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Found 62 clinical trials
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Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

Background: Severe aplastic anemia (SAA) and myelodysplastic syndrome (MDS) are bone marrow diseases. People with these diseases usually need a bone marrow transplant. Researchers are testing ways to make stem cell transplant safer and more effective. Objective: To test if treating people with SAA or MDS with a co-infusion of …

myelodysplastic syndrome (mds)
anemia studies
aplastic anemia
myelodysplastic syndromes
  • 57 views
  • 22 Dec, 2020
  • 1 location
Lentiviral Gene Therapy for X-linked Severe Combined Immunodeficiency

Severe combined immunodeficiency disorder (SCID) is a heterogeneous group of inherited disorders characterized by a profound reduction or absence of T lymphocyte function, resulting in lack of

  • 3 views
  • 03 Feb, 2022
  • 1 location
Minocycline as Adjunctive Treatment for Treatment Resistant Depression (MINDEP2)

respond to antidepressant treatment, confirmed by the Structured Clinical Interview for DSM-5 (SCID-5) and the Antidepressant Treatment History Form (ATHF) at screening. After screening and randomization

sertraline
antidepressants
duloxetine
bupropion
depressive symptoms
  • 110 views
  • 07 Oct, 2022
  • 1 location
Reducing Neural Perseveration Through Closed Loop Real Time fMRI Neurofeedback to Alleviate Depressive Symptoms

This study tests the efficacy of a new psychotherapeutic strategy for reducing negative attention bias (and therefore depression severity) in participants with MDD (60 in R61 phase and 80 in R33 Phase). This real-time fMRI neurofeedback therapy uses cloud-based pattern classification to decode a patient's attentional state and dynamically modulate …

  • 6 views
  • 24 Oct, 2022
  • 1 location
bBeAMom: Effectiveness of a Cognitive-Behavioral Blended Intervention for Postpartum Depression (bBeAMom)

Be a mom program (a web-based cognitive-behavioral intervention) is being tested in another clinical trial as a preventive intervention for postpartum depression (NCT03024645). However, given its effectiveness in reducing depressive symptoms among women presenting early-onset postpartum depressive symptoms, Be a Mom can also have potential as a postpartum depression complement …

anxiety
depressive symptoms
depressive episode
depressed mood
behavior therapy
  • 0 views
  • 04 Oct, 2022
  • 1 location
Prevention of OUD: The HOME (Housing, Opportunities, Motivation and Engagement) Randomized Trial (HOME)

Homeless youth have a much higher rate of substance use than non-homeless peers with evidence suggesting that homeless youth have the highest rates of opioid use among youth subgroups in the country (Brands et al., 2005); heroin using homeless youth also appear to have the highest rates of IV drug …

Accepts healthy volunteers
  • 8 views
  • 23 Oct, 2022
  • 1 location
Plan D- Vitamin D Supplementation in Psychotic Disorders

Background: Impairment in cognitive processing speed is a consistent finding in schizophrenia spectrum disorder. Vitamin D deficiency is found to be significantly associated with reduced processing speed. In this study, we will investigate the effect from vitamin D supplementation on processing speed. Objective: The primary objective is to investigate whether …

  • 0 views
  • 26 Apr, 2022
  • 1 location
Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

The goal of this proposal is to test the overall hypothesis that e-cigarettes (ECs) provide efficient nicotine delivery to the brain and arterial blood in non-EC-naïve smokers and e-cigarette users and that EC liquid characteristics modulate this effect. This study will test the hypothesis through complementary methods that include [ …

  • 84 views
  • 23 Mar, 2022
  • 1 location
Follow-up Study With Clinical Vitamin D Supplementation Trial on Patients With Depression (DepFuD)

information. All participants give blood samples for biomarker analyses at time points 3, 6, 18 months and 5 years. Clinical interviews of mental disorders (e.g. SCID) and anthropometric measurements (e.g

antidepressants
recurrent depression
depressed mood
psychosis
scid
  • 4 views
  • 23 Jan, 2021
  • 1 location
Study to Compare the Use of a Behavioral Health App Versus Care as Usual for 16-22 Year Olds With Depression

Randomized Controlled Trial comparing a coach-enhanced digital cognitive behavioral intervention (d-CBI) (RxWell) + treatment as usual (TAU) versus TAU alone for moderate depression as determined by Patient Health Questionnaire (PHQ-9) threshold as part of routine pediatric care. The study will be completed in pediatric practices with embedded behavioral therapists across …

depressed mood
behavior therapy
anxiety
  • 0 views
  • 04 Oct, 2022
  • 1 location