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Found 8 clinical trials
The Effects of Dietary Supplementation on Serum Protein Glycosylation

Two randomized double-blind placebo-controlled clinical studies to assess the effects of dietary glycan monomer supplementation on the immune system, especially antibody glycosylation in healthy adults. Immune profiling and glycoproteomics will be performed on serum isolated at these same time points.

Accepts healthy volunteers
  • 0 views
  • 11 May, 2022
  • 1 location
Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM

This phase I trial studies the side effects of stereotactic radiosurgery with MBG453 and spartalizumab in treating patients with recurrent glioblastoma multiforme (GBM). Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor to more precisely target the cancer. Monoclonal antibodies, …

temozolomide
contrast-enhanced magnetic resonance imaging
tumor cells
MRI
karnofsky performance status
  • 6 views
  • 09 Aug, 2022
  • 2 locations
Response Assessment in SB CD

serum proteins whose differential expression pattern from Week 0 to week 6 after starting a biologic can predict week 14 clinical remission in SBCD patients. The significance of this proposal is that

  • 13 views
  • 21 Mar, 2022
  • 1 location
Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention (PROSe-ICD)

The overall hypothesis of this study is that subtle interactions between structural (substrate) and functional (trigger) abnormalities of the heart, some of which are genetically-determined, can be used to identify patients at high risk of sudden cardiac death (SCD). Such information may be used to better define patients most likely …

primary prevention
myocardial infarction
sudden cardiac death
cardiac death
  • 60 views
  • 13 Mar, 2022
  • 4 locations
Serum-Protein-Based Indices for the Progression of Fracture Healing and Nonunion (UNION)

To define a serum protein-based diagnostic for the progression and failure of fracture healing, through the identification of a set of serum proteins that appear at early times of biological

  • 0 views
  • 10 Aug, 2022
  • 1 location
A Multicenter Prospective Observational Study on Predictive Models and Clinical Outcome of Radiation Pneumonitis

radiotherapy. The purpose of this study is to: Identify biomarkers including serum proteins, gene expression, genetic changes, and epigenetic modifications that determine radiation

  • 0 views
  • 25 Jul, 2022
  • 1 location
Developing a Test for the Detection of Ovarian Cancer

The study aims to develop a test for early detection of ovarian cancer using DNA from a growth involving the ovary found in a washing of the uterus (womb), and proteins found in the blood. The samples of the wash and the blood will be taken before surgery. After surgery, …

cavity
BRCA2
fallopian tube
ovarian cancer
cancer of the ovary
  • 0 views
  • 10 May, 2022
  • 4 locations
Study of Plasma Tumor-promoting Factors and Immune Function After Laparotomy Cytoreductive Surgery and HIPEC vs. PIPAC in Patients With Peritoneal Metastasis

The general goal of this study is to investigate the effect of treatment on serum concentrations of proteins known to impact angiogenesis or tumor growth and establishment in patients with peritoneal metastasis of various origin. Since the immune system is thought, by many, to have an impact on tumor growth …

  • 0 views
  • 23 Jan, 2021
  • 1 location