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Found 61 clinical trials
Blended Care Versus Face-to-Face Therapy for Depression (BLENDED)

Depression is a severe mental disorder that affects 5-7% of Belgians each year. Unfortunately, many individuals with depression do not seek professional help, and if they do seek professional help, waiting lists for psychotherapy are typically very long. To help resolve this problem, this study aims to investigate whether blended …

anxiety
behavior modification
psychiatric disorder
psychotic symptoms
cognitive therapy
  • 10 views
  • 03 Mar, 2022
  • 5 locations
JSP191 Antibody Targeting Conditioning in SCID Patients

A Phase 1/2 study to evaluate the safety, tolerability, and efficacy of an antibody conditioning regimen, known as JSP191, in patients with Severe Combined Immune Deficiency undergoing blood

transplant conditioning
primary immunodeficiency
cell transplantation
monoclonal antibodies
undernutrition
  • 3 views
  • 24 Feb, 2022
  • 8 locations
Haplocompatible Transplant Using TCRα/β Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)

Infants with severe combined immunodeficiency (SCID) have a profound decrease in number and function of immune cells, and therefore remain highly vulnerable to infection. If not corrected this

glomerular filtration rate
thiotepa
busulfan
cell transplantation
apheresis
  • 2 views
  • 05 Mar, 2022
  • 1 location
Autologous Gene Therapy for Artemis-Deficient SCID

This study aims to determine if a new method can be used to treat Artemis-deficient Severe Combined Immunodeficiency (ART-SCID), a severe form of primary immunodeficiency caused by mutations in

tetanus
busulfan
gene therapy
primary immunodeficiency
cell transplantation
  • 0 views
  • 10 Mar, 2022
  • 1 location
Gene Therapy for X Linked Severe Combined Immunodeficiency

A safety and efficacy clinical study of a lentiviral vector to transfer IL2RG complementary DNA to bone marrow stem cells in ten children with genetic diagnosed X-SCIDsevere combined immune deficiency .The ten children will be followed for 3-5 years and be evaluated by clinical characteristics, vector marking (vector copy number …

  • 0 views
  • 28 Feb, 2022
  • 1 location
Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants (LVXSCID-ND)

SCID-X1 is a genetic disorder of blood cells caused by DNA changes in a gene that is required for the normal development of the human immune system. The purpose of this study is to determine if

  • 26 views
  • 25 Mar, 2022
  • 3 locations
Phase I/II Clinical Trial Stem Cell Gene Therapy in RAG1-Deficient SCID

This study is a prospective, non-randomized, open-label, two-centre phase I/II intervention study designed to treat children up to 24 months of age with RAG1-deficient SCID with an indication

  • 0 views
  • 22 Dec, 2021
  • 1 location
Phase I/II Trial of Lentiviral Gene Transfer for SCID-X1 With Low Dose Targeted Busulfan Conditioning

This is a phase I/II open label multi-center study in which patients will receive low dose targeted busulfan followed by infusion of autologous CD34+ selected bone marrow or mobilized peripheral blood cells transduced with the G2SCID vector. Subjects will be enrolled over 3 years and be followed for 2 years …

  • 26 views
  • 23 Jul, 2022
  • 5 locations
  • 0 views
  • 05 Mar, 2022
Allogeneic Hematopoietic Stem Cell Transplant for Patients With Primary Immune Deficiencies

This is a standard of care treatment guideline for allogeneic hematopoetic stem cell transplant (HSCT) in patients with primary immune deficiencies.

cd40 ligand
omenn's syndrome
hemophagocytic lymphohistiocytosis
histiocytosis
severe combined immunodeficiency
  • 313 views
  • 29 Apr, 2022
  • 1 location