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Found 1128 clinical trials
Comparison of the Cosmetic Results Quality of Life and Patient Satisfaction Achieved With Round-block and Retroglandular Oncoplastic Breast Conserving Surgeries

The aim of this clinical study is to analyze due long term follow-up, the clinical, oncological, aesthetic results and patients' reported quality of life and satisfaction in a responsive-adaptive (RAR) prospective, randomized study at a large number of patients whom receive round-block and retroglandular oncoplastic breast conserving surgeries. According to …

sentinel lymph node biopsy
breast surgery
sentinel node
invasive breast cancer
  • 24 Jan, 2021
  • 1 location
Cortical Spreading Depolarization After Severe Traumatic Brain Injury

Preliminary evaluation of electrodes placed on the brain for recording brain activity and novel algorithms to determine cortical spreading depolarization foci of origination following severe traumatic brain injury requiring neurosurgical intervention.

traumatic brain injury
severe traumatic brain injury
  • 13 Jun, 2022
  • 1 location
A Balanced Reach Training Platform to Address Balance Disorders in Older and Neurologically Disabled Veterans

Falls are by far the leading cause of accidental injury and death in older adults. The Veteran population is more severely affected by falls since it is significantly older than the overall population (45% over 65 years of age vs. 13%); and Veterans would benefit substantially more from an accurate …

  • 28 Nov, 2021
  • 1 location
Multiomic Approach to Radioresistance of Ependymomas in Children and Adolescents

Treatment of childhood ependymoma, the second most frequent pediatric brain tumor, is based on surgery and radiation therapy. However, 50% relapse, mainly locally. Progress in imaging, molecular biology and radiotherapy ballistics has led us to propose the EPENDYMOMICS project, a multi-omics approach using artificial intelligence to detect the predictive characteristics …

  • 16 Dec, 2021
  • 1 location
TyrosIne Kinase Inhibitors in Chronic Myeloid Leukemia: Efficacy and Tolerability. The TIKlet Study (TIKlet)

Rationale The pharmacokinetics of imatinib and nilotinib, two BCR/Abl tyrosine-kinase inhibitors (TKI), is variable among patients suffering from chronic myeloid leukemia (CML). Transmembrane transporters may play a pivotal role in interindividual variability in TKI disposition. Furthermore, minimum plasma concentrations (Cmin) higher than 1 mg/L could be associated with a higher …

bcr-abl protein
  • 24 Mar, 2022
Juvenile Arthritis Quantitative Imaging (JAQI)

This observational study aims to develop and validate quantitative magnetic resonance imaging biomarkers as measures of disease activity in juvenile idiopathic arthritis (JIA). This includes patients with enthesitis-related arthritis (ERA).

Accepts healthy volunteers
  • 23 Feb, 2022
  • 1 location
PAthogen Transmission and Health Outcome Models of Enteric Disease (PATHOME)

The objective of the PATHOME study is to (1) develop statistical and computational methods for examining a complex disease system of interactions between and amongst children, animals, the environment, and enteric pathogens and (2) build a virtual laboratory for predicting which social and environmental developmental improvements best prevents multi-pathogen transmission …

  • 04 Oct, 2022
  • 1 location
Effect of Mepolizumab on Severe Eosinophilic Asthma (EMESEA)

Two parts: A:Case-control study including 15 healthy adult donors and 15 severe adult eosinophilic asthmatics selected for treatment with mepolizumab. B: A longitudinal cohort study,where the same patients once on mepolizumab treatment are followed over time (0, 4, 16 and 32 weeks). SCOPE: response to mepolizumab in severe adult eosinophilic …

Accepts healthy volunteers
  • 07 Oct, 2022
  • 2 locations