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Found 31 clinical trials
Pembrolizumab and Decitabine With or Without Venetoclax in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome That Is Newly-Diagnosed, Recurrent, or Refractory

This phase Ib trial studies the side effects and best dose of pembrolizumab and how well it works in combination with decitabine with or without venetoclax in treating patients with acute myeloid leukemia or myelodysplastic syndrome that is newly-diagnosed, has come back (recurrent), or does not respond to treatment (refractory). …

lymphoma
leukemia
carbon monoxide
stem cell transplantation
induction chemotherapy
  • 0 views
  • 09 Apr, 2022
  • 1 location
Total Marrow and Lymphoid Irradiation, Fludarabine, and Melphalan Before Donor Stem Cell Transplant in Treating Participants With High-Risk Acute Leukemia or Myelodysplastic Syndrome

This phase I studies the side effects and best dose of total marrow and lymphoid irradiation when given together with fludarabine and melphalan before donor stem cell transplant in treating participants with high-risk acute leukemia or myelodysplastic syndrome. Giving chemotherapy, such as fludarabine and melphalan, and total marrow and lymphoid …

carbon monoxide
leukemia
tyrosine
stem cell transplantation
etoposide
  • 17 views
  • 10 Mar, 2022
  • 1 location
Phase I Study of Hu8F4 in Patients With Advanced Hematologic Malignancies

This phase I trial studies the side effects and best dose of anti-PR1/HLA-A2 monoclonal antibody Hu8F4 (Hu8F4) in treating patients with malignancies related to the blood (hematologic). Monoclonal antibodies, such as Hu8F4, may interfere with the ability of cancer cells to grow and spread.

raeb
leukemia
myelofibrosis
chronic myeloid leukemia
antibody therapy
  • 17 views
  • 13 Oct, 2022
  • 3 locations
A Phase II Study of CPX-351 Monotherapy in Acute Myeloid Leukemia (CPX-351 TA-SMP)

-myelodysplastic syndrome (MDS) and post-MPN secondary AML in terms of disease resistance to chemotherapy, of fragile patient profile, The hypotheses made is that CPX-351 may improve the results of induction

cell transplantation
consolidation therapy
cytarabine
cytarabine/daunorubicin
daunorubicin
  • 0 views
  • 23 Oct, 2022
  • 18 locations
Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia

RATIONALE: Giving chemotherapy, such as busulfan, fludarabine, and melphalan, before a donor umbilical cord blood stem cell transplant helps stop the growth of abnormal or cancer cells and prepares the patient's bone marrow for the stem cells. When the healthy stem cells from a donor are infused into the patient …

raeb
leukemia
stem cell transplantation
bone marrow procedure
fludarabine
  • 37 views
  • 22 Mar, 2022
  • 1 location
Cladribine, Idarubicin, Cytarabine, and Venetoclax in Treating Patients With Acute Myeloid Leukemia, High-Risk Myelodysplastic Syndrome, or Blastic Phase Chronic Myeloid Leukemia

This phase II trial studies how well cladribine, idarubicin, cytarabine, and venetoclax work in patients with acute myeloid leukemia, high-risk myelodysplastic syndrome, or blastic phase chronic myeloid leukemia. Drugs used in chemotherapy, such as cladribine, idarubicin, cytarabine, and venetoclax, work in different ways to stop the growth of cancer cells, …

midostaurin
leukemia
refractory acute myeloid leukemia (aml)
secondary aml
chronic myeloid leukemia
  • 42 views
  • 17 Mar, 2022
  • 1 location
Monitoring, Detoxifying, and Rebalancing Metals During Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Therapy

This phase I trial studies the side effects and best dose of edetate calcium disodium or succimer in treating patients with acute myeloid leukemia or myelodysplastic syndrome undergoing chemotherapy. Edetate calcium disodium or succimer may help to lower the level of metals found in the bone marrow and blood and …

secondary acute myeloid leukemia
leukemia
refractory acute myeloid leukemia (aml)
tubal ligation
succimer
  • 10 views
  • 18 Oct, 2022
  • 1 location
Personalized NK Cell Therapy After Chemotherapy and Cord Blood Transplant in Treating Patients With Myelodysplastic Syndrome, Leukemia, Lymphoma or Multiple Myeloma

This phase II clinical trial studies how well personalized natural killer (NK) cell therapy works after chemotherapy and umbilical cord blood transplant in treating patients with myelodysplastic syndrome, leukemia, lymphoma or multiple myeloma. This clinical trial will test cord blood (CB) selection for human leukocyte antigen (HLA)-C1/x recipients based on …

cyclophosphamide
lymphoblastic leukemia
leukemia
total body irradiation
tyrosine
  • 58 views
  • 05 Jul, 2022
  • 1 location
Study of APVO436 in Patients With AML or MDS

The primary objective of the Phase 1 part of the study is to determine the recommended dose of APVO436 administered intravenously to patients with AML or MDS. The primary objective of the Phase 1b part of the study is to evaluate the clinical activity of APVO436 in patients with AML …

leukemia
flow cytometry
refractory acute myeloid leukemia (aml)
myelodysplasia
consolidation therapy
  • 81 views
  • 23 Mar, 2022
  • 9 locations
A Phase IIa, Open-label, Clinical Trial to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, and Efficacy of BP1001 (a Liposomal Grb2 Antisense Oligonucleotide) in Combination With Venetoclax Plus Decitabine in Patients With AML Who Are Ineligible for Intensive Induction Therapy

The primary objectives of this study are to assess: (1) whether the combination of BP1001 plus venetoclax plus decitabine provides greater efficacy (Complete Remission [CR], Complete Remission with incomplete hematologic recovery [CRi], Complete Remission with partial hematologic recovery [CRh], than venetoclax plus decitabine alone (by historical comparison) in participants with …

refractory acute myeloid leukemia (aml)
blast cells
decitabine
remission
leukapheresis
  • 4 views
  • 14 Oct, 2022
  • 4 locations