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Found 1156 clinical trials
Glucose Brain and Microbiota

The accumulation of iron is known to affect the functions of the liver, adipose tissue and muscle. The brain is a well-known place of iron deposition, which is associated with cognitive parameters of subjects with obesity. The hypothesis is that certain parameters related to glucose metabolism (glycemic variability, the circulating …

glycosylated hemoglobin
bariatric surgery
hemoglobin a1c
  • 24 Jul, 2021
  • 1 location
Results of the Aortic Valve Reconstruction in Children

Aortic valve disease counts up to 5% of cases of congenital heart disease being one of the most common congenital malformations of the cardiovascular system. This disease requires replacement of the damaged valve which in itself is not a trivial task to complete in children as there is still no …

computed tomography
supravalvular aortic stenosis
ejection fraction
congenital heart disease
  • 28 Feb, 2022
  • 1 location
Blood Management During ECMO for Cardiac Support (OBLEX)

Extracorporeal membrane oxygenation (ECMO) is a lifesaving procedure used to treat severe forms of heart and/or lung failure. It works by the principal of replacing the function of these organs by taking blood from the patient, provide it with oxygen outside the body and return it to the patient in …

membrane oxygenation
heart failure
heparin therapy
  • 12 May, 2022
  • 1 location
Genomic and Phenotypic Determinants of Resistance to Immunotherapies in Multiple Myeloma

A total of 40 Multiple Myeloma (MM) patients at clinical relapse who progressed during Proteasome Inhibitors (PIs) or Immunomodulating Drugs (IMiDs)-based therapies and who are assigned to antiCD38-based salvage treatments, will be enrolled. We will collect bone marrow (BM) and peripheral blood (PB) samples from patients at specific timepoints: baseline …

measurable disease
bone marrow procedure
  • 25 May, 2022
  • 1 location
CGRP Inhibition, Autonomic Function, and Migraine (CGRP-1)

The purpose of this clinical study is to better understand the function of the autonomic nervous system in patients with migraine. We aim to understand whether the autonomic functions change depending on the migraine status (i.e. whether they are between or during attacks) and whether the CGRP monoclonal antibody (mAb) …

Accepts healthy volunteers
  • 24 Apr, 2022
  • 1 location
Neuropsychological and Neuroimaging Evaluation of the Cognitive Impairment in Aortic Valve Replacement (ARTiCO) (ARTiCO)

OBJECTIVE: To evaluate changes in cognitive performance in the early postoperative (1 month) and late (1 year) postoperative period in patients undergoing aortic valve replacement (SVAo) with surgery (SVA_Q) or transcatheter aortic valve implant (TAVI), by neuropsychological study (NRP), structural Brain Magnetic Resonance (sMRI) and functional MRI (fMRI). The specific …

aortic valve replacement
transcatheter aortic valve implantation
  • 25 Mar, 2022
  • 1 location
Explorations of the Normal Neural Behavioral and Pathological Bases of Metacognition (METASENS)

Metacognition is the ability to introspect and report one's own mental states, or in other words to know how much one knows. It allows us to form a sense of confidence about decisions one makes in daily life, so one can commit to one option if our confidence is high, …

cognitive deficits
structured clinical interview
Accepts healthy volunteers
  • 25 Feb, 2022
  • 1 location
Inter-relationships Among Glucose, Brain, Gut Microbiota and MicroRNAs (IRONmiRNA). (IRONmiRNA)

The brain is a recognized target of iron deposition. This process is enhanced by the presence of obesity and hyperglycemia and impacts cognitive functions. There is evidence suggesting that the gut microbiota composition modulates this process. It has been proposed that microRNAs are mediators in the dialogue between the composition …

bariatric surgery
Accepts healthy volunteers
  • 16 May, 2022
  • 1 location
Comparison of the Cosmetic Results Quality of Life and Patient Satisfaction Achieved With Round-block and Retroglandular Oncoplastic Breast Conserving Surgeries

The aim of this clinical study is to analyze due long term follow-up, the clinical, oncological, aesthetic results and patients' reported quality of life and satisfaction in a responsive-adaptive (RAR) prospective, randomized study at a large number of patients whom receive round-block and retroglandular oncoplastic breast conserving surgeries. According to …

sentinel lymph node biopsy
breast-conserving surgery
sentinel node
breast surgery
  • 24 Jan, 2021
  • 1 location
Cortical Spreading Depolarization After Severe Traumatic Brain Injury

Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring neurosurgical intervention.

severe traumatic brain injury
traumatic brain injury
  • 13 Jun, 2022
  • 1 location