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Found 9 clinical trials
Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia

The purpose of this study is to determine the feasibility of comparing outcomes of patients treated de novo with immunosuppressive therapy (IST) versus matched unrelated donor (MUD) hematopoietic stem cell transplant (HSCT) for pediatric acquired severe aplastic anemia.

aplastic anemia
horse anti-thymocyte globulin
hla-a
rabbit atg
antithymocyte globulin
  • 28 views
  • 25 Jan, 2021
  • 13 locations
Study for Patients With Newly Diagnosed High-risk Acute Promyelocytic Leukemia

are associated with significant toxicities due to severe myelosuppression frequently associated with life-threatening infections and potentially serious late effects including development of secondary

arsenic
cytarabine
monoclonal antibody
mitoxantrone
methotrexate
  • 0 views
  • 23 Jan, 2021
  • 8 locations
Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant

This randomized clinical trial studies different chemotherapies in treating patients with myelodysplastic syndrome before donor stem cell transplant. Giving chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells, and may prevent the …

secondary myelodysplastic syndrome
white blood cell count
myelodysplastic syndromes
myelomonocytic leukemia
azacitidine
  • 21 views
  • 27 Jan, 2021
  • 4 locations
Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

This phase I trial studies the side effects and best dose of ipilimumab when given together with decitabine in treating patients with myelodysplastic syndrome or acute myeloid leukemia that has returned after a period of improvement (relapsed) or does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as …

myelodysplastic syndromes
ipilimumab
refractory acute myeloid leukemia (aml)
immunodeficiency
gilbert's syndrome
  • 187 views
  • 21 Apr, 2021
  • 6 locations
Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia

RATIONALE: Giving chemotherapy, such as busulfan, fludarabine, and melphalan, before a donor umbilical cord blood stem cell transplant helps stop the growth of abnormal or cancer cells and prepares the patient's bone marrow for the stem cells. When the healthy stem cells from a donor are infused into the patient …

melphalan
ejection fraction
white blood cell count
myelodysplastic syndromes
busulfan
  • 37 views
  • 29 Jan, 2021
  • 1 location
Fludarabine Phosphate Cyclophosphamide Total Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

This phase II trial studies how well fludarabine phosphate, cyclophosphamide, total body irradiation, and donor stem cell transplant work in treating patients with blood cancer. Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the …

transplant conditioning
ejection fraction
white blood cell count
diamond-blackfan anemia
glanzmann's thrombasthenia
  • 134 views
  • 24 Jan, 2021
  • 1 location
Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)

The purpose of this study is to determine if AR-67 is effective in the treatment for patients with MDS.

chronic myelomonocytic leukemia
leukemia
hydroxyurea
myelomonocytic leukemia
decitabine
  • 30 views
  • 08 Nov, 2020
  • 1 location
Ibrutinib Fludarabine Phosphate Cyclophosphamide and Obinutuzumab in Treating Patients With Chronic Lymphocytic Leukemia

This phase II trial studies how well ibrutinib, fludarabine phosphate, cyclophosphamide, and obinutuzumab work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work …

lymphoid leukemia
platelet count
lymphoma
obinutuzumab
monoclonal protein
  • 0 views
  • 25 Jan, 2021
  • 1 location
Haploinsufficiency of the RBM22 and SLU7 Genes in Del(5q) Myelodysplastic Syndromes

acute myeloid leukemia (AML) is variable. Acquired cytogenetic abnormalities are found in less than 50% of de novo cases and up to 80% in secondary MDS. The deletion of the long arm of chromosome 5

  • 0 views
  • 28 Jan, 2021
  • 3 locations