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Found 49 clinical trials
Exploring the Modulatory Role of Sex Hormones Along the Neuromechanical Axis in Females (EMRSHN)

The goal of this project is to test our central hypothesis that changes in sex hormone concentration result in changes to the basic elements of motor control - at multiple levels, from the musculotendinous unit to motor control circuitry. Under Aim 1 the investigator will determine the influence of sex …

Accepts healthy volunteers
  • 25 Mar, 2022
  • 1 location
Effect of Interval Aerobic Training on Hormonal Metabolic and Tumor Markers in Postmenopausal

PURPOSE to determine the effect of interval training on sex hormones, metabolic and tumor markers BACKGROUND Cancer is one of

  • 30 Sep, 2021
  • 1 location
Influences of Female Sex and Reproductive Hormones on Physiological Aspects of Heat Acclimation

% grade) in the heat (40°C /40% relative humidity) up to 3hr per day. Changes in core temperature, heart rate, and sex hormones will be assessed to examine differences in thermoregulatory response to heat

Accepts healthy volunteers
  • 14 Apr, 2022
  • 1 location
An Oral GnRH Antagonist to Treat Mild Autonomous Cortisol Excess (MACE) Due to Adrenal Adenomas in Postmenopausal Women

endometriosis by decreasing the body's production of sex hormones. Growth of adrenal adenomas is thought to be driven by such sex hormones. Therefore, by decreasing production of these hormones, the study team

  • 16 Sep, 2021
  • 1 location
Effect of Gender Affirming Hormone Therapy on Glucose Metabolism

The study will test: whether estrogen treatment in transwomen is associated with improved insulin sensitivity and beta cell function whether testosterone treatment in transmen is associated with worsening insulin sensitivity and beta cell function whether estrogen therapy leads to enhanced immune response in older transwormen

Accepts healthy volunteers
  • 23 Mar, 2022
  • 1 location
Sirtuin-1 and Advanced Glycation End-products in Postmenopausal Women With Coronary Disease

Higher consumption of fruits and vegetables promote greater availability of phenolic compounds and these compounds were associated with vascular health. Quercetin, a phenolic compound, is the most abundant natural antioxidant belonging to the group of flavonoids. Quercetin improved lipoprotein metabolism, had antioxidant capacity, produced vasodilating substances in the vascular endothelium …

  • 23 Jan, 2021
Low-Dose Danazol for the Treatment of Telomere Related Diseases

Background DNA is a structure in the body. It contains data about how the body develops and works. Telomeres are found on the end of chromosomes in DNA. Some people with short telomeres or other gene changes can develop diseases of the bone marrow, lung, and liver. Researchers want to …

  • 18 May, 2022
  • 1 location
Human Cerebral Blood Flow Regulation (Gas Challenge)

This study tests basic differences in how men and women control brain (cerebral) blood flow (CBF), at rest and under stress. The stress is low oxygen or high carbon dioxide. The investigators hypothesize that sex differences per se, plus sex hormone differences, drive different signals in blood vessels that change …

Accepts healthy volunteers
  • 23 Apr, 2022
  • 1 location
TranspulmonarY Estrogen Gradient and Estrogen Receptors (TYEGER) in PAH (TYEGER)

Pulmonary arterial hypertension (PAH) is a disease characterized by elevated pressures in the blood vessels of the lungs that is not caused by another disease processes. More specifically, it is defined by a mean pulmonary artery pressure > 25 mm Hg, a pulmonary vascular resistance > 3 Wood Units (WU), …

right heart catheterization
vascular disease
left ventricular end-diastolic pressure
  • 23 Mar, 2022
  • 1 location
Testing the Addition of the Drug Apalutamide to the Usual Hormone Therapy and Radiation Therapy After Surgery for Prostate Cancer (INNOVATE)

energy x-ray to kill tumor cells and shrink tumors. Androgens, or male sex hormones, can cause the growth of prostate cancer cells. Drugs, such as apalutamide, may help stop or reduce the growth of

luteinizing hormone-releasing hormone agonist
hormone therapy
tumor cells
  • 20 Apr, 2022
  • 141 locations