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Found 22 clinical trials
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2

This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with neurofibromatosis type 2 (NF2) with associated progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas. This Master Study is being conducted as a "basket" study that may allow …

acoustic neuroma
neurofibromatosis type 2
nf2 gene
measurable disease
multiple meningiomas
  • 06 May, 2021
  • 4 locations
Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas

Subjects with Neurofibromatosis Type 2 (NF2) and progressive vestibular schwannoma (VS) will be treated with crizotinib administered orally. Crizotinib will be taken continuously until disease

neurofibromatosis type 2
absolute neutrophil count
MRI Scan
measurable disease
  • 10 Feb, 2021
  • 14 locations
Immunotherapy Based on Antigen-specific Immune Effector Cells Targeting Neurofibromatosis or Schwannomatosis

immune modified dendritic cell vaccine (DCvac) in the treatment of neurofibromatosis or schwannoma.

neutrophil count
primary cancer
gilbert's syndrome
bone marrow procedure
  • 25 Jan, 2021
  • 2 locations
AM-125 in the Treatment of Acute Peripheral Vertigo Following Neurosurgery

and safety of AM-125 in the treatment of acute vertigo. In this proof of concept trial patients experiencing vertigo after neurosurgery (vestibular schwannoma labyrinthectomy and vestibular neurectomy

peripheral vertigo
acute vertigo
  • 13 May, 2021
  • 1 location
Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors

In this research study the researchers want to learn more about the effects (both good and bad) the study drug selumetinib has on participants with neurofibromatosis type II (NF2) related tumor. The researchers are asking patients with NF2 related tumors to be in the study, because their hearing has decreased …

growth factor
monoclonal antibodies
blood transfusion
platelet count
  • 24 Jan, 2021
  • 1 location
Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors the HiPPI Study

This phase II trial studies how well hypofractionated proton or photon radiation therapy works in treating patients with brain tumors. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells. A shorter duration of radiation treatment may avoid some …

tumor cells
  • 02 Jun, 2021
  • 1 location
Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy

> This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.

viral vector
gene therapy
  • 26 Jan, 2021
  • 5 locations
Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology

The first proton therapy treatments in the Netherlands have taken place in 2018. Due to the physical properties of protons, proton therapy has tremendous potential to reduce the radiation dose to the healthy, tumour-surrounding tissues. In turn, this leads to less radiation-induced complications, and a decrease in the formation of …

  • 26 Jan, 2021
  • 3 locations
Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

>Round cell Liposarcoma Schwannoma Sclerosing Epithelioid Fibrosarcoma SDH deficient GIST SMARCB1 deficient tumors SMARCA4 deficient tumors

solid tumor
cns tumor
  • 08 Apr, 2021
  • 1 location
MR Fingerprinting for Vestibular Schwannomas

MR Fingerprinting (MRF) will be performed in patients who will be treated with Gamma Knife radio surgery for a vestibular schwannoma before the intervention. Fifty patients will be included with

  • 29 Apr, 2021
  • 1 location