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Found 75 clinical trials
A 6-Month Extension Study of VMDN-003-2 to Assess Engensis in Participants With Painful Diabetic Peripheral Neuropathy (REGAiN-1B)

To evaluate the durability of efficacy and long-term safety of intramuscular (IM) administration of Engensis or Placebo that was administered in the double-blind, randomized, VMDN-003-2 Placebo-controlled Phase 3 Study.

  • 0 views
  • 04 Oct, 2022
  • 13 locations
Dissecting the Heterogeneity of Oral Cancer Pain

Oral squamous cell carcinoma (SCC) produces a higher prevalence and more severe pain than all other cancers. Orofacial pain is one of the most common initial symptoms of oral cancer and often leads to the diagnosis of oral cancer. However, the character, severity, and unique features of oral cancer widely …

Accepts healthy volunteers
  • 0 views
  • 17 Oct, 2022
  • 1 location
The Effects of Immobilisation and Exercise on Homeostatic Plasticity Mechanisms in Healthy Participants

Homeostasis is important for maintaining a stable equilibrium of e.g., blood pressure, hormonal release, and release of neurotransmitters. Within the healthy brain, homeostatic plasticity mechanisms ensure stability in synaptic plasticity that maintains cortical excitability within a normal physiological range, while this regulation has been shown to be impaired in chronic …

Accepts healthy volunteers
  • 0 views
  • 04 Oct, 2022
  • 1 location
Dural Puncture Epidural Versus Epidural Anesthesia for Cesarean Delivery

This study will compare two anesthetics techniques called Dural Puncture Epidural (DPE) and Standard Epidural as to which of the two can provide faster and potentially better at providing pain relief for cesarean sections. It will also compare these two anesthetics techniques on the percentage of women who require additional …

  • 57 views
  • 07 Oct, 2022
  • 1 location
Efficacy of Dapagliflozin in Diabetes Associated Peripheral Neuropathy (DINE)

Diabetic peripheral neuropathy(DPN) is a length dependent axonal neuropathy that affects at least 50% of patients with diabetes mellitus. DPN is often asymptomatic during the early stages of diabetes ,however, once symptoms and overt deficits have developed, it cannot be reversed. Early diagnosis of neuropathy is important because early diagnosis …

  • 0 views
  • 15 Jun, 2022
  • 1 location
Conditioning Electrical Stimulation to Improve Outcomes in Carpal Tunnel Syndrome

Carpal tunnel syndrome is common, identified in 3% of the general population. Symptoms including numbness and pain are due to compression of the median nerve as it travels through a tunnel entering the wrist and can result in weakened grip strength and poor dexterity. Despite surgical release, nerve damage due …

nerve conduction
conservative management
nerve conduction study
numbness
carpal tunnel release
  • 173 views
  • 04 Oct, 2022
  • 1 location
Thoracic Neuromodulation for Diabetic Gastroparesis (TNM-DGp)

The global incidence of diabetes is rising. Gastroparesis is a significant complication of diabetes that results in debilitating symptoms and affects quality of life. Current treatment options for diabetic gastroparesis are limited. Significant visceral afferent neuropathy is associated with diabetic gastroparesis and sympathetic overactivity is seen in nausea, both type …

  • 0 views
  • 04 Oct, 2022
  • 1 location
QST Study: Predicting Treatment Response in Chronic Pancreatitis Using Quantitative Sensory Testing

Quantitative Sensory Testing (QST) is a novel investigative technique used in other pain conditions to evaluate patterns of chronic pain, and in this study will be used to elucidate pain

ct scan
mrcp
conjugated bilirubin
Accepts healthy volunteers
chronic pancreatitis
  • 180 views
  • 07 Oct, 2022
  • 3 locations
Quantitative Sensory Testing in Chronic Pain Patients Undergoing Opioid Treatment and Opioid Tapering

, normal volunteers, and patients undergoing an opioid taper. This will be the first study to perform sensory testing on patients while undergoing an opioid taper on an outpatient basis.

Accepts healthy volunteers
  • 109 views
  • 30 Jan, 2022
  • 1 location
Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis (P-QST)

proposed clinical trial will evaluate the predictive capability of Pancreatic Quantitative Sensory Testing (P-QST) - a novel assessment of neurosensory phenotyping- for improvement in pain in patients with

chronic pancreatitis
  • 0 views
  • 23 Mar, 2022
  • 1 location