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Found 12 clinical trials
  • 1 views
  • 08 Nov, 2020
Trial to Evaluate Progression Free Survival With Primary Retroperitoneal Lymph-node Dissection (pRPLND) Only in Patients With Seminomatous Testicular Germ Cell Tumors With Clinical Stage IIA/B (PRIMETEST)

Primary objective: to evaluate progression-free survival in patients with clinical stage II A/B seminomatous germ cell tumor undergoing primary retroperitoneal lymph node dissection (RPLND) without adjuvant treatment Secondary objectives: overall survival perioperative complications (Clavien-Dindo score) quality of life (EORTC QLQ C30, EORTC QLQ TC26) long term sequelae rate of retrograde …

  • 3 views
  • 08 Nov, 2020
  • 1 location
Nivolumab in Platinum Recurrent or Refractory Metastatic Germ Cell Tumors

To assess the clinical activity of nivolumab monotherapy, as measured by the investigator-assessed clinical benefit rate (CBR), in patients with platinum-recurrent or platinum-refractory metastatic germ cell tumors (GCT). CBR is defined by sum of complete responses (CR), partial responses (PR) and stable disease (SD) for at least 3 months, with …

mg++
progressive disease
tumor markers
high-dose chemotherapy
measurable disease
  • 19 views
  • 08 Nov, 2020
  • 1 location
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors

This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. Drugs used in chemotherapy, such as paclitaxel, ifosfamide, …

carboplatin
alpha fetoprotein
progressive disease
combinations
ifosfamide
  • 803 views
  • 17 Jan, 2021
  • 93 locations
Magnetic Resonance Imaging and Computed Tomography in Patients With Stage I Seminoma of the Testicle

. PURPOSE: This randomized phase III trial is comparing four different MRI and CT scan schedules in patients with stage I seminoma of the testicle.

seminoma
cancer
ct scan
  • 717 views
  • 07 Nov, 2020
  • 12 locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

>Transitional cell carcinoma other than that of the renal, pelvis, ureter, or bladder (closed to accrual) Cell tumor of the testes and extragonadal germ tumors: A) Seminoma and testicular

octreotide
remission
serous adenocarcinoma
neutrophil count
estimated creatinine clearance
  • 5957 views
  • 17 Jan, 2021
  • 793 locations
Active Surveillance Bleomycin Carboplatin Etoposide or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as …

carboplatin
mg++
neutrophil count
tumor cells
etoposide
  • 341 views
  • 27 Dec, 2020
  • 343 locations
Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma

The trial investigates a stage-adapted (stage IIA or IIB) de-escalation of the standard treatments in the context of a multimodality treatment with chemo- and radiotherapy in seminoma patients

renal function tests
carboplatin
neutrophil count
etoposide
cisplatin etoposide
  • 14 views
  • 21 Dec, 2020
  • 16 locations
Evaluating Immune Therapy Duravalumab (MEDI4736) With Tremelimumab for Relapsed/Refractory Germ Cell Tumors

The purpose of this study is to test the safety and effectiveness of durvalumab with tremelimumab in patients with relapsed or refractory germ cell tumors.

mg++
alpha fetoprotein
progressive disease
neutrophil count
medi4736
  • 26 views
  • 27 Nov, 2020
  • 7 locations
Adjuvant Bleomycin Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer

One course of adjuvant carboplatin AUC7 is considered internationally to be a standard treatment option in clinical stage I seminoma, regardless of risk factors. Treatment is based on a large

carboplatin
alpha fetoprotein
neutrophil count
etoposide
cancer chemotherapy
  • 15 views
  • 11 Nov, 2020
  • 1 location