Found 40 clinical trials
A Trial to Determine the Efficacy and Safety of Presendin in IIH (IIH EVOLVE)
Idiopathic intracranial hypertension (IIH) has significant associated morbidity and reduced quality of life. There is a significant risk of visual loss and patients also typically suffer with chronic disabling headaches. This trial has been designed to evaluate the efficacy and safety of a new formulation of exenatide (Presendin) in the …
- 0 views
- 06 Apr, 2023
- 4 locations
Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?
in the laboratory. Importantly, the investigators will evaluate whether propranolol counteracts stress-induced effects on alcohol self-administration. Following titration to steady state medication
- 11 views
- 22 Mar, 2022
- 1 location
Cocaine and Zolmitriptan
-administration). Although a robust preclinical literature supports the premise that 5-HT1b activation reduces a number of cocaine-associated behaviors (e.g., self-administration, cocaine seeking), this
- 0 views
- 16 Jun, 2022
- 1 location
Cigarette Smoking Decision Study
study will test the effect of greenwashing on behavioral economic demand and smoking topography in a laboratory-controlled cigarette self-administration study. These data will clearly connect tobacco
- 0 views
- 07 Oct, 2022
- 1 location
Nicotinic Receptor Genetic Variation and Alcohol Reward
Background People with the brain disease AUD (alcohol use disorder) have a serious problem with drinking. Researchers want to study how different people react to alcohol, and how genes affect this. They will focus on a nicotine receptor gene that may increase a person s AUD risk. Objectives To see …
- 66 views
- 12 Apr, 2023
- 1 location
A Pilot Trial To Assess The Feasibility And Efficacy Of SCIG In Patients With MG Exacerbation (SCIG-MG) (SCIG-MG)
This is a prospective open-label, uncontrolled, single-blind, pilot clinical trial. The primary objective is to assess the efficacy, safety, feasibility and tolerability of SCIG in patients with worsening MG. Participants with moderate worsening of MG symptoms (MGFA Class II and III) who are considered to be appropriate for immunoglobulin therapy …
- 0 views
- 16 Jun, 2022
- 2 locations
Computer-Assisted Self-Administration of Ethanol
precise blood levels is needed. In addition to testing this method of alcohol administration, the study will examine self-administration behavior and resulting breath alcohol concentration, the effects of
- 5 views
- 12 Apr, 2023
- 1 location
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes
The goal of this application is to test whether menthol and fruit flavors impact e-cigarette use through dissociable mechanisms and exert their effects differentially across nicotine doses.
- 0 views
- 24 Oct, 2022
- 1 location
A Multicentre, Non-Blinded Study Exploring Self-Administration of Chemotherapy in the Home Environment (EASE)
This study is to see if the standard of care subcutaneous injection of bortezomib can safely be administered at home by the patient or caregiver. All tests and assessments are based on standard of care procedures.
- 0 views
- 12 May, 2022
- 1 location
Title: Effect of Opioid Receptor Modulation on Alcohol Self-Administration and Neural Response to Alcohol Cues in Heavy Drinkers: Role of OPRM1 Gene Variation
Background Drugs like nalmefene interfere with opioid receptors. This might reduce drinking. The gene OPRM1 determines opioid receptor functions. Researchers want to see if nalmefene affects people s responses to alcohol cues. They also want to compare how nalmefene affects people with different forms of OPRM1. Objectives To test nalmefene …
- 9 views
- 03 Apr, 2023
- 1 location