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Found 68 clinical trials
Effect of Raised Head of the Bed on Lying Blood Pressure in Autonomic Failure

Many persons with autonomic failure often have high blood pressure when lying down (supine hypertension). This study is exploring the impact of decreased venous return to the heart (achieved by raising the head of the bed) to lessen supine blood pressure. If decreased venous return to the heart is effective …

  • 03 Oct, 2021
  • 1 location
12-week Exercise Intervention Program Versus Observation in Early Stage Breast Cancer Patients on the Impact on Mental Health, Quality of Life and Immune Markers

Exercise in early breast cancer patients has the potential to improve depression, anxiety, fatigue, quality of life and even survival. The effects of exercise may come about by way of changes in weight, immune markers and telomere length, but data on this so far has not been conclusive. To better …

adjuvant chemotherapy
breast carcinoma
breast cancer staging
cancer surgery
  • 03 Mar, 2022
  • 3 locations
Total Neoadjuvant Treatment Without Surgery For Locally Advanced Rectal Cancer (NO-CUT)

NO-CUT is a one-stage phase II trial seeking to establish whether an oxaliplatin-based chemotherapy preceding standard neo-adjuvant fluoropyrimidines-based chemo radiotherapy, can safely spare demolitive surgical intervention in patients with operable rectal cancer, without increasing the risk of distant relapse. The trial also has a translational component aimed at establishing whether …

neutrophil count
adjuvant therapy
xelox regimen
  • 04 Mar, 2022
  • 1 location
Efficacy of Mirabegron Versus Tamsulosin Versus Solifenacin for Treatment of Ureteral Stents-Related Symptoms

The primary objective of this prospective, single-centre randomized controlled trial is to assess the efficacy of three different drugs in treatment of ureteral stents related symptoms (Beta 3 adrenergic receptor agonist; Mirabegron 50mg) vs. (Alpha 1 adrenergic receptor antagonist; Tamsulosin 0.4mg) vs. (Anticholinergic; Solifenacin 10 mg) using validated symptoms questionnaires. …

  • 30 Nov, 2021
  • 1 location
Intervention Through EMDR and CBT With Women Victim of Childhood Sexual Abuse. A Randomized Controlled Trial.

This study evaluates the effectiveness of two types of therapy for the treatment of sexual abuse psychological impact on a sample of Spanish women. The participants will receive first Trauma-Focused Cognitive Behavioral Therapy and Eye Movement Desensitization and Reprocessing treatments in order to observe the impact on symptoms of Posttraumatic …

sexual abuse
behavior therapy
  • 31 Jul, 2021
  • 1 location
Sildenafil for Treatment of Urinary Incontinence in Patients With Spinal Cord Injuries

The goal of this study is to determine whether administration of sildenafil will decrease urine leakage in patients with spinal cord injuries.

urodynamic studies
spinal cord disorder
spinal cord
leakage of urine
  • 25 Mar, 2022
  • 1 location
Effect of EMG Biofeedback in Female Patients With Stress Urinary Incontinence (1)

The aim of this randomized controlled study was to compare the EMG biofeedback method with pelvic floor muscle (PTC) exercises and Sham EMG biofeedback group in women with stress urinary incontinence (SUI) on pelvic floor muscle strength, trunk endurance, subjective perception of improvement, severity of complaints, pad test and quality …

  • 17 May, 2022
Hydroxychloroquine to Increase Tumor Suppressor PAR-4 Levels in Oligometastatic Prostate Cancer

Treatment of recurrent oligometastatic prostate cancer may be enhanced by the addition of Hydroxychloroquine to the current treatment regimens. Potential benefits of Hydroxychloroquine include delayed disease progression and delayed initiation of androgen deprivation therapy (ADT), thus lessening morbidity, distressing side effects, and improving functioning and quality of life in men …

antiandrogen therapy
androgen suppression
  • 27 Feb, 2022
  • 1 location
Transcranial Weak Current Stimulation Treatments for Working Memory Dysfunction in Schizophrenia

For the present study, Investigators will examine the efficacy of active prefrontal anodal tDCS versus placebo (sham) interventions to treat WM dysfunction in schizophrenia. Investigators selected the prefrontal stimulation modality that proved most effective in enhancing high-load WM performance in single dose stimulation in healthy participants . The study employs …

schizoaffective disorder
  • 14 Apr, 2022
  • 1 location
Intraoperative Neuromonitoring of Pelvic Autonomous Nerve Plexus During Total Mesorectal Excision

The purpose of this research protocol is the evaluation of the improvement of the anorectal and urogenital urinary function, alongside the postoperative quality of life after the application of pIONM in patients submitted to TME for rectal cancer.

total mesorectal excision
  • 29 Sep, 2021
  • 1 location