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Found 60 clinical trials
Adjunctive Vortioxetine in Schizophrenia

with a research diagnosis of schizophrenia determined with the Structured Clinical Interview for DSM (SCID). Patient randomization will be stratified by illness duration (i.e., </=5 years and >5

cognitive symptoms
benzodiazepines
antipsychotics
scid
delusions
  • 70 views
  • 22 Feb, 2021
  • 3 locations
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

This is a standard of care treatment guideline for allogeneic hematopoetic stem cell transplant (HSCT) in patients with primary immune deficiencies.

immunodeficiency
cd40l
primary immunodeficiency
langerhans cell histiocytosis
x-linked lymphoproliferative disease
  • 265 views
  • 27 Jan, 2021
  • 1 location
Immune Disorder HSCT Protocol

This study hypothesizes that a reduced intensity immunosuppressive preparative regimen will establish engraftment of donor hematopoietic cells with acceptable early and delayed toxicity in patients with immune function disorders. A regimen that maximizes host immune suppression is expected to reduce graft rejection and optimize donor cell engraftment.

immunosuppressants
hsct
colony stimulating factor
treatment regimen
immunosuppression
  • 123 views
  • 24 Jan, 2021
  • 2 locations
The Use Of L-Methylfolate As A Treatment For Depression

to moderate MDD based on the Structured Clinical Interview for DSM-IV (SCID) that have a Hamilton Depression Rating Scale-24 (HDRS-24) score between 8-24. The investigators will collect genotype data

antidepressants
scid
depressed mood
structured clinical interview
major depressive disorder
  • 166 views
  • 14 Jun, 2021
  • 1 location
Conditioning Regimen for Allogeneic Hematopoietic Stem-Cell Transplantation

In this study, the investigators test 2 dose levels of thiotepa (5 mg/kg and 10 mg/kg) added to the backbone of targeted reduced dose IV busulfan, fludarabine and rabbit anti-thymocyte globulin (rATG) to determine the minimum effective dose required for reliable engraftment for subjects undergoing hematopoietic stem cell transplantation for …

immunodeficiency
ratg
anti-thymocyte globulin (rabbit)
malnutrition
shortening fraction
  • 176 views
  • 19 Jul, 2021
  • 1 location
Application of UP for Transdiagnostic Treatment of Emotional Disorders for UHR for Psychosis Patients

at six months follow-up and will include: general psychopathology (SCID), anxiety and depression (BDI-II, BAI), positive and negative emotions (PANAS), personality (NEO-FFI), functionality (EEASL

depression
scid
  • 0 views
  • 20 Jul, 2021
  • 2 locations
Effectiveness of the First French Psychoeducational Program on Unipolar Depression

Background. Major Depressive Disorder (MDD) is highly prevalent and was associated with greater morbidity, mortality (including suicide), and healthcare costs. By 2030, MDD will become the leading cause of disability in high-income countries. Notably, among patients with a previous experience of a major depressive episode, it was indeed estimated that …

  • 0 views
  • 26 Jan, 2021
  • 1 location
Group Metacognitive Therapy vs Clinical Management for Depression

The main aims of the study are to (1) compare the effectiveness of Group metacognitive therapy (GMCT) treatment to that of clinical management and (2) explore patterns of change and investigate factors associated with treatment outcome

depression
  • 2 views
  • 22 Jan, 2021
  • 1 location
Alpha/Beta T and CD19+ Depleted Peripheral Stem Cells for Patients With Primary Immunodeficiencies

This is a Phase II trial to determine the ability of a reduced intensity conditioning regimen to allow successful engraftment with alpha/beta T and CD19+ depleted peripheral stem cell grafts from unrelated or partially matched related donors. There are two conditioning regimens depending upon patient diagnosis and age.

histiocytosis
reduced intensity conditioning
stem cell transplantation
shortening fraction
allogeneic hematopoietic stem cell transplant
  • 3 views
  • 24 Jan, 2021
  • 1 location
Addressing Heavy Alcohol Use Consumption With Kudzu

Drinking multiple alcoholic drinks on a single occasion (binge drinking), has many negative health risks but interventions to address this behavior remain limited. This double-blind, placebo-controlled randomized clinical trial will test whether kudzu, an herbal supplement, can reduce heavy alcohol use and alcohol-associated sexual behaviors among sexually-active, binge-drinking individuals at …

scid
HIV Infection
drug abuse
antibody response
heavy drinking
  • 58 views
  • 19 Mar, 2021
  • 1 location