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Found 60 clinical trials
Registry Study of Revcovi Treatment in Patients With ADA-SCID

The objective of this study is to develop a registry of patients with adenosine deaminase severe combined immune deficiency (ADA-SCID) treated with Revcovi that contains clinical and biochemical

elapegademase-lvlr
ada deficiency
revcovi
adenosine deaminase
undernutrition
  • 0 views
  • 15 Jul, 2021
  • 10 locations
Genetic Basis of Immunodeficiency

This study will examine the role of hereditary factors in different forms of severe combined immunodeficiency (SCID). Patients with immunodeficiencies may be eligible for this study

  • 3 views
  • 12 Sep, 2021
  • 2 locations
Long Term Follow Up Of Patients Who Have Received Gene Therapy Or Gene Marked Products

This protocol (GENEFU) provides a mechanism for the 15-year followup period that the FDA requires for all participants in gene transfer protocols and assures that adequate followup can be maintained for a wide variety of participants on different individual gene therapy protocols at St. Jude Children's Research Hospital. GENEFU serves …

blood disorder
late effects
primary cancer
gene therapy
venipuncture
  • 22 views
  • 27 Jan, 2021
  • 1 location
Establishing Fibroblast-Derived Cell Lines From Skin Biopsies of Patients With Immunodeficiency or Immunodysregulation Disorders

Background National Institutes of Health (NIH) researchers have been studying immune cells (white blood cells) to better understand how the human body s defense system works and adjusts or regulates itself, and how changes in this system can make a person sick. To study the cells of patients who have …

immune disorder
genetic tests
genetic testing
immunodeficiency
  • 115 views
  • 07 Sep, 2021
  • 1 location
Role of SLURP-1 in Melanoma and Melanoma Stem Cells

. 2.Higher frequencies of cells capable of initiating melanoma xenografts when using IL2R-/- NOD SCID mice. These data confirmed the interaction between T cells and MSCs. In this project, we

lymphocyte antigen
cancer
metastatic melanoma
  • 10 views
  • 08 Nov, 2020
A German Multicenter Study on Toxoplasma Gondii in First-episode Schizophrenia

validity such as the SCID and the PANSS. Exposure to cats, other warm-blooded life-stock, and raw meat will be assessed using a special questionnaire.

psychiatric disorder
scid
schizophrenia
schizophreniform disorder
antibody titers
  • 11 views
  • 07 Nov, 2020
  • 2 locations
Survey on Patients After Childbearth Following Bariatric Surgery

Women with a history of bariatric surgery may face various difficulties during pregnancy and puerperal time. Therefore it is assumed the prevalence of mental health disorders might be higher than in average women during and after pregnancy. This could possibly lead to an unsatisfying weight progress and therapeutic non-adherence. These …

  • 1 views
  • 24 Jan, 2021
  • 4 locations
Metabolic Profiling of Immune Responses in Immune-mediated Diseases

Background The immune system is the part of the body that fights infection. Some people have immune deficiencies that cause skin rashes, make them get sick often with infections, or make it difficult for their skin to heal. Researchers want to learn more to better treat conditions that affect immune …

eczema
psoriasis
  • 0 views
  • 19 Aug, 2021
  • 1 location
The Neural Bases of Emotion Regulation in Bulimia Nervosa

This project aims to explore emotional processing and regulation in individuals with Bulimia Nervosa (BN) with a view to better understand its underlying causes. Previous research suggests that binge eating and purging behaviours may be linked to difficulties with emotions and impulses. However, most of the research has been conducted …

purging
bulimia nervosa
alexithymia
eating disorder
  • 111 views
  • 04 Jul, 2021
  • 2 locations
Neuroinflammation Affective and Cognitive Symptoms in Major Depression and Psoriasis

Objectives: To identify peripheral neuroinflammatory markers in patients suffering from major depression or psoriasis in relation to affective symptoms (anxiety, depression, irritability), fatigue and cognitive symptoms; and their change after specific treatments. Methodology: Observational prospective cohort study in patients diagnosed with major depression and patients with plaque psoriasis, who naturalistically …

  • 0 views
  • 13 Feb, 2021
  • 1 location