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Found 60 clinical trials
Conditioning SCID Infants Diagnosed Early

The investigators want to study if lower doses of chemotherapy will help babies with SCID to achieve good immunity with less short and long-term risks of complications after transplantation

  • 0 views
  • 15 Sep, 2021
  • 20 locations
JSP191 Antibody Targeting Conditioning in SCID Patients

A Phase 1/2 study to evaluate the safety, tolerability, and efficacy of an antibody conditioning regimen, known as JSP191, in patients with Severe Combined Immune Deficiency undergoing blood

primary immunodeficiency
monoclonal antibodies
cell transplantation
undernutrition
transplant conditioning
  • 3 views
  • 10 Jun, 2021
  • 8 locations
Autologous Gene Therapy for Artemis-Deficient SCID

This study aims to determine if a new method can be used to treat Artemis-deficient Severe Combined Immunodeficiency (ART-SCID), a severe form of primary immunodeficiency caused by mutations in

primary immunodeficiency
busulfan
undernutrition
tetanus
igiv
  • 0 views
  • 25 Jan, 2021
  • 1 location
Haplocompatible Transplant Using TCR / Depletion Followed by CD45RA-Depleted Donor Lymphocyte Infusions for Severe Combined Immunodeficiency (SCID)

Infants with severe combined immunodeficiency (SCID) have a profound decrease in number and function of immune cells, and therefore remain highly vulnerable to infection. If not corrected this

busulfan
severe combined immunodeficiency
ejection fraction
fludarabine
transplant conditioning
  • 2 views
  • 22 Aug, 2021
  • 1 location
Gene Therapy for X Linked Severe Combined Immunodeficiency

A safety and efficacy clinical study of a lentiviral vector to transfer IL2RG complementary DNA to bone marrow stem cells in ten children with genetic diagnosed X-SCIDsevere combined immune deficiency .The ten children will be followed for 3-5 years and be evaluated by clinical characteristics, vector marking (vector copy number …

  • 0 views
  • 25 Jan, 2021
  • 1 location
Gene Transfer for X-Linked Severe Combined Immunodeficiency in Newly Diagnosed Infants

SCID-X1 is a genetic disorder of blood cells caused by DNA changes in a gene that is required for the normal development of the human immune system. The purpose of this study is to determine if

  • 26 views
  • 28 Jan, 2021
  • 3 locations
Lentiviral Gene Transfer for Treatment of Children Older Than Two Years of Age With X-Linked Severe Combined Immunodeficiency (XSCID)

This is a non-randomized clinical trial of gene transfer using a self-inactivating, insulated, lentiviral gene transfer vector to treat 23 patients with X-linked severe combined immunodeficiency

  • 0 views
  • 15 Sep, 2021
  • 1 location
Phase I/II Clinical Trial Stem Cell Gene Therapy in RAG1-Deficient SCID

This study is a prospective, non-randomized, open-label, two-centre phase I/II intervention study designed to treat children up to 24 months of age with RAG1-deficient SCID with an indication

  • 0 views
  • 04 Apr, 2021
  • 1 location
Phase I/II Trial of Lentiviral Gene Transfer for SCID-X1 With Low Dose Targeted Busulfan Conditioning

This is a phase I/II open label multi-center study in which patients will receive low dose targeted busulfan followed by infusion of autologous CD34+ selected bone marrow or mobilized peripheral blood cells transduced with the G2SCID vector. Subjects will be enrolled over 3 years and be followed for 2 years …

  • 24 views
  • 30 Apr, 2021
  • 5 locations
  • 0 views
  • 25 Apr, 2021
  • 1 location