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Found 9 clinical trials
  • 1 views
  • 21 Jan, 2021
A Phase 3 Study of Active Surveillance for Low Risk and a Randomized Trial of Carboplatin vs. Cisplatin for Standard Risk Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumors has spread outside of the organ in which it developed, it is considered metastatic. Drugs used in chemotherapy, …

ct scan
seminoma
bleomycin
beta human chorionic gonadotropin
beta-human chorionic gonadotropin
  • 629 views
  • 28 Oct, 2022
  • 337 locations
R-RPLND as First-line Treatment for Clinical Stage IIA/B Testicular Seminoma

stage IIA/B (or equivalent) seminoma patients. R-RPLND will be trialed as an alternative to chemotherapy, radiation therapy (for seminoma patients) and open RPLND in this study.

  • 0 views
  • 04 Jun, 2022
  • 1 location
Reduced Intensity Radio-chemotherapy for Stage IIA/B Seminoma. A Multicenter, Open Label Phase II Trial With Two Cohorts

The trial investigates a stage-adapted (stage IIA or IIB) de-escalation of the standard treatments in the context of a multimodality treatment with chemo- and radiotherapy in seminoma patients

renal function tests
seminoma
cisplatin etoposide
orchiectomy
etoposide
  • 14 views
  • 12 Oct, 2022
  • 19 locations
Adjuvant Bleomycin, Etoposide and Cisplatin (BEP) Versus Carboplatin in Stage I Seminomatous Testicular Cancer (SWENOTECA-ABC)

One course of adjuvant carboplatin AUC7 is considered internationally to be a standard treatment option in clinical stage I seminoma, regardless of risk factors. Treatment is based on a large

seminoma
alpha fetoprotein
orchiectomy
bleomycin
etoposide
  • 22 views
  • 08 Jul, 2022
  • 2 locations
A Phase II Trial of Cabozantinib With Patients With Refractory GCTs

The purpose of the CTO-IUSCCC-0752 study is to investigate the use of Cabozantinib for patients with incurable, refractory germ cell tumors. Patients will be treated until evidence of disease progression, non-compliance with study protocol, unacceptable major toxicity, at subject's own request for withdrawal, or if the study closes for any …

seminoma
alpha fetoprotein
tumor markers
beta-human chorionic gonadotropin
mg++
  • 1 views
  • 08 Jul, 2022
  • 1 location
A Prospective Observational Cohort Study to Assess miRNA 371 for Outcome Prediction in Patients With Newly Diagnosed Germ Cell Tumors

This trial studies whether the blood marker micro ribonucleic acid (miRNA) 371 can predict the chance of cancer returning in patients with germ cell cancers. Studying samples of blood from patients with germ cell cancers in the laboratory may help doctors predict how likely the cancer will come back.

alpha fetoprotein
testicular
cancer
beta human chorionic gonadotropin
beta-human chorionic gonadotropin
  • 0 views
  • 11 Oct, 2022
  • 373 locations
Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS

The majority of testicular cancer patients can be cured with cisplatin-based chemotherapy. Mortality has been reduced even more within the last 15 years due to the stringent application of standard chemotherapy followed by resection of residual disease. This is a positive development considering that testicular cancer usually affects young men. …

renal function tests
seminoma
cardiovascular disease
metastasis
  • 76 views
  • 09 Aug, 2021
  • 1 location
MicroRNA as Markers in Testicular Cancer

The main objective of this study is establish the performance of miR371 in management of testicular cancer

  • 0 views
  • 04 Oct, 2022
  • 6 locations