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Found 1079 clinical trials
Validation of the O-bridge Protocol: a Prospective Multicenter Trial

Surgical reconstruction to restore oral function and aesthetics after major ablative surgery in the oral cavity forms a challenge to maxillofacial surgeons, and greatly impacts patient' quality of life (QOL). The "Oncological-bridge (O-bridge)" protocol, which offers (immediate/delayed) fixed prosthetic rehabilitation in a minimum of sessions and a strongly reduced two-week …

  • 29 Jan, 2021
  • 6 locations
Nerve Transfer After Spinal Cord Injury- Multi-center

Current treatment strategies of acute cervical spinal cord injuries remain limited. Treatment options that provide meaningful improvements in patient quality of like and long-term functional independence will provide a significant public health impact. Specific aim: Measure the efficacy of nerve transfer surgery in the treatment of patients with complete spinal …

nerve transfer
electrical stimulation
spinal cord
spinal cord disorder
  • 18 Sep, 2021
  • 7 locations
Evaluation of Long-term Incidence of Ventricular Arrhythmias in Patients With Acute Myocarditis

Myocarditis is an inflammatory disease of the heart muscle which is mostly caused by viruses, bacteria, parasites, toxic substances/drugs or by primary autoimmune mechanisms. Signs of heart failure (dyspnea, reduced resilience, tendency to edema), thoracic pain, palpitations / arrhythmias / syncope, as well as (potentially) lethal clinical conditions in the …

  • 24 Jan, 2021
Nifedipine Dosing Daily vs Twice a Day for Pre-eclampsia With Severe Features (NOPPI)

The investigators propose a randomized controlled unblinded trial to evaluate rates of optimal blood pressure control between Nifedipine 60mg XL once daily vs. Nifedipine 30mg XL twice daily in patients admitted for expectant management with pre-eclampsia with severe features. Patients will be approached for consent when they are placed on …

  • 22 Dec, 2021
  • 1 location
Peritoneal Lavage Liquid Biopsy in Patients With Gastric Cancer

This study investigates the prognostic role of liquid biopsy in patients with locally advanced gastric cancer. Liquid biopsy for the detection of circulating tumor DNA will be performed: In the peritoneal lavage, during staging laparoscopy (if indicated) and during curative gastrectomy In plasma, before staging laparoscopy (if indicated), before curative …

adjuvant therapy
  • 08 Jul, 2021
  • 1 location
Apoptosis Markers in Aggressive Periodontitis

The aim of the present trial is to assess the gingival crevicular fluid level of caspase-3 and apoptosis inducing factor (AIF) in Generalized versus Molar-incisor grade C periodontitis. The present study will be carried out on patients selected from those attending on the outpatient clinics of Department of Oral Medicine, …

  • 19 Aug, 2021
  • 1 location
Study of Selected X-Linked Disorders: Aicardi Syndrome

Based on our current understanding of Aicardi syndrome, the condition is hypothesized to occur due to a genetic change on the X-chromosome. Our team is investigating Aicardi syndrome to identify the specific gene location associated with the disorder. We are collecting blood and skin biopsy samples from patients and their …

  • 23 Jan, 2022
  • 1 location
World Data on Ambroxol for Patients With GD and GBA Related PD

Ambroxol hydrochloride is an oral mucolytic drug available over-the-counter for many years as cough medicine. In 2009 it was found to also act as a pharmacological chaperone (PC) for mutant glucocerebrosidase, albeit in a several-fold higher dose. Unfortunately, due to its low cost, there have been no pharma-driven clinical trials …

  • 25 Jan, 2022
  • 2 locations
The Effects of Posture on Cerebral Blood Flow Velocity During the Acute Phase of Stroke

After stroke, blood vessels in the brain can become damaged, and the brain's ability to control blood flow can be impaired. The brain therefore may be less able to maintain a healthy level of blood flow during challenges such as changes in posture. Studies have shown that sitting upright early …

  • 11 Nov, 2021
  • 1 location
Imaging Biomarkers in Parkinson s Disease

Background Parkinson s disease (PD) causes slow movement, stiffness, and tremor. It results from the loss of a brain chemical called dopamine. PD gets worse over time, but researchers do not fully understand why the brain cells that produce dopamine stop working or die in people with PD. This study …

Accepts healthy volunteers
cognitive decline
  • 25 Jan, 2022
  • 1 location