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Found 53 clinical trials
Cognitive Rehabilitation of Working Memory After Moderate to Severe Traumatic Brain Injury (REHAB-MDT)

The study aims to demonstrate improvement of daily life functioning and improvement of cognitive tests in post traumatic brain injury (TBI) patients suffering from working memory deficit, by a 3-month specific cognitive rehabilitation program, in comparison with patients with usual non-specific rehabilitation of same duration. As secondary objectives, the study …

  • 15 May, 2022
  • 1 location
Caregiver Wellness After Traumatic Brain Injury (CG-WELL): An Intervention Designed to Promote Well-being in Caregivers of Acute Moderate to Severe Traumatic Brain Injuries (CG-Well)

After injury, survivors of msTBI depend on informal family caregivers. Upwards of 77% of family caregivers experience poor outcomes, such as adverse life changes, poor health related quality of life, and increased depressive symptoms. Caregivers frequently report minimal support or training to prepare them for their new role. Periods of …

traumatic brain injury
Accepts healthy volunteers
  • 03 May, 2022
  • 1 location
Low-Intensity Focused Ultrasound on Individuals With Disorder of Consciousness of Traumatic Brain Injury

Low-intensity focused ultrasound can be effective in severe TBI patients with disorder of consciousness. This study is a prospective single arm, open-label and explorative clinical trial to

  • 22 Oct, 2021
  • 1 location
Imaging of Neuro-Inflammation and the Risk for Post-Traumatic Epilepsy

This study plans to evaluate the time course of inflammation in the brain after a moderate to severe traumatic brain injury using positron emission tomography (PET) brain imaging. Patients will

  • 24 Jul, 2022
  • 1 location
International Trial of Efficacy of Cytoflavin in Head Trauma

The study will access the efficacy and safety of treatment with CITOFLAVIN in patients with non-penetrating moderately severe traumatic brain injury (TBI). The study recruits patients 18-60

  • 28 Aug, 2021
  • 2 locations
Brain Oxygen Optimization in Severe TBI, Phase 3 (BOOST3)

BOOST3 is a randomized clinical trial to determine the comparative effectiveness of two strategies for monitoring and treating patients with traumatic brain injury (TBI) in the intensive care unit (ICU). The study will determine the safety and efficacy of a strategy guided by treatment goals based on both intracranial pressure …

traumatic brain injury
ct scan
  • 22 Mar, 2022
  • 35 locations
PROphylaxis for Venous ThromboEmbolism in Severe Traumatic Brain Injury (PROTEST) (PROTEST)

This is a pilot study, phase III, multi-centre, double blind, randomized controlled trial of patients with traumatic brain injury (TBI).

traumatic brain injury
severe traumatic brain injury
subarachnoid hemorrhage
  • 16 Feb, 2022
  • 10 locations
Beta Blocker Use In Traumatic Brain Injury Based On The High-Sensitive Troponin T Status

early administration of propranolol based on the HSTnT status will improve the outcome of mild-to-severe TBI patients. Our primary hypothesis is that BBs are effective in reducing 10 and 30-day

  • 05 Mar, 2021
  • 1 location
HEMOglobin Transfusion Threshold in Traumatic Brain Injury OptimizatioN: The HEMOTION Trial

severe TBI are left with major functional impairment. Current management guidelines are based on limited evidence and practice is highly variable. Most acutely ill patients with TBI will develop anemia

traumatic brain injury
  • 25 Jan, 2021
  • 24 locations
Pediatric Guideline Adherence and Outcomes- Argentina

Pediatric traumatic brain injury (TBI) is the leading killer of children worldwide but effective treatments for TBI are limited. Although evidenced-based pediatric TBI guidelines exist, adherence to these guidelines is low,leading us to develop a new Pediatric Guideline Adherence and Outcomes (PEGASUS) program to increase TBI guideline adherence. We propose …

head ct
traumatic brain injury
  • 19 Feb, 2022
  • 16 locations