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Found 1141 clinical trials
A Study to Evaluate the Efficacy Safety and Tolerability of Brivaracetam as Monotherapy in Patients 2 to 25 Years of Age With Childhood Absence Epilepsy or Juvenile Absence Epilepsy

The purpose of the study is to test the efficacy, safety and tolerability of brivaracetam monotherapy in study participants 2 to 25 years of age inclusive with childhood absence epilepsy (CAE) or juvenile absence epilepsy (JAE).

  • 21 Aug, 2021
  • 7 locations
Use of the "Game-Ready" Splint for Better Recovery in Primary Total Shoulder Arthroplasty

The aim of the study is to compare the level of postoperative pain after fitting the Game Ready splint, at 48 hours versus that observed with fitting a standard splint

  • 08 Jul, 2021
  • 1 location
A Pilot Study: Focused Ultrasound Thalamotomy for the Prevention of Secondary Generalization in Focal Onset Epilepsy

brain. This structure is known as the "Anterior Nucleus", and is an important region in the brain that may cause the seizures. Safety will be measured by recording and analyzing any adverse effects that

  • 25 Jan, 2021
  • 1 location
Safety Pharmacokinetics and Exploratory Efficacy Assessment of Adjunctive Cannabidiol Oral Solution (GWP42003-P) Compared With Standard of Care Antiepileptic Therapy in Patients Age 1 Month to <12 Months of Age With Tuberous Sclerosis Complex Who Experience Inadequately-controlled Seizures

This study will be conducted to evaluate the safety, tolerability, and pharmacokinetics of GWP42003-P compared with standard of care (SOC) antiepileptic drug (AED) assessed during the 17-week treatment period.

  • 06 Aug, 2021
  • 3 locations
Cardiovascular Responses in Adolescent Idiopathic Scoliosis Girls

The aims of this pilot study are to determine the metabolic demand and exercise intensity level of E-Fit exercise intervention by evaluating the cardiovascular responses in AIS girls and whether

  • 11 May, 2021
Ankle Foot Orthosis Comparative Effect

The proposed effort is designed to support evidence-based practice and optimal care by evaluating how the form, fit and function of two commercially available carbon fiber custom fit braces

  • 28 Jan, 2021
  • 3 locations
Biomarkers of Conversion Risk and Treatment Response in Early-Stage Schizophrenia

Schizophrenia (SZ) is a highly debilitating neuropsychiatric disorder of young adulthood onset and a leading cause of disability worldwide. While treatments delivered at early stages of the

  • 09 Aug, 2021
  • 1 location
Valproate Response in Aggressive Autistic Adolescents

This study will examine the effect of valproate, a medication used to treat seizures and bipolar disorder, on aggressive behavior in children and adolescents with autism.

bipolar disorder
  • 07 Nov, 2020
  • 1 location
Transparent Elastomeric Respirator for Aerosol-based Protection

reusable PPE that can be safely cleaned and sterilized. A novel reusable injection molded respirator will be evaluated using qualitative and quantitative fit tests to assess overall fit and comfort.

  • 14 Aug, 2021
  • 1 location
Efficacy of Modified Ketogenic Diet (Atkins) in Management of Epilepsy

The purpose of this study is to determine whether patients with uncontrolled epilepsy can follow a low carbohydrate diet long-term and if so, how will that diet affect their seizures

atkins diet
ketogenic diet
  • 07 Nov, 2020
  • 1 location