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Found 32 clinical trials
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Specifying and Treating Anxiety in Autism Research

The Specifying and Treating the Anxiety Phenotype in Autism Spectrum Disorder (STAAR) study aims to better characterize the sub-group of children and preadolescents with ASD that exhibit clinically significant anxiety by conducting a 16-week randomized comparative treatment trial of the Behavioral Intervention for Anxiety in Children with Autism (BIACA), the …

autism
cognitive behavior therapy
speech therapy
selective serotonin reuptake inhibitor
sertraline
  • 91 views
  • 29 Jan, 2021
  • 1 location
None
Dienogest Versus Luteal Phase Fluoxetine in the Management of Premenstrual Syndrome

Two hundreds and ten women with premenstrual syndrome will be randomly divided into 3 equal groups using computer generated random numbers. Group 1 will receive oral dienogest (visanne Bayer, Germany) 2mg for 14 days starting from the 15th day of menstruation, Group 2 will receive fluoxetine (Prozac Lilly, UK) 20mg …

fluoxetine
dienogest
  • 7 views
  • 27 Jan, 2021
  • 1 location
None
Predicting SSRI Efficacy in Veterans With PTSD

This is a research study to examine the effectiveness of a brief screening method that may predict which people with posttraumatic stress disorder (PTSD) are most likely to show a positive response to selective serotonin reuptake inhibitor (SSRI) medications. Participants will be recruited over approximately 3.25 years, until at least …

sertraline
selective serotonin reuptake inhibitors
  • 2 views
  • 06 Nov, 2021
  • 1 location
None
A Neurosteroid Intervention for Menopausal and Perimenopausal Depression

HYPOTHESIS Pregnenolone administration will be associated with greater reduction in depressive symptom severity than placebo in women with current mMDD. STUDY AIMS: Primary Aim: Determine if pregnenolone is associated with greater reduction in depressive symptom severity than placebo in women with mMDD, as measured by MADRS. Secondary Aims: Determine if …

mmdd
major depressive disorder
anxiety
depressive symptoms
hot flashes
  • 454 views
  • 02 Sep, 2021
  • 1 location
None
5-HTP and Creatine for Depression

This is a three-armed clinical trial examining the effect of 5-hydroxytryptophan and creatine monohydrate as augmenting agents for the treatment of depression. Subjects will be randomized between 5-HTP + placebo, creatine + placebo, and 5-HTP + creatine, for 8 weeks. The ability of the interventions to affect biomarkers associated with …

  • 15 views
  • 11 May, 2021
  • 1 location
None
Pragmatic Collaborative Care for Cardiac Inpatients With Depression or Anxiety

The investigators will complete a pragmatic randomized trial (N=260) of the 26-week blended collaborative care (CC) intervention compared to enhanced usual care (eUC) in patients admitted for acute coronary syndrome (ACS) or heart failure (HF) found to have current depression, generalized anxiety disorder (GAD), or panic disorder (PD). The CC …

unstable angina
cardiac event
myocardial infarction
angina pectoris
heart failure
  • 100 views
  • 24 Jan, 2021
  • 1 location
None
Microvascular Dysfunction in Obesity

Impaired endothelial function is observed in disease states related to obesity, such as atherosclerosis, coronary artery disease, and diabetes. Reactive oxygen species (ROS) production and resultant oxidative stress contribute to the development of these obesity-related diseases. The enzyme NADPH-oxidase is a major source of oxidative stress within the vasculature, and …

diabetes
metabolic syndrome
  • 0 views
  • 13 Aug, 2021
  • 1 location
None
Clinical Effectiveness of TARA Compared to Standard Treatment for Adolescents and Young Adults With Depression

Depressive Disorders constitute an increasing global health concern and available treatments for young people have not been sufficiently effective in haltering this trend. The novel group treatment program "Training for Awareness, Resilience, and Action" (TARA) was developed to target specific mechanisms based on neuroscientific findings in adolescent depression. TARA is …

  • 0 views
  • 08 Apr, 2021
  • 6 locations
None
Effects of Menopause Hormonal Therapy and Selective Serotonin Reuptake Inhibitor on Cognition Sexual Function and Quality of Life

Cross-sectional study with postmenopausal women using hormone therapy or serotonin reuptake inhibitor to relieve climacteric symptoms or without any treatment. Participants will answer three questionnaires: FSFI (the Female Sexual Function Index), MENQOL (Menopause-specific Quality of Life) and MEEM (Mini-Mental State Examination). The results will be compared according to treatment group.

progestin
estrogen
replacement therapy
hormone therapy
  • 0 views
  • 01 Oct, 2021
  • 1 location
None
Identification/Characterization of Changes in Microscopic Colitis

The goal of this study is to establish a prospective observational cohort of adult patients with microscopic colitis and collect clinical information and specimens over the course of their treatment. This information will be used in order to establish a patient registry with detailed clinical data and a specimen repository …

  • 0 views
  • 12 Sep, 2021