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Found 12 clinical trials
  • 1 views
  • 21 Jan, 2021
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors

This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. Drugs used in chemotherapy, such as paclitaxel, ifosfamide, …

pegfilgrastim
chemotherapy drugs
progressive disease
stem cell transplantation
seminoma
  • 803 views
  • 03 Sep, 2021
  • 96 locations
Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle

. PURPOSE: This randomized phase III trial is comparing four different MRI and CT scan schedules in patients with stage I seminoma of the testicle.

ct scan
cancer
seminoma
  • 717 views
  • 07 Nov, 2020
  • 12 locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) Epithelial tumors of penis - squamous adenocarcinoma

MRI
iv infusion
octreotide
gilbert's syndrome
intrahepatic bile duct carcinoma
  • 6048 views
  • 22 Sep, 2021
  • 818 locations
Active Surveillance Bleomycin Carboplatin Etoposide or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as …

carcinoma
beta-human chorionic gonadotropin
bleomycin
seminoma
immature teratoma
  • 341 views
  • 08 Sep, 2021
  • 371 locations
Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma

The trial investigates a stage-adapted (stage IIA or IIB) de-escalation of the standard treatments in the context of a multimodality treatment with chemo- and radiotherapy in seminoma patients

renal function tests
cisplatin etoposide
fdg-pet
seminoma
etoposide
  • 14 views
  • 22 Sep, 2021
  • 20 locations
Evaluating Immune Therapy Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors

The purpose of this study is to test the safety and effectiveness of durvalumab with tremelimumab in patients with relapsed or refractory germ cell tumors.

beta-human chorionic gonadotropin
testosterone
periodic abstinence
progressive disease
brain metastases
  • 26 views
  • 26 Jan, 2021
  • 7 locations
A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

The purpose of the CTO-IUSCCC-0752 study is to investigate the use of Cabozantinib for patients with incurable, refractory germ cell tumors. Patients will be treated until evidence of disease progression, non-compliance with study protocol, unacceptable major toxicity, at subject's own request for withdrawal, or if the study closes for any …

beta-human chorionic gonadotropin
alpha fetoprotein
teratoma
cancer chemotherapy
seminoma
  • 0 views
  • 10 Jun, 2021
  • 1 location
Adjuvant Bleomycin Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer

One course of adjuvant carboplatin AUC7 is considered internationally to be a standard treatment option in clinical stage I seminoma, regardless of risk factors. Treatment is based on a large

alpha fetoprotein
cancer chemotherapy
bleomycin
seminoma
etoposide
  • 15 views
  • 26 Jan, 2021
  • 2 locations
A Study of miRNA 371 in Patients With Germ Cell Tumors

This trial studies whether the blood marker micro ribonucleic acid (miRNA) 371 can predict the chance of cancer returning in patients with germ cell cancers. Studying samples of blood from patients with germ cell cancers in the laboratory may help doctors predict how likely the cancer will come back.

beta-human chorionic gonadotropin
alpha fetoprotein
beta human chorionic gonadotropin
germ cell cancer
gonadotropin
  • 0 views
  • 07 May, 2021
  • 346 locations