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Found 18 clinical trials
International Trial of Selumetinib in Combination With Dexamethasone for the Treatment of Acute Lymphoblastic Leukaemia

This trial is to investigate the combination of selumetinib and dexamethasone in the treatment of acute lymphoblastic leukaemia (ALL) in both adults and children. Phase I is to find the most

graft versus host disease
dexamethasone
  • 80 views
  • 29 Jan, 2021
  • 21 locations
MEK 1/2 Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Adults With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas

the drug selumetinib (AZD6244 hydrogen sulfate) causes PNs to shrink or slows down their growth. Objectives To test if selumetinib helps treat PNs. To test how

nf1 mutation
peg-intron
plexiform neurofibroma
anticoagulant
gilbert disease
  • 259 views
  • 12 Sep, 2021
  • 1 location
SARC031: MEK Inhibitor Selumetinib (AZD6244) in Combination With the mTOR Inhibitor Sirolimus for Patients With Malignant Peripheral Nerve Sheath Tumors

To determine the clinical benefit rate of selumetinib in combination with sirolimus in patients with unresectable or metastatic neurofibromatosis type 1 (NF1) associated or sporadic MPNST.

absolute neutrophil count
platelet count
weakness
sirolimus
cancer
  • 37 views
  • 25 Jan, 2021
  • 4 locations
A Phase 2 Study of Osimertinib in Combination With Selumetinib in EGFR Inhibitor na ve Advanced EGFR Mutant Lung Cancer

study are: Osimertinib (Tagrisso) Selumetinib

pleural effusion
cancer chemotherapy
ct scan
epidermal growth factor
osimertinib
  • 8 views
  • 23 Aug, 2021
  • 3 locations
A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN)

A Phase 1 Open Label Study to Assess the Safety, Tolerability, Pharmacokinetics and Clinical Efficacy of Selumetinib, a Selective Mitogen Activated Protein Kinase Kinase (MEK) 1 Inhibitor, in

absolute neutrophil count
platelet count
gilbert disease
  • 0 views
  • 19 Sep, 2021
  • 1 location
A Study of the Drugs Selumetinib Versus Carboplatin/Vincristine in Patients With Neurofibromatosis and Low-Grade Glioma

This phase III trial studies if selumetinib works just as well as the standard treatment with carboplatin/vincristine (CV) for subjects with NF1-associated low grade glioma (LGG), and to see if

seizure
subependymal giant cell astrocytoma
tumor cells
cancer
selumetinib
  • 214 views
  • 19 Sep, 2021
  • 55 locations
Study of HL-085 in Patients With Advanced Solid Tumor Tumors

lower dose than selumetinib. It has been shown strong anti-tumor activities in preclinical studies to treat solid tumors, e.g., melanoma, non-small cell lung cancer, colon cancer and other malignancies

  • 0 views
  • 27 Mar, 2021
  • 5 locations
Systematically Assessing Changes in Plexiform Neurofibroma Related Disfigurement From Photographs of Subjects With Neurofibromatosis Type 1 on a Phase 2 Clinical Trial

. They can form anywhere in the body. They can become visible and cause deformations. Researchers want to see if selumetinib changes how PNs look in people with NF1. They also want to test a rating

plexiform neurofibroma
  • 0 views
  • 12 Sep, 2021
  • 1 location