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Found 31 clinical trials
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Hypoglycemia Associated Autonomic Failure in Type 1 Diabetes Mellitus (DM)

reuptake inhibitors (SSRI's) such as Prozac has been demonstrated to increase basal epinephrine levels and enhance baroreflex control of Sympathetic nervous system (SNS) activity. What is unknown is

hypoglycemia
body mass index
diabetes
glycosylated hemoglobin
insulin
  • 145 views
  • 11 Apr, 2021
  • 1 location
None
Effect of Serotonergic Stimulation on the Gut-brain Axis

Selective serotonin reuptake inhibitors increase the level of serotonin. This study will use functional magnetic resonance imaging to examine how subjects with, and without, irritable bowel

escitalopram
visceral pain
microbiota
  • 20 views
  • 07 Mar, 2021
  • 4 locations
None
Partners in Caring for Anxious Youth

comparative efficacy study remission occurred in about 65% of children and adolescents treated with a combination of a selective serotonin reuptake inhibitors (SSRI) and cognitive behavioral therapy (CBT). In

  • 0 views
  • 10 Sep, 2021
  • 3 locations
None
Arbaclofen vs. Placebo in the Treatment of Children and Adolescents With ASD (ARBA)

This study will examine the safety and efficacy of arbaclofen vs. placebo on social function in children and adolescents with Autism Spectrum Disorder (ASD).

psychiatric disorder
arbaclofen
autism
pervasive developmental disorder
  • 90 views
  • 20 Aug, 2021
  • 4 locations
None
Citalopram as a Posterior Cortical Protective Therapy in Parkinson Disease

This Parkinson disease (PD) trial will test whether 26 months of citalopram, compared to placebo, can alter the build-up of toxic amyloid-beta plaques in the visuospatial cortex of the brain linked to visuospatial cognitive impairment in PD.

cognitive impairment
dopamine
  • 0 views
  • 14 Jul, 2021
  • 1 location
None
The Role of Serotonin in Compulsive Behavior in Humans: Underlying Brain Mechanisms

The aim of this project is to investigate: The status of the central serotonin (5-hydroxytryptamine, 5-HT) system in compulsive behaviour and how it is affected by sub-chronic escitalopram administration The mechanisms underlying how sub-chronic administration of escitalopram affects the central 5-HT system How changes in cognitive performance, including the balance …

citalopram
MRI
compulsive behavior
  • 0 views
  • 24 Jan, 2021
  • 1 location
None
Trial of Dronabinol Adjunctive Treatment of Agitation in Alzheimer's Disease

Alzheimer's disease (AD) is the most prevalent neurodegenerative disease of aging. Neuropsychiatric symptoms (NPS) in AD are a major cause of burden to patients, caregivers, and society and are near-universal at some point in the AD course. One of the most troubling of these symptoms is agitation (Agit-AD), typified by …

cognitive impairment
dementia
neuropsychiatric symptoms
alzheimer's disease
agitation
  • 47 views
  • 14 Aug, 2021
  • 3 locations
None
Noninvasive Modulation of Motivational Brain Regions in Healthy Volunteers

42 healthy control participants will be recruited. On Day 1 they will complete reward-guided decision making tasks and questionnaires followed by a functional magnetic resonance imaging (fMRI) scan. On Day 2 they will receive repetitive transcranial magnetic stimulation (rTMS) targeting a specific part of the brain called the dorsal anterior …

traumatic brain injury
Accepts healthy volunteers
  • 0 views
  • 06 Oct, 2021
  • 1 location
None
Evaluation of Efficacy and Safety of add-on Sarcosine in Patients With Major Depressive Disorder

One-third of the patients with major depressive disorder do not respond to conventional antidepressants that act through the mono-aminergic system. The available treatment modalities, including SSRIs, are slow to act and have a lag time before showing improvement in symptoms of patients. To overcome these treatment hurdles, add-on therapy to …

  • 0 views
  • 06 Nov, 2021
  • 1 location
None
Specifying and Treating Anxiety in Autism Research

The Specifying and Treating the Anxiety Phenotype in Autism Spectrum Disorder (STAAR) study aims to better characterize the sub-group of children and preadolescents with ASD that exhibit clinically significant anxiety by conducting a 16-week randomized comparative treatment trial of the Behavioral Intervention for Anxiety in Children with Autism (BIACA), the …

sertraline
applied behavior analysis
autism
behavior therapy
depression
  • 91 views
  • 29 Jan, 2021
  • 1 location