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Found 10 clinical trials
Open-Label Efficacy and Safety Study of Pozelimab in Patients With CD55-Deficient Protein-Losing Enteropathy (CHAPLE Disease)

active disease at baseline and those with inactive disease on eculizumab, switching to pozelimab) at time points until 104 weeks To determine the effects of pozelimab on albumin and other serum

  • 12 Aug, 2021
  • 3 locations
Trial of Anti-Tim-3 in Combination With Anti-PD-1 and SRS in Recurrent GBM

This phase I trial studies the side effects of stereotactic radiosurgery with MBG453 and spartalizumab in treating patients with recurrent glioblastoma multiforme (GBM). Stereotactic radiosurgery is a specialized radiation therapy that delivers a single, high dose of radiation directly to the tumor to more precisely target the cancer. Monoclonal antibodies, …

recurrent glioblastoma
neutrophil count
gliadel wafer
karnofsky performance status
  • 15 Apr, 2021
  • 1 location
Identification of Protective and Worsening Steatohepatitis (NASH) Factors

The main aim of this work will be to identify a profile of gene expression by microarray in the liver which might allow to differentiate obese subjects having a normal liver from those with steatohepatitis or steatosis.

obesity surgery
body mass index
fatty liver
liver disease
  • 07 Nov, 2020
  • 1 location
Response Assessment in SB CD

serum proteins whose differential expression pattern from Week 0 to week 6 after starting a biologic can predict week 14 clinical remission in SBCD patients. The significance of this proposal is that

  • 25 Jan, 2021
  • 1 location
Detection of Early Lung Cancer by Serum Protein Expression Profiling

Promising new technology exists to examine small proteins that are shed by cancers into the blood stream. The purpose of this study is to see if there are differences in the proteins and protein levels in blood from individuals with early stage lung cancer compared to healthy adults.

  • 07 Nov, 2020
  • 1 location
Novel Serum Markers for Monitoring Response to Anti-Cancer Therapy

The purpose of this study is to measure the levels of serum proteins and other biomarkers in cancer patients and in patients suspected of having cancer. We believe that some of these markers may

karnofsky performance status
cancer treatment
primary cancer
  • 16 May, 2021
  • 1 location
Prospective Observational Study of the ICD in Sudden Cardiac Death Prevention

The overall hypothesis of this study is that subtle interactions between structural (substrate) and functional (trigger) abnormalities of the heart, some of which are genetically-determined, can be used to identify patients at high risk of sudden cardiac death (SCD). Such information may be used to better define patients most likely …

sudden cardiac death
myocardial infarction
primary prevention
cardiac death
  • 30 Jan, 2021
  • 4 locations
Development of a Serum Test for Colorectal Cancer Screening (COLODIAG pr clinique)

shown its interest in terms of screening for adenomas and colorectal cancers. The assay of 7 serum proteins (which will be the subject of a patent application in 2020), by ELISA test, is the subject of

  • 05 Jul, 2021
  • 1 location
Developing a Test for the Detection of Ovarian Cancer

The study aims to develop a test for early detection of ovarian cancer using DNA from a growth involving the ovary found in a washing of the uterus (womb), and proteins found in the blood. The samples of the wash and the blood will be taken before surgery. After surgery, …

  • 24 Mar, 2021
  • 6 locations
Study of Plasma Tumor-promoting Factors and Immune Function After Laparotomy Cytoreductive Surgery and HIPEC vs. PIPAC in Patients With Peritoneal Metastasis

The general goal of this study is to investigate the effect of treatment on serum concentrations of proteins known to impact angiogenesis or tumor growth and establishment in patients with peritoneal metastasis of various origin. Since the immune system is thought, by many, to have an impact on tumor growth …

  • 23 Jan, 2021
  • 1 location