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Found 45 clinical trials
A Prospective, Multi-center, Randomized Controlled Blinded Trial Demonstrating the Safety and Effectiveness of VNS Therapy® System as Adjunctive Therapy Versus a No Stimulation Control in Subjects With Treatment-Resistant Depression (RECOVER)

Objectives of this study are to determine whether active VNS Therapy treatment is superior to a no stimulation control in producing a reduction in baseline depressive symptom severity, based on multiple depression scale assessment tools at 12 months from randomization.

depressive episode
depressive disorder
depressive symptoms
  • 07 Oct, 2022
  • 65 locations
Sex Differences in the Dilatory Response of Compound 21

When blood pressure changes, Angiotensin II is produced and released into the bloodstream. This substance can make blood vessels smaller (i.e., vasoconstriction) by acting through Angiotensin II type I receptors (AT1R) to increase blood pressure. Or it can increase the diameter of vessels (i.e., vasodilation) through Angiotensin II type II …

Accepts healthy volunteers
  • 24 Oct, 2022
  • 1 location
An Open-Label Dose-Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of mRNA-3745 in Participants With Glycogen Storage Disease Type 1a (GSD1a)

The main goal of this trial is to evaluate the safety and tolerability of mRNA-3745 via intravenous (IV) administration in participants with GSD1a.

  • 29 Oct, 2022
  • 6 locations
  • 11 Oct, 2022
  • 3 locations
The Effect of Hyperbaric Oxygen Treatment in Patients With Osteoradionecrosis.

Osteoradionecrosis (ORN) is a severe delayed radiation-induced injury that can occur in patients whom have been subjected to radiotherapy for head and neck cancer. Hyperbaric oxygen treatment (HBO) is one treatment option. In Sweden it is used in some locations in combination to standard treatment which includes for example antibiotics, …

  • 28 Jun, 2021
  • 2 locations
Mobile Health for Alcohol Use Disorders in Clinical Practice

This study evaluates the impact on risky drinking days and quality of life for patients with alcohol use disorder among patients who use a mobile health smart phone application. A third of the participants will receive access to the smart phone app without any monitoring; a third of the participants …

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
Helping Patients and Providers Make Better Decisions About Colorectal Cancer Screening

Precision prevention holds great promise for colorectal cancer (CRC) screening but has not been adequately explored. A patient's chance of having an advanced colorectal neoplasm (ACN), i.e. a cancer or precancerous polyp in the colon, significantly affects the comparative effectiveness of approved tests. Giving patients a decision aid with information …

  • 04 Oct, 2022
  • 1 location
  • 16 Oct, 2022
  • 9 locations
  • 14 Oct, 2022
  • 8 locations
A Prospective Multicenter Longitudinal Cohort Study of the Mymobility Platform

Post-market prospective, multi-center longitudinal study to determine if mobile application-guided education and exercise paired with accurate and sensitive activity monitoring, captured from consumer wearables, can provide a viable (and potentially improved) alternative to current standard of care physical therapy for hip and knee arthroplasty.

hip arthroplasty
partial knee replacement
total knee replacement
  • 28 Oct, 2022
  • 28 locations