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Found 23 clinical trials
Longitudinal Recovery of Laboratory Clinical and Community-Based Measures of Head and Trunk Control in People With Acquired Vestibulopathy

rehabilitation on laboratory, clinical, and community-based outcomes in people following surgical removal of a schwannoma from the inner-ear nerve.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Innovative Trial for Understanding the Impact of Targeted Therapies in NF2

This is a multi-arm phase II platform-basket screening study designed to test multiple experimental therapies simultaneously in patients with neurofibromatosis type 2 (NF2) with associated progressive tumors of vestibular schwannomas (VS), non-vestibular schwannomas (non-VS), meningiomas, and ependymomas. This Master Study is being conducted as a "basket" study that may allow …

nf2 gene
schwannoma
neurofibromatosis type 2
investigational drug
acoustic neuroma
  • 7 views
  • 06 May, 2021
  • 4 locations
Phase 2 Clinical Trial of Crizotinib for Children and Adults With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas

Subjects with Neurofibromatosis Type 2 (NF2) and progressive vestibular schwannoma (VS) will be treated with crizotinib administered orally. Crizotinib will be taken continuously until disease

MRI Scan
neurofibromatosis type 2
measurable disease
schwartz
absolute neutrophil count
  • 0 views
  • 10 Feb, 2021
  • 14 locations
Immunotherapy Based on Antigen-specific Immune Effector Cells Targeting Neurofibromatosis or Schwannomatosis

immune modified dendritic cell vaccine (DCvac) in the treatment of neurofibromatosis or schwannoma.

bone marrow procedure
primary cancer
neutrophil count
gilbert's syndrome
  • 22 views
  • 25 Jan, 2021
  • 2 locations
Use of Non-invasive Optical Analysis in Neurosurgery

The present study aims to investigate the potential application of multispectral analysis, hyperspectral imaging, and fluorescence during neuro-oncological procedures, specifically during brain tumour debulking / resection. These optics techniques are entirely non-invasive and consist in camera with a filter to be linked to the standard microsurgical and endoscopic instruments used …

  • 0 views
  • 02 Sep, 2021
  • 1 location
Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors

In this research study the researchers want to learn more about the effects (both good and bad) the study drug selumetinib has on participants with neurofibromatosis type II (NF2) related tumor. The researchers are asking patients with NF2 related tumors to be in the study, because their hearing has decreased …

corticosteroids
neurofibromatosis type 2
monoclonal antibodies
MRI
anticonvulsants
  • 582 views
  • 28 Jul, 2021
  • 1 location
Hypofractionated Proton Therapy for Benign Intracranial Brain Tumors the HiPPI Study

This phase II trial studies how well hypofractionated proton or photon radiation therapy works in treating patients with brain tumors. Hypofractionated radiation therapy delivers higher doses of radiation therapy over a shorter period of time and may kill more tumor cells. A shorter duration of radiation treatment may avoid some …

tumor cells
meningioma
pituitary
  • 0 views
  • 02 Jun, 2021
  • 1 location
Study of Viral Transduction of Human Auditory Sensory Cells for the Development of Gene Therapy

> This study aims to study in vitro viral transduction of AAV in human inner ear cells, collected during non-conservative surgeries for vestibular schwannoma.

gene therapy
deafness
viral vector
  • 69 views
  • 26 Jan, 2021
  • 5 locations
Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology

The first proton therapy treatments in the Netherlands have taken place in 2018. Due to the physical properties of protons, proton therapy has tremendous potential to reduce the radiation dose to the healthy, tumour-surrounding tissues. In turn, this leads to less radiation-induced complications, and a decrease in the formation of …

  • 0 views
  • 26 Jan, 2021
  • 3 locations
Natural History and Biospecimen Acquisition for Children and Adults With Rare Solid Tumors

>Round cell Liposarcoma Schwannoma Sclerosing Epithelioid Fibrosarcoma SDH deficient GIST SMARCB1 deficient tumors SMARCA4 deficient tumors

cancer
cns tumor
solid tumor
  • 0 views
  • 15 Sep, 2021
  • 1 location