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Found 154 clinical trials
Fluids in Septic Shock (FISSH) (FISSH)

resuscitation in septic shock on patient-important outcomes such as mortality and AKI.

  • 07 Jul, 2022
  • 17 locations
Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP) (PITSTOP)

Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensive, and frequently lethal condition. A growing body of evidence suggests that early recognition and treatment of sepsis can improve survival. Unfortunately, many …

  • 05 Mar, 2022
  • 1 location
Hydrocortisone and Fludrocortisone for Critical Illness-related Corticosteroid Insufficiency (HORNbILL)

The study aims at assessing the efficacy and the safety of hydrocortisone combined with fludrocortisone compared to placebo in ICU adults with critical illness related corticosteroid insufficiency.

  • 21 Mar, 2022
Blood Purification in Patients With Septic Shock

In recent years, many studies have pointed out that bacterial toxin storm and cytokine storm are the main causes of patients with septic shock and multiple organ dysfunction. Endotoxins are the

  • 04 Oct, 2022
  • 1 location
Predictive Mini-bolus Fluid Responsiveness in Pediatric Septic Shock

Severe sepsis and septic shock remain of particular gravity in children with a current mortality of about 20 % , despite the international prevention campaigns " survival sepsis campaign

  • 15 Apr, 2021
  • 1 location
Ilomedin in Septic Shock With Persistent Microperfusion Defects (I-MICRO) (I-MICRO)

Septic shock remains a major cause of death in critically ill patients. Alterations in microcirculation have long been proposed as a key pathophysiological factor of organ dysfunction and death

  • 07 Oct, 2022
  • 1 location
Recovery From Acute Immune Failure in Septic Shock by Immune Cell Extracorporeal Therapy (ReActiF-ICE)

> This may contribute to the improvement of the impaired organ function of septic shock patients by assisting the impaired immune system (immune competence enhancement = ARTICE)

blood lactate
severe sepsis
septic shock
  • 07 Oct, 2022
  • 4 locations
Sodium Bicarbonate Ringer's Solution Versus Normal Saline for Early Fluid Resuscitation in Patients With Sepsis

At present, people still have different opinions on choosing which kind of crystalloid solution for patients with sepsis, and there is no unified standard yet. It is necessary to conduct systematic studies on comparison of different fluid resuscitation methods on the efficacy and safety of crystalloid solution for patients with …

  • 27 Apr, 2022
  • 1 location
Study of Subcutaneous Interstitial Pressure During Sepsis (PISEP)

this study is to analyze subcutaneous IP (SCIP) in patients with septic shock compared with controls in order to evaluate the direct role of interstitial tissue in the onset of edema during sepsis.

  • 09 Feb, 2022
  • 2 locations
Evaluation of Oxiris Membrane as a Treatment for Ischemia-reperfusion Syndrome in Cardiogenic Shock Treated With Extracorporeal Life Support (ECMO/ECLS): A Randomized Pilot Study ECMORIX

blood. During septic shock, this membrane has shown its effectiveness and made it possible to decrease the doses of vasopressors administered, thus limiting the negative consequences of their use (low

  • 11 Jul, 2021
  • 1 location