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Found 60 clinical trials
Autologous Ex Vivo Expanded Regulatory T Cells in Ulcerative Colitis

Together with Crohn's disease (CD), ulcerative colitis (UC) is one of the major forms of inflammatory bowel diseases (IBD).Currently, no curative therapy is available, since the pathophysiology of this disease is incompletely understood (1-3) and clinical practice demonstrates that current therapies induce remission in subgroups of patients only. Scientific evidence …

crohn's disease
corticosteroids
azathioprine
budesonide
prednisone
  • 0 views
  • 16 Sep, 2021
  • 1 location
Clinical Medication Development for Bipolar Disorder and Alcohol Use Disorders

Preclinical and clinical data as well as mechanistic justification have been presented suggesting citicoline and pregnenolone are each promising treatments for alcohol use in BPD. Both appear to have favorable side effect profiles and no known drug-drug interactions. Thus, they have the potential to be safely used in a dual …

substance use
valproate
schizoaffective disorder
valproic acid
carbamazepine
  • 1148 views
  • 29 Aug, 2021
  • 2 locations
Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS Using CordIn(TM) Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

Background Severe aplastic anemia (SAA) and myelodysplastic syndrome (MDS) are bone marrow diseases. People with these diseases usually need a bone marrow transplant. Researchers are testing ways to make stem cell transplant safer and more effective. Objective To test if treating people with SAA or MDS with a co-infusion of …

neutropenia
umbilical cord blood transplantation
aplastic anemia
neutrophil count
immunosuppression
  • 12 views
  • 19 Aug, 2021
  • 1 location
Suvorexant in the Management Comorbid Sleep Disorder and Alcohol Dependence

Suvorexant (trade name Belsomra) is an orexin receptor antagonist that has TGA approval for the treatment of insomnia, characterised by difficulties with sleep onset and/or sleep maintenance. It may also have a role in addictions as the orexins play a critical role in drug addiction and reward-related behaviours. Orexins appear …

sleep disorder
suvorexant
  • 0 views
  • 27 Aug, 2021
  • 1 location
Optimal Treatment of Veterans With PTSD and Comorbid OUD

The objective of this study is to test a standard psychotherapy for PTSD in Veterans who also suffer from Opiate Use Disorder (OUD). Specifically, this study will test whether Cognitive Processing Therapy (CPT)-C is more effective in treating PTSD, compared to a control group (Individual Drug Counseling (IDC); which approximates …

opioid
cognitive therapy
opiates
scid
psychotherapy
  • 15 views
  • 15 May, 2021
  • 2 locations
Pioglitazone for the Treatment of Alcohol Use Disorder

Alcohol Use Disorder (AUD) is common among Veterans but medication treatment is used infrequently and the impact of these treatments are small to moderate at best. Pioglitazone, a medication FDA approved for diabetes, has been shown in pre-clinical studies to reduce alcohol. The proposed study will test the efficacy of …

antidepressants
heavy drinking
diabetes
scid
  • 29 views
  • 08 May, 2021
  • 2 locations
Mirtazapine and Methamphetamine Drug-drug Interaction Study

This is a drug-drug interaction (DDI) study of mirtazapine for methamphetamine (MA) use disorder (MUD) to ensure the safety of this medication in the presence of a relevant dose of MA for people actively-using MA. Aim 1: To determine if mirtazapine alters the cardiovascular response to IV MA. Aim 2: …

electrocardiogram
  • 0 views
  • 02 Sep, 2021
  • 3 locations
Exercise and Total Viral Immunity

Viruses are a major health problem for the general public and at risk populations. Normally, detection of antibody titers is the gold standard for determining the effectiveness of the immune system following natural or vaccine caused immunization. However, determining the effectiveness of other parts of the immune system are less …

vaccination
PCR test
antibody test
  • 0 views
  • 01 Sep, 2021
  • 1 location
Prairie Loin Pain Hematuria Syndrome Renal Denervation Study: A Feasibility Study

Loin Pain Hematuria Syndrome (LPHS) is a poorly understood, painful and incapacitating condition that typically afflicts young women and was first described in 1967. Currently, the treatment for LPHS is opioid prescription and in some extreme cases, surgical denervation of the nociceptive impulses with renal auto transplantation and auto nephrectomy. …

  • 15 views
  • 25 Mar, 2021
  • 1 location
Scopolamine in Bipolar Depression

This is a single-site, randomised, double-blind, placebo-controlled, parallel, phase IIb clinical trial. The primary objective of the SCOPE-BD study is to investigate the efficacy and safety of IV Scopolamine, compared to placebo, in reducing severity of depression in individuals with bipolar disorder who are experiencing a depressive episode of at …

  • 0 views
  • 16 May, 2021
  • 1 location