically applied naloxone lotion, 0.5%, for the treatment of pruritus in patients with the mycosis fungoides (MF) or Szary syndrome (SS) Forms of Cutaneous T-cell Lymphoma (CTCL). This study will also determine if there is …

naloxone hydrochloride
hysterectomy
skin biopsy
t-cell lymphoma
sezary syndrome
  • 0 views
  • 17 Feb, 2021
  • 31 locations
Pembrolizumab in Treating Patients With Stage IB-IV Mycosis Fungoides

This phase II trial studies how well pembrolizumab works in treating patients with stage IB-IV mycosis fungoides. Antibodies, such as pembrolizumab, may interfere with the ability of cancer cells to grow and spread.

metastatic tumor
direct bilirubin
measurable disease
metastases
platelet count
  • 1 views
  • 01 Mar, 2021
  • 1 location
Interleukin-15 (IL-5) in Combination With Avelumab (Bavencio) in Relapsed/Refractory Mature T-cell Malignancies

Background Some T-cell lymphomas and leukemias do not respond to standard treatment. Researchers hope to develop a treatment that works better than current treatments. Objective To test if interleukin (IL-5) combined with avelumab is safe and effective for treating certain cancers. Eligibility People ages 18 and older with relapsed T-cell …

anaplastic large cell lymphoma
t-cell lymphoma
angioimmunoblastic t-cell lymphoma
measurable disease
pet scans
  • 18 views
  • 15 Feb, 2021
  • 1 location
Durvalumab With or Without Lenalidomide in Treating Patients With Relapsed or Refractory Cutaneous or Peripheral T Cell Lymphoma

This randomized phase I/II trial studies the best dose and side effects of durvalumab and to see how well it works with or without lenalidomide in treating patients with cutaneous or peripheral T cell lymphoma that has come back and does not respond to treatment. Monoclonal antibodies, such as durvalumab, …

anaplastic large cell lymphoma
skin biopsy
t-cell lymphoma
monoclonal antibody therapy
cutaneous lymphoma
  • 60 views
  • 27 Feb, 2021
  • 4 locations
Romidepsin and Lenalidomide in Treating Patients With Previously Untreated Peripheral T-Cell Lymphoma

The purpose of this study is to evaluate how safe and effective the combination of the study drugs romidepsin and lenalidomide is for treating patients with peripheral t-cell lymphoma (PTCL) who have not been previously treated for this cancer. Currently, there is no standard treatment for patients with PTCL; the …

anaplastic large cell lymphoma
hysterectomy
hdac inhibitor
t-cell lymphoma
angioimmunoblastic t-cell lymphoma
  • 131 views
  • 24 Jan, 2021
  • 5 locations