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Found 66 clinical trials
Morphine or Fentanyl for Refractory Dyspnea in COPD (MoreFoRCOPD)

Rationale: The most important complaint in severe COPD is dyspnea which is associated with a diminished exercise tolerance, reduced quality of life and can lead to anxiety and depression. If

  • 19 Feb, 2022
  • 10 locations
Eccentric Training in Individuals With COPD

of patients with moderate-severe COPD. Previous studies have also shown that eccentric exercise, even at low load, produces results equivalent if not superior to traditional training with respect to

  • 27 Apr, 2022
  • 1 location
Nurse Coach-Led Early Palliative Care for Older Adults With COPD and Their Care Partners: The Project EPIC Pilot RCT

-implementation pilot randomized controlled trial in dyads of community-dwelling older adults with moderate to very severe COPD and their care partners randomized to usual COPD care (control) versus usual COPD

  • 17 Jun, 2022
  • 1 location
The Effectiveness Pulmonary Telerehabilitation and Cognitive Telerehabilitation in COPD Patients

The aim of our study is to compare the effectiveness of the supervized pulmonary telerehabilitation program and the cognitive telerehabilitation method, which includes pulmonary telerehabilitation methods, in patients with severe stage COPD who have difficulty exercising heavily. The effects of pulmonary and cognitive rehabilitation on dyspnea, muscle strength, functional capacity, …

pulmonary rehabilitation
  • 22 Mar, 2022
  • 1 location
Neurocognitive and Health Impact of Sleep Apnea in Elderly Veterans With Comorbid COPD

Cognitive dysfunction in the aging Veteran population is a growing health concern in the Veterans Health System. It is not known whether OSA coexisting with COPD will enhance the risk for cognitive dysfunction. The investigators sought to investigate whether these two highly prevalent diseases, that often co-exist as the 'Overlap …

apnea-hypopnea index
sleep disorder
  • 11 Mar, 2022
  • 1 location
The Impact of a Home-based Pulmonary Telerehabilitation Program in Acute Exacerbations of COPD

COPD impacts a significant proportion of the Veteran population. Acute exacerbations, or flare-ups, of COPD are associated with impaired muscle function and worse quality of life. Pulmonary rehabilitation, a formal exercise program for patients with lung disease that includes both endurance and strength training exercises, has been shown to improve …

  • 23 Jul, 2021
  • 1 location
Therapeutic Effect of PBF-680 in Patients With COPD (Respire)

The purpose of the study is to investigate the effect of PBF-680 on the chronic inflammation and the lung function of patients with COPD on top of the standard medication. The effects of PBF-680 administration will also be examined with regards to symptom improvement and safety measures.One oral dose of …

  • 17 Mar, 2022
  • 5 locations
Acute Exacerbations Treated With BenRAlizumab (The ABRA Study)

Exacerbations of asthma and COPD are an important cause of hospital admission and the main cause of annual winter bed shortages. Despite current guideline treatment with prednisolone, 40% of patients require further treatment, 15% are readmitted and, of those hospitalised, 10% die within 3 months, all by definition treatment failures. …

  • 20 May, 2021
  • 1 location
The Effect of Inhaled Nitric Oxide on Dyspnea and Exercise Tolerance in COPD (iNO)

Chronic Obstructive Pulmonary Disease (COPD) is a lung disorder commonly caused by smoking, which makes breathing more difficult. When COPD patients exercise, they are not efficient breathers and this leads to serious breathing difficulties, which often causes these patients to stop exercise at low intensities. Even though patients with a …

pulmonary disease
Accepts healthy volunteers
  • 18 Apr, 2022
  • 1 location
Different Modalities of Exercise Training in COPD With Chronic Respiratory Failure (CRF)

Advanced Chronic Obstructive Pulmonary Disease (COPD) is a condition with a negative prognosis that causes symptoms such as wheezing and fatigue that dramatically reduce the quality of life of the person with the disease. Typically, the advanced stage of COPD is characterized by a fluctuating pattern and recurrent hospitalizations, and …

respiratory failure
heart failure
endurance training
  • 21 Feb, 2022
  • 1 location