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Found 61 clinical trials
Addressing Heavy Alcohol Use Consumption With Kudzu (A-HACK)

Drinking multiple alcoholic drinks on a single occasion (binge drinking), has many negative health risks but interventions to address this behavior remain limited. This double-blind, placebo-controlled randomized clinical trial will test whether kudzu, an herbal supplement, can reduce heavy alcohol use and alcohol-associated sexual behaviors among sexually-active, binge-drinking individuals at …

drug abuse
scid
Accepts healthy volunteers
antibody response
HIV Infection
  • 64 views
  • 10 Aug, 2022
  • 1 location
Feasibility Trial of Tele-IPT and Tele-Pharmacotherapy for Patients With Depression and Non-Metastatic Breast Cancer (IPT)

Cancer and depression commonly occur together, and each worsens the other. We conducted a large psychotherapy study treating depression in breast cancer patients, showing that psychotherapy lowers symptoms. Surprisingly, no studies have compared depression-focused psychotherapy to antidepressant medication for patients with breast cancer and depression. We applied to the National …

  • 0 views
  • 06 Apr, 2022
  • 1 location
Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders

Preclinical and clinical data as well as mechanistic justification have been presented suggesting citicoline and pregnenolone are each promising treatments for alcohol use in BPD. Both appear to have favorable side effect profiles and no known drug-drug interactions. Thus, they have the potential to be safely used in a dual …

mood stabilizer
oxcarbazepine
atypical antipsychotic
carbamazepine
schizoaffective disorder
  • 1218 views
  • 25 Jul, 2022
  • 1 location
Online Group Therapy for Breast Cancer

Breast cancer is a serious and life-threatening health problem that is increasing all over the world and in Turkey. Although the survival rate increases with the improvement of the diagnosis and treatment processes for breast cancer, cancer patients experience some psychosocial problems both due to their treatment and the disease. …

  • 0 views
  • 08 Mar, 2022
  • 1 location
Exercise and COVID-19 Viral T-cell Immunity

Viruses are a major health problem for the general public and at risk populations. Normally, detection of antibody titers is the gold standard for determining the effectiveness of the immune system following natural or vaccine caused immunization. However, determining the effectiveness of other parts of the immune system are less …

antibody test
Accepts healthy volunteers
PCR test
vaccination
  • 0 views
  • 06 Oct, 2021
  • 1 location
Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

Background Severe aplastic anemia (SAA) and myelodysplastic syndrome (MDS) are bone marrow diseases. People with these diseases usually need a bone marrow transplant. Researchers are testing ways to make stem cell transplant safer and more effective. Objective To test if treating people with SAA or MDS with a co-infusion of …

stem cell transplantation
blood test
anemia
neutropenia
immunosuppressant
  • 12 views
  • 22 Jul, 2022
  • 1 location
Integrated Care in Psychotic Disorders With Severe Mental Illness

The study examine the effectiveness of an integrated care program including therapeutic assertive community treatment (ACT) for people with psychotic disorders fulfilling severe and persistent mental illness (SPMI, ACCESS-II study).

schizoaffective disorder
shared psychotic disorder
delusions
bipolar disorder
schizophrenia
  • 100 views
  • 06 Oct, 2021
  • 1 location
Pioglitazone for the Treatment of Alcohol Use Disorder (PAUSE)

Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best. Pioglitazone, a medication FDA approved for diabetes, has been shown in pre-clinical studies to reduce alcohol. The proposed study will test the efficacy of …

antidepressants
diabetes
heavy drinking
scid
  • 29 views
  • 01 May, 2022
  • 2 locations
Mirtazapine and Methamphetamine Drug-drug Interaction Study

This is a drug-drug interaction (DDI) study of mirtazapine for methamphetamine (MA) use disorder (MUD) to ensure the safety of this medication in the presence of a relevant dose of MA for people actively-using MA. Aim 1: To determine if mirtazapine alters the cardiovascular response to IV MA. Aim 2: …

electrocardiogram
  • 18 views
  • 02 Sep, 2021
  • 3 locations
Optimal Treatment of Veterans With PTSD and Comorbid OUD

The objective of this study is to test a standard psychotherapy for PTSD in Veterans who also suffer from Opiate Use Disorder (OUD). Specifically, this study will test whether Cognitive Processing Therapy (CPT)-C is more effective in treating PTSD, compared to a control group (Individual Drug Counseling (IDC); which approximates …

opiates
scid
cognitive therapy
psychotherapy
opioid
  • 15 views
  • 02 May, 2022
  • 2 locations