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Found 34 clinical trials
The Role of Ruxolitinib in Secondary Acute Myelogenous Leukemia Evolving From Myeloproliferative Neoplasm

This trial aimed to investigate the therapeutic efficacy of ruxolitinib in combination with cytotoxic chemotherapy for post-myeloproliferative neoplasm secondary acute myeloid leukemia.

  • 1 views
  • 24 Jan, 2021
  • 2 locations
Efficacy of G-CSF-Priming in Elderly AML Patients

versus the same IdAV chemotherapy only followed by G-CSF (without priming) in elderly patients with de novo AML, secondary AML and advanced MDS. Moreover, the ability to mobilize sufficient

cytarabine
secondary acute myeloid leukemia
consolidation therapy
granulocyte colony stimulating factor
idarubicin
  • 50 views
  • 07 Nov, 2020
  • 1 location
Dose-Reduced Versus Standard Conditioning Prior Allo SCT for MDS/sAML Patients

unrelated donors in patients with MDS or secondary AML. The hypothesis is that dose-reduced conditioning will reduce the non-relapse mortality from 40% to 20% at one year after allogeneic stem

cyclophosphamide
busulfan
cell transplantation
fludarabine
  • 28 views
  • 07 Nov, 2020
  • 1 location
CD8 Depleted Non-engrafting HLA Mismatched Unrelated Infusion With MDS and Secondary AML

The purpose of the study is to determine the safety of an investigational treatment for myelodysplastic syndrome (MDS) after the first therapy (such as azacitidine or decitabine) stops working or after progression of MDS to acute myeloid leukemia (AML).

  • 0 views
  • 24 Mar, 2021
  • 1 location
CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old

This phase II trial studies how well liposome-encapsulated daunorubicin-cytarabine (CPX-351) works in treating patients with secondary acute myeloid leukemia who are younger than 60 years old

ejection fraction
daunorubicin
cytarabine
myeloid leukemia
cancer
  • 0 views
  • 25 Jan, 2021
  • 1 location
Efficacy and Pharmacogenomics of Salvage CLAG-M Chemotherapy in Patients With Relapse/Refractory and Secondary Acute Myeloid Leukemia

This is a prospective phase II clinical study to be conducted at the Medical College of Wisconsin. After meeting the study criteria and enrollment, patients will be treated with Cladribine, Cytarabine, Mitoxantrone, G-CSF (CLAG-M) chemotherapy and followed at periodic intervals to determine the primary and secondary objectives.

ejection fraction
cytarabine
direct bilirubin
filgrastim
granulocyte colony stimulating factor
  • 28 views
  • 09 Apr, 2021
  • 1 location
Lenalidomide in Treating Patients With High Risk Acute Myeloid Leukemia in Remission

This phase II trial studies how well lenalidomide works in treating patients with acute myeloid leukemia that have had a decrease in or disappearance of signs and symptoms of cancer, although cancer still may be in the body and may be likely to come back or spread. Biological therapies, such …

induction chemotherapy
myeloid leukemia
cancer
flow cytometry
hematologic disorder
  • 42 views
  • 26 Jan, 2021
  • 2 locations
A Study of CG-806 in Patients With Relapsed or Refractory Acute Myeloid Leukemia

This study is being done to evaluate the safety, tolerability and antitumor activity of oral CG-806 for the treatment of patients with Acute Myeloid Leukemia (except APML), secondary AML, or

acute promyelocytic leukemia
secondary acute myeloid leukemia
refractory acute myeloid leukemia (aml)
  • 0 views
  • 26 Jan, 2021
  • 4 locations
TP-0903 for the Treatment of FLT3 Mutated Acute Myeloid Leukemia

This phase IB/II trial studies the best dose of TP-0903 and how well it works when given alone or with azacitidine in treating patients with FLT3 gene mutated acute myeloid leukemia. TP-0903 may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Chemotherapy …

  • 0 views
  • 27 Jan, 2021
  • 1 location
Integrating Geriatric Assessment and Genetic Profiling to Personalize Therapy Selection in Older Adults With Acute Myeloid Leukemia

This phase II trial of the impact of clinicogenetic risk-stratified management on outcomes of acute myeloid leukemia in older patients is to determine the rate of complete remission and mortality at 90 days in the entire cohort of older patients (60 years) with newly diagnosed acute myeloid leukemia, who receive …

daunorubicin
cytarabine
venetoclax
decitabine
azacitidine
  • 4 views
  • 24 Jan, 2021
  • 2 locations