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Found 40 clinical trials
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Proof of Mechanism Study for the Treatment of Social Anhedonia in ASD

This project will use the experimental medicine approach of a Phase IIa Proof of Mechanism 16-week, randomized, double-blind, controlled trial of L-DOPA versus placebo administration in combination with a 16 week social skills training group in order to: 1) identify differences in social reward processes in adolescent and young adult …

placebo administration
social interaction
social skills training group
  • 0 views
  • 24 Jan, 2021
None
Evaluation of the Efficacy and Safety of a Simplified Procedure for the Percutaneous Closure of the Patent Foramen Ovale

Patent Foramen Ovale, is an embryonic remnant, formed by apposition of the septum primum and septum secondum composing the interatrial septum. This foramen ovale is permeable during intra-uterine life and allows inter-auricular communication. It tends to close at birth, due to increased pressure from the left atrium. However, it remains …

atrial fibrillation
anesthesia
aneurysm
stroke
antiplatelet therapy
  • 0 views
  • 26 Jan, 2021
  • 3 locations
None
Evaluation of the Severity of Right to Left Shunt in PFO Patients After Systemic Embolism

The aim of the project is to identify new risk indicators of PFO. The evaluation of the R-L shunt is based on the newly developed precise measurement technique. Moreover, this measurement of R-L shunt is feasible in a case when R-L shunt is present only intermittently. Multicentric study with 150 …

  • 0 views
  • 26 Jan, 2021
  • 6 locations
None
Intranasal Vasopressin Treatment in Children With Autism

This purposed of this clinical trial is to investigate the effectiveness of vasopressin nasal spray for treating symptoms associated with autism. Vasopressin is a hormone that is produced naturally within the body and has been implicated in regulating social behaviors. It has been proposed that administration of the hormone may …

autism
nasal spray
psychotropic
vasopressin
psychotropic drugs
  • 768 views
  • 10 Oct, 2021
  • 1 location
None
Cannabidiol for ASD Open Trial

This is a 6-week open trial to identify the optimal dosing of cannabidiol (CBD) in youth with autism spectrum disorder (ASD) and to identify primary and secondary outcomes for future controlled studies. This study evaluates change in symptoms commonly associated with ASD, as evidence suggests that CBD may be eective …

autism
cannabidiol
adverse effect
pervasive developmental disorder
anxiety
  • 226 views
  • 05 Oct, 2021
  • 1 location
None
Examining the Effects of a Job Entry Intervention

The current study will examine the efficacy of a virtual reality (VR) intervention entitled "Virtual Reality Job Interview Training (VR-JIT)" as well as a newly developed Kessler Foundation STRength IDentification and Expression tool (VR-STRIDE) with adolescents diagnosed with autism spectrum disorder.

  • 0 views
  • 08 Apr, 2021
  • 1 location
None
Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke

To determine the safety of antithrombotic treatment discontinuation 12 months following successful transcatheter PFO closure.

  • 0 views
  • 29 Sep, 2021
  • 1 location
None
Optical Tissue Identification for Myocardial Architecture

The goal of this study is to test the hypothesis that fiberoptic confocal microscopy (FCM) imaging during repair of common congenital heart defects is a useful adjunct for avoidance of conduction abnormalities.

  • 0 views
  • 25 Jun, 2021
None
PFO Occlusion and Atrial Fibrillation

Interventional closure of patent foramen ovale (PFO) associates with reduced risk of stroke recurrence in patients with cryptogenic ischemic stroke as reported in the recent CLOSE and REDUCE trials. The long-term follow-up results of the RESPECT and DEFENSE-PFO trial confirmed these findings. PFO closure is therefore recommended in patient with …

  • 0 views
  • 01 Jun, 2021
  • 1 location
None
GORE CARDIOFORM Septal Occluder Migraine Clinical Study

Multi-center, prospective, randomized, placebo- and sham-controlled study to evaluate the GORE CARDIOFORM Septal Occluder for migraine headache relief

antidepressants
headache
  • 0 views
  • 09 Aug, 2021
  • 3 locations