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Found 92 clinical trials
Randomized Trial of Sedative Choice for Intubation (RSI)

tracheal intubation have been hypothesized to effect cardiovascular complications and patient outcomes, but the optimal sedative medication for intubation of critically ill adults remains unknown. Ketamine

  • 04 Oct, 2022
  • 1 location
Effect of Intravenous S-ketamine on Opioid Consumption

Female patients with an American Society of Anesthesia (ASA) physical status I-II, scheduled for elective breast cancer surgery will be included in the study. Subjects will be randomly assigned to one of three groups: the placebo group, the low-dose S-ketamine group, and the high-dose S-ketamine group. The primary outcome is …

  • 04 Oct, 2022
  • 1 location
National Adaptive Trial for PTSD Related Insomnia (NAP)

Many Veterans with posttraumatic stress disorder (PTSD) have trouble sleeping or have frequent nightmares. So far, no medication has been approved for treatment of insomnia in PTSD. The purpose of this research study is to find out if taking medications called trazodone, eszopiclone, or gabapentin can help decrease symptoms of …

poor sleep
continuous positive airway pressure
behavior therapy
wake up
  • 27 Jun, 2022
  • 34 locations
Pragmatic Trial Examining Oxygenation Prior to Intubation (PREOXI)

Clinicians perform rapid sequence induction, laryngoscopy, and tracheal intubation for more than 5 million critically ill adults as a part of clinical care each year in the United States. One-in-ten emergency tracheal intubations is complicated by life-threatening hypoxemia. Administering supplemental oxygen prior to induction and intubation ("preoxygenation") decreases the risk …

  • 04 Oct, 2022
  • 10 locations
SEdative-Hypnotic Deprescribing Assisted by a Technology-Driven Insomnia InterVEntion (SEDATIVE) (SEDATIVE)

Chronic insomnia is one of the most common health problems among Veterans and significantly impacts their health, function, and quality of life. Sedative-hypnotic medications are the most common

behavior therapy
cognitive therapy
cognitive behavioral therapy for insomnia
  • 27 Oct, 2022
  • 1 location
The Effect of Intraoperative Dexmedetomidine on Postoperative Morphine Requirements After Breast Cancer Surgery

Dexmedetomidine is an α2 receptor agonist with sedative and analgesic properties. In previous reports, dexmedetomidine improves smoothness of postoperative recovery and reduces intraoperatory

  • 26 May, 2022
  • 1 location
Jackson Pediatric Acupressure for Opioid Tapering

older infants exposed to prolonged medications (greater than 5 days) for cardiac procedures that may cause withdrawal upon cessation such as opioids, benzodiazepines, or other sedative medications

  • 15 Jun, 2022
  • 1 location
Music Therapy in Procedural Sedation in the Emergency Department

music vs no music by headphones so that the investigator is blinded to the intervention. The outcome variable is amount of sedative used and self-reported anxiety level as reported on a 10 point visual

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
Study on the Efficacy of Vetiver Essential Oil Aroma on Depression/Anxiety People

In this study, subjects with depression/anxiety inhaled the essential oil, which contained sedative, soothing, and relaxing active ingredients to stimulate the olfactory nerve. The essential oil

  • 09 Jul, 2022
  • 1 location
Phase I Clinical Trial to Determine the Safety of Clonidine in Infants With HIE During Therapeutic Hypothermia.

receptors are more effective at reducing postoperative shivering than opioid receptor agonists and provide analgesia and sedation without respiratory depression. The most desirable sedative-analgesic

  • 08 Nov, 2020
  • 1 location