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Found 19 clinical trials
Optimization of Preoperative Treatment in Locally Advanced Rectal Cancer

The purpose of this study is to compare effectiveness of short-term radiotherapy with neoadjuvant chemotherapy(TNT group) with preoperative long-term chemoradiotherapy(CRT group) in locally advanced rectal cancer. The hypothesis is 3-year disease-free survival in TNT group was non-inferior to that in CRT group.

chemoradiotherapy
adenocarcinoma
pelvic mri
adenocarcinoma of rectum
  • 0 views
  • 21 Jul, 2021
  • 1 location
MRI Screening of Second Primary Cancer Occurring Within Radiation Fields After Treatment by External Beam Radiation Therapy for Hereditary Retinoblastoma (DepiSCARRH) (DepiSCARRH)

The purpose of this study is to assess the benefit of MR screening for asymptomatic head & neck (or CNS) second primary cancers occurring in hereditary retinoblastoma patients previously

second primary cancer
cancer
beam radiation
bilateral retinoblastoma
  • 28 views
  • 24 Feb, 2022
  • 1 location
Carbon Ion Re-Radiotherapy in Patients With Recurrent or Progressive Locally Advanced Head-and-Neck Cancer

After multimodal therapy of head-and-neck tumors, patients often develop local recurrence, locally progressive disease or second primary tumors. In this highly pre-treated patient cohort

  • 2 views
  • 18 Oct, 2021
  • 1 location
PD-1 Antibody for The Prevention of Adenomatous Polyps and Second Primary Tumors in Lynch Syndrome Patients

This study aims to explore the role of PD-1 Antibody in preventing adenomatous polyps and second primary tumors in patients with Lynch Syndrome. There two arms, one is the experimental arm (PD-1

  • 0 views
  • 29 Jan, 2021
  • 1 location
Exploring the Application Value of PET Molecular Imaging Targeting FAP in Oral Squamous Cell Carcinoma (FAPI-OSCC)

metastases, distant metastases and second primary tumors are important for determining the therapeutic strategy and prognosis of oral cancer. Currently, the molecular imaging agent most commonly used in

squamous cell carcinoma
positron emission tomography
metastasis
carcinoma
oral cancer
  • 0 views
  • 23 Mar, 2022
  • 1 location
HFHS-1801-A Pilot Study of Immunotherapy as Consolidation Therapy for Patients With Recurrent Head and Neck Cancer

The study is a pilot study to explore the feasibility and efficacy of immunotherapy following salvage surgery for recurrent head and neck cancer.

cancer
head and neck carcinoma
carcinoma
neck cancer
definitive treatment
  • 0 views
  • 19 Feb, 2022
  • 1 location
Intensity-Modulated Proton Beam Therapy or Intensity-Modulated Photon Therapy in Treating Patients With Stage III-IVB Oropharyngeal Cancer

This randomized phase II/III trial studies the side effects and how well intensity-modulated proton beam therapy works and compares it to intensity-modulated photon therapy in treating patients with stage III-IVB oropharyngeal cancer. Radiation therapy uses high-energy x-rays, protons, and other types of radiation to kill tumor cells and shrink tumors. …

oropharyngeal
carcinoma
metastasis
tumor cells
cancer of the head
  • 41 views
  • 30 May, 2022
  • 14 locations
Whole-body DW-MRI and cfDNA Analysis for the Surveillance of Melanoma Patients at High Risk for Recurrence.

Patients with locally advanced melanoma are at high risk for recurrence following surgical treatment. More patients with stage IV melanoma remain in complete remission following systemic therapy. No standards have been established for the surveillance of patients at high risk for recurrence. Whole-body diffusion-weighted magnetic resonance imaging and cfDNA analysis …

metastatic melanoma
systemic therapy
advanced melanoma
  • 8 views
  • 26 Jan, 2021
  • 3 locations
SPT Screening in Irradiated Hereditary Retinoblastoma Survivors

Rationale: Hereditary retinoblastoma survivors have an increased risk to develop second primary tumors (SPT) at a later age (with the highest risk in their teens), especially when they have

cancer
anesthesia
  • 12 views
  • 08 Nov, 2020
  • 1 location
Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients With Inflammatory or Invasive Breast Cancer

This trial studies the biospecimen and medical data collection in creating a research tissue registry in patients with inflammatory or invasive breast cancer. Collecting medical data and storing samples of blood, tissue, and stool from patients with inflammatory breast cancer to study in the laboratory may help doctors find better …

inflammatory breast cancer
invasive breast cancer
mastectomy
breast carcinoma
core needle biopsy
  • 88 views
  • 10 May, 2022
  • 5 locations