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Found 11 clinical trials
Unrelated Donor Transplant Versus Immune Therapy in Pediatric Severe Aplastic Anemia

The purpose of this study is to determine the feasibility of comparing outcomes of patients treated de novo with immunosuppressive therapy (IST) versus matched unrelated donor (MUD) hematopoietic stem cell transplant (HSCT) for pediatric acquired severe aplastic anemia.

reticulocyte count
rabbit atg
antithymocyte globulin
cyclophosphamide
methotrexate
  • 28 views
  • 08 Aug, 2021
  • 13 locations
Study for Patients With Newly Diagnosed High-risk Acute Promyelocytic Leukemia

are associated with significant toxicities due to severe myelosuppression frequently associated with life-threatening infections and potentially serious late effects including development of secondary

serum bilirubin
anthracyclines
tretinoin
myeloid leukemia
methotrexate
  • 0 views
  • 26 Aug, 2021
  • 8 locations
Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant

This randomized clinical trial studies different chemotherapies in treating patients with myelodysplastic syndrome before donor stem cell transplant. Giving chemotherapy before a donor stem cell transplant helps stop the growth of cancer cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells, and may prevent the …

bone marrow procedure
leukemia
secondary myelodysplastic syndrome
chronic myelomonocytic leukemia
myelodysplastic syndromes
  • 21 views
  • 27 Jul, 2021
  • 4 locations
Ipilimumab and Decitabine in Treating Patients With Relapsed or Refractory Myelodysplastic Syndrome or Acute Myeloid Leukemia

This phase I trial studies the side effects and best dose of ipilimumab when given together with decitabine in treating patients with myelodysplastic syndrome or acute myeloid leukemia that has returned after a period of improvement (relapsed) or does not respond to treatment (refractory). Immunotherapy with monoclonal antibodies, such as …

secondary aml
remission
myeloid leukemia
immunodeficiency
immunosuppressive agents
  • 187 views
  • 17 Sep, 2021
  • 6 locations
Hematopoietic Stem Cell Transplantation in the Treatment of Infant Leukemia

RATIONALE: Giving chemotherapy, such as busulfan, fludarabine, and melphalan, before a donor umbilical cord blood stem cell transplant helps stop the growth of abnormal or cancer cells and prepares the patient's bone marrow for the stem cells. When the healthy stem cells from a donor are infused into the patient …

bone marrow procedure
flow cytometry
ejection fraction
PCR test
combination chemotherapy
  • 37 views
  • 29 Jan, 2021
  • 1 location
Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

This phase I trial studies the side effects and best dose of edetate calcium disodium or succimer in treating patients with acute myeloid leukemia or myelodysplastic syndrome undergoing chemotherapy. Edetate calcium disodium or succimer may help to lower the level of metals found in the bone marrow and blood and …

chronic myeloid leukemia
bone marrow procedure
leukemia
calcium
myeloid leukemia
  • 10 views
  • 08 Aug, 2021
  • 1 location
Fludarabine Phosphate Cyclophosphamide Total Body Irradiation and Donor Stem Cell Transplant in Treating Patients With Blood Cancer

This phase II trial studies how well fludarabine phosphate, cyclophosphamide, total body irradiation, and donor stem cell transplant work in treating patients with blood cancer. Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work in different ways to stop the growth of cancer cells, either by killing the …

bone marrow procedure
chromosome abnormalities
ejection fraction
secondary myelodysplastic syndrome
immunodeficiency
  • 134 views
  • 05 Aug, 2021
  • 1 location
Abemaciclib and Niraparib Before Surgery for the Treatment of Hormone Receptor Positive HER2 Negative Breast Cancer

This phase I trial tests the side effects and best dose of abemaciclib and niraparib in treating patients with breast cancer that is positive for estrogen or progesterone receptors (hormone receptor positive [HR+]) and HER2 negative. Abemaciclib may stop the growth of tumor cells by blocking certain proteins called cyclin-dependent …

  • 0 views
  • 09 Jul, 2021
  • 1 location
Study of AR-67 (DB-67) in Myelodysplastic Syndrome (MDS)

The purpose of this study is to determine if AR-67 is effective in the treatment for patients with MDS.

decitabine
leukemia
myelomonocytic leukemia
chronic myelomonocytic leukemia
azacitidine
  • 30 views
  • 08 Nov, 2020
  • 1 location
Ibrutinib Fludarabine Phosphate Cyclophosphamide and Obinutuzumab in Treating Patients With Chronic Lymphocytic Leukemia

This phase II trial studies how well ibrutinib, fludarabine phosphate, cyclophosphamide, and obinutuzumab work in treating patients with chronic lymphocytic leukemia. Ibrutinib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as fludarabine phosphate and cyclophosphamide, work …

cyclophosphamide
monoclonal protein
lymphoma
obinutuzumab
fludarabine
  • 0 views
  • 29 Jul, 2021
  • 1 location