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Found 13 clinical trials
  • 1 views
  • 21 Jan, 2021
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors

This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. Drugs used in chemotherapy, such as paclitaxel, ifosfamide, …

testicular
tumor cells
cancer chemotherapy
seminoma
progressive disease
  • 803 views
  • 13 Jun, 2021
  • 94 locations
Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle

. PURPOSE: This randomized phase III trial is comparing four different MRI and CT scan schedules in patients with stage I seminoma of the testicle.

cancer
seminoma
ct scan
  • 717 views
  • 07 Nov, 2020
  • 12 locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) Epithelial tumors of penis - squamous adenocarcinoma

metastatic disease
adenoid cystic carcinoma
androgen
amylase
somatostatin
  • 5957 views
  • 13 Jun, 2021
  • 813 locations
Active Surveillance Bleomycin Carboplatin Etoposide or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as …

tumor cells
testicular
cancer chemotherapy
primary tumor
seminoma
  • 341 views
  • 03 Jun, 2021
  • 369 locations
Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma

The trial investigates a stage-adapted (stage IIA or IIB) de-escalation of the standard treatments in the context of a multimodality treatment with chemo- and radiotherapy in seminoma patients

renal function tests
cisplatin etoposide
seminoma
neutrophil count
carboplatin
  • 14 views
  • 04 Mar, 2021
  • 17 locations
Evaluating Immune Therapy Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors

The purpose of this study is to test the safety and effectiveness of durvalumab with tremelimumab in patients with relapsed or refractory germ cell tumors.

cancer chemotherapy
seminoma
measurable disease
alpha fetoprotein
beta-human chorionic gonadotropin
  • 26 views
  • 26 Jan, 2021
  • 7 locations
A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

The purpose of the CTO-IUSCCC-0752 study is to investigate the use of Cabozantinib for patients with incurable, refractory germ cell tumors. Patients will be treated until evidence of disease progression, non-compliance with study protocol, unacceptable major toxicity, at subject's own request for withdrawal, or if the study closes for any …

mg++
cancer chemotherapy
seminoma
teratoma
neutrophil count
  • 0 views
  • 10 Jun, 2021
  • 1 location
Adjuvant Bleomycin Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer

One course of adjuvant carboplatin AUC7 is considered internationally to be a standard treatment option in clinical stage I seminoma, regardless of risk factors. Treatment is based on a large

bleomycin
cancer chemotherapy
seminoma
neutrophil count
carboplatin
  • 15 views
  • 26 Jan, 2021
  • 2 locations
Trial to Evaluate Progression Free Survival With Primary Retroperitoneal Lymph-node Dissection (pRPLND) Only in Patients With Seminomatous Testicular Germ Cell Tumors With Clinical Stage IIA/B (PRIMETEST)

Primary objective: to evaluate progression-free survival in patients with clinical stage II A/B seminomatous germ cell tumor undergoing primary retroperitoneal lymph node dissection (RPLND) without adjuvant treatment Secondary objectives: overall survival perioperative complications (Clavien-Dindo score) quality of life (EORTC QLQ C30, EORTC QLQ TC26) long term sequelae rate of retrograde …

  • 3 views
  • 21 Jan, 2021
  • 1 location