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Found 54 clinical trials
Unrelated Umbilical Cord Blood Transplantation for Severe Aplastic Anemia and Hypo-plastic MDS using CordIn(TM), Umbilical Cord Blood-Derived Ex Vivo Expanded Stem and Progenitor Cells to Expedite Engraftment and Improve Transplant Outcome

Background: Severe aplastic anemia (SAA) and myelodysplastic syndrome (MDS) are bone marrow diseases. People with these diseases usually need a bone marrow transplant. Researchers are testing ways to make stem cell transplant safer and more effective. Objective: To test if treating people with SAA or MDS with a co-infusion of …

myelodysplastic syndrome (mds)
aplastic anemia
myelodysplastic syndromes
anemia studies
  • 22 Dec, 2020
  • 1 location
Lentiviral Gene Therapy for X-linked Severe Combined Immunodeficiency

Severe combined immunodeficiency disorder (SCID) is a heterogeneous group of inherited disorders characterized by a profound reduction or absence of T lymphocyte function, resulting in lack of

  • 18 Feb, 2021
  • 1 location
Gene Transfer for ADA-SCID Using an Improved Lentiviral Vector (TYF-ADA)

Gene transfer for ADA-SCID using an improved lentiviral vector (TYF-ADA)

  • 23 Jan, 2021
  • 1 location
Ezetimibe as a Safe and Efficacious Treatment for Chronic Hepatitis C

To address the need for more affordable hepatitis C virus (HCV) antivirals with high barriers to viral resistance and strategies to shorten the current treatment duration, the goal is to develop affordable therapeutic regimens to prevent HCV entry/spread and test the efficacy of those inhibitors for treating HCV infection. The …

chronic hepatitis
liver disease
antiviral drugs
  • 26 Jan, 2021
  • 1 location
Prevention of OUD: The HOME Project (Housing Opportunities Motivation and Engagement)

Homeless youth have a much higher rate of substance use than non-homeless peers with evidence suggesting that homeless youth have the highest rates of opioid use among youth subgroups in the country (Brands et al., 2005); heroin using homeless youth also appear to have the highest rates of IV drug …

  • 03 Mar, 2021
  • 1 location
Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

The goal of this proposal is to test the overall hypothesis that e-cigarettes (ECs) provide efficient nicotine delivery to the brain and arterial blood in non-EC-nave smokers and e-cigarette users and that EC liquid characteristics modulate this effect. This study will test the hypothesis through complementary methods that include [ …

  • 25 Jan, 2021
  • 1 location
Follow-up Study With Clinical Vitamin D Supplementation Trial on Patients With Depression (DepFuD)

information. All participants give blood samples for biomarker analyses at time points 3, 6, 18 months and 5 years. Clinical interviews of mental disorders (e.g. SCID) and anthropometric measurements (e.g

recurrent depression
depressed mood
major depressive disorder
  • 23 Jan, 2021
  • 1 location
Blended Care Versus Face-to-Face Therapy for Depression

Depression is a severe mental disorder that affects 5-7% of Belgians each year. Unfortunately, many individuals with depression do not seek professional help, and if they do seek professional help, waiting lists for psychotherapy are typically very long. To help resolve this problem, this study aims to investigate whether blended …

behavior modification
psychotic symptoms
  • 24 Jan, 2021
  • 5 locations
Conditioning SCID Infants Diagnosed Early

The investigators want to study if lower doses of chemotherapy will help babies with SCID to achieve good immunity with less short and long-term risks of complications after transplantation

  • 03 Mar, 2021
  • 17 locations
JSP191 Antibody Targeting Conditioning in SCID Patients

A Phase 1 study to evaluate the safety and tolerability of an antibody conditioning regimen, known as JSP191, in patients with Severe Combined Immune Deficiency undergoing blood stem cell

cell transplantation
transplant conditioning
primary immunodeficiency
monoclonal antibodies
  • 28 Jan, 2021
  • 6 locations