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Found 561 clinical trials
Featured trial
Hospital Airway Resuscitation Trial (HART)

Cardiac arrest occurring in the hospital is a major burden to patients and their families. Unfortunately, given the emergent nature of cardiac arrest, few studies have been able to help us figure out treatments or techniques that work best. This study will help us understand if one approach to giving …

  • 0 views
  • 30 Sep, 2022
  • 1 location
Paramedic Initiated Treatment of Sepsis Targeting Out-of-hospital Patients (PITSTOP) (PITSTOP)

Sepsis occurs when a serious infection - most commonly infection of the lungs, urinary system, or blood - leads to acute organ failure. It is a common, expensive, and frequently lethal condition

  • 9 views
  • 05 Mar, 2022
  • 1 location
Fluids in Septic Shock (FISSH) (FISSH)

Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world. Given uncertainty about the impact of lower chloride versus higher chloride solutions on mortality, it is unlikely that clinical practice will change without new …

  • 22 views
  • 07 Jul, 2022
  • 17 locations
Antibioprophylaxis for Excision-graft Surgery in Burn Patient (A2B-TRIAL)

-operative local and systemic infections. Burn surgery is associated with a high risk of bacteremia and postoperative infections and sepsis. However, antibiotic prophylaxis exposes to the risk of selecting

  • 0 views
  • 26 Jan, 2021
  • 1 location
Maternal- Fetal Infection (InSPIRe)

The purpose of the protocol is to validate a novel point of care multiplex system to detect and characterize microorganisms responsible for neonatal sepsis, as well as biomarkers of infection

  • 2 views
  • 14 Feb, 2022
  • 3 locations
PROcalcitonin Impact on Antibiotic Reduction, adverSe Events and AVoidable healthcarE Costs (ProSAVE): A RCT (ProSAVE)

prescription guided by a PCT-algorithm via a Stewardship Team over standard guidelines in hospitalized adult patients with suspected or confirmed LRTI (including sepsis with respiratory focus).

community acquired pneumonia
antibiotic therapy
procalcitonin
antibiotics
  • 23 views
  • 11 Mar, 2022
  • 4 locations
Efficacy of DEXamethasone in Patients With Acute Hypoxemic REspiratory Failure Caused by INfEctions (DEXA-REFINE)

established AHRF (including ARDS) caused by confirmed pulmonary or systemic infections, admitted in a network of Spanish ICUs. Eligible patients will be randomly assigned to receive dexamethasone: either 6 mg

  • 0 views
  • 10 Apr, 2022
Gastroschisis Outcomes of Delivery (GOOD) Study

The objective of this study is to investigate the hypothesis that delivery at 35 0/7- 35 6/7 weeks in stable patients with gastroschisis is superior to observation and expectant management with a goal of delivery at 38 0/7 - 38 6/7 weeks. To test this hypothesis, we will complete a …

  • 408 views
  • 16 Sep, 2022
  • 19 locations
RCT Cefiderocol vs BAT for Treatment of Gram Negative BSI (GAMECHANGER)

The purpose of this study is to determine whether a new antibiotic, Cefiderocol which works against a wide variety of gram negative bacteria, is equally effective as the antibiotics that are currently used as current standard of care.

  • 111 views
  • 16 Jun, 2022
  • 13 locations
(CONCERN) Clinical Decision Support (CDS) System

There are patients who die or have a bad outcome in the hospital and this could be prevented. Data in the nurses' notes could be used by computers to tell the rest of the care team that a patient is not doing well and that they should act more quickly. …

  • 0 views
  • 09 Aug, 2022
  • 1 location