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Found 11 clinical trials
  • 1 views
  • 21 Jan, 2021
Standard-Dose Combination Chemotherapy or High-Dose Combination Chemotherapy and Stem Cell Transplant in Treating Patients With Relapsed or Refractory Germ Cell Tumors

This randomized phase III trial studies how well standard-dose combination chemotherapy works compared to high-dose combination chemotherapy and stem cell transplant in treating patients with germ cell tumors that have returned after a period of improvement or did not respond to treatment. Drugs used in chemotherapy, such as paclitaxel, ifosfamide, …

combinations
pegfilgrastim
high-dose chemotherapy
carboplatin
tumor cells
  • 907 views
  • 25 Jul, 2022
  • 91 locations
Nivolumab and Ipilimumab in Treating Patients With Rare Tumors

tumors: A) Seminoma and testicular sex cord cancer B) Non seminomatous tumor C) Teratoma with malignant transformation (closed to accrual) Epithelial tumors of penis - squamous adenocarcinoma

carcinoid
chordoma
ipilimumab
amylase
adenocarcinoma
  • 6634 views
  • 10 Aug, 2022
  • 752 locations
Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance, bleomycin, etoposide, carboplatin or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as …

carcinoma
bleomycin
carboplatin
tumor cells
immature teratoma
  • 626 views
  • 29 Jul, 2022
  • 344 locations
Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma

The trial investigates a stage-adapted (stage IIA or IIB) de-escalation of the standard treatments in the context of a multimodality treatment with chemo- and radiotherapy in seminoma patients

fdg-pet
orchiectomy
seminoma
carboplatin
etoposide
  • 14 views
  • 12 Feb, 2022
  • 19 locations
A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

The purpose of the CTO-IUSCCC-0752 study is to investigate the use of Cabozantinib for patients with incurable, refractory germ cell tumors. Patients will be treated until evidence of disease progression, non-compliance with study protocol, unacceptable major toxicity, at subject's own request for withdrawal, or if the study closes for any …

cancer chemotherapy
seminoma
beta-human chorionic gonadotropin
mg++
tumor markers
  • 1 views
  • 08 Jul, 2022
  • 1 location
Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer (SWENOTECA-ABC)

One course of adjuvant carboplatin AUC7 is considered internationally to be a standard treatment option in clinical stage I seminoma, regardless of risk factors. Treatment is based on a large

cancer chemotherapy
bleomycin
orchiectomy
seminoma
carboplatin
  • 22 views
  • 08 Jul, 2022
  • 1 location
R-RPLND as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma

stage IIA/B (or equivalent) seminoma patients. R-RPLND will be trialed as an alternative to chemotherapy, radiation therapy (for seminoma patients) and open RPLND in this study.

  • 0 views
  • 04 Jun, 2022
  • 1 location
A Study of miRNA 371 in Patients With Germ Cell Tumors

This trial studies whether the blood marker micro ribonucleic acid (miRNA) 371 can predict the chance of cancer returning in patients with germ cell cancers. Studying samples of blood from patients with germ cell cancers in the laboratory may help doctors predict how likely the cancer will come back.

gonadotropin
germ cell cancer
testicular
cancer
beta-human chorionic gonadotropin
  • 0 views
  • 17 Nov, 2021
  • 378 locations
Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS

The majority of testicular cancer patients can be cured with cisplatin-based chemotherapy. Mortality has been reduced even more within the last 15 years due to the stringent application of standard chemotherapy followed by resection of residual disease. This is a positive development considering that testicular cancer usually affects young men. …

cardiovascular disease
seminoma
renal function tests
metastasis
  • 76 views
  • 09 Aug, 2021
  • 1 location