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Found 401 clinical trials
Evaluation of the Treatment Approach ROBIN

The prevention of schizophrenia and other psychotic disorders has led researchers to focus on early identification of individuals at Clinical High Risk (CHR) for psychosis and to treat the at

  • 0 views
  • 22 Jan, 2021
  • 1 location
Intranasal Insulin and Olanzapine Study in Healthy Volunteers (INI/OLA)

Antipsychotic (AP) medications are considered to be the gold standard treatment for psychotic disorders including schizophrenia. However, APs have also been commonly associated with serious

Accepts healthy volunteers
  • 379 views
  • 23 Feb, 2022
  • 1 location
Understanding of Psychotic Disorders in Children With 22q11.2DS (PremiCeS22)

The study PremiCeS22 will investigate the prodromal signals at the onset of psychotic disorders of children with 22q11.2 deletion syndrome

Accepts healthy volunteers
  • 0 views
  • 23 Mar, 2022
  • 1 location
Development of a Novel Transdiagnostic Intervention for Anhedonia - R33 Phase

The overall goal of this project is to develop a novel transdiagnostic treatment for anhedonia, called Behavioral Activation Treatment for Anhedonia (BATA), using ultra-high field functional neuroimaging. There is a critical need for a validated treatment that specifically targets anhedonia, and this project will evaluate the effects of this new …

  • 10 views
  • 14 Feb, 2022
  • 1 location
Effects of Cannabidiol (CBD) Versus Placebo as an Adjunct to Treatment in Early Psychosis

This is an outpatient, single center, between-group, double blind, placebo controlled design. Approximately 120 adolescents and adult patients will be randomized to either have their treatment augmented with Cannabidiol Oral Solution (CBD) or with a matching CBD placebo for 8 weeks. The study will examine CBD as an augmentation strategy …

  • 0 views
  • 22 Jun, 2021
  • 2 locations
Using Telehealth to Improve Outcomes in Veterans at Risk for Suicide

Overview. The investigators will randomize 120 Veterans in this 3-site trial over 16 months. Eligible Veterans will include those to be discharged for a hospitalization for suicidal ideation. Baseline data collection and randomization will occur at discharge. The 3 month intervention will have study assessments at 2, 4, 8, and …

depressive symptoms
depressed mood
depression
  • 0 views
  • 18 May, 2022
  • 2 locations
Opioid Based Analgesia vs Non-opioid Analgesia for Oocyte Retrieval Procedure

It is unclear whether routine addition of opioids for analgesia during minor gynecological procedures is beneficial. In this single-center randomized single-blinded trial, the investigators aim to test the primary hypothesis that opioid-sparing anesthesia regimen including intravenous acetaminophen is non-inferior to a similar anesthesia regimen containing fentanyl in providing postoperative analgesia …

  • 0 views
  • 17 Dec, 2021
  • 1 location
Glutamatergic Mechanisms of Psychosis and Target Engagement (SA1)

50 healthy volunteers (HV) will participate in 2 identical ketamine-induced pharmacoBOLD (phBOLD) sessions at least 7 days apart. On both days, clinical assessments will be performed following removal of the subject from the scanner. HV will be discharged home after clearance by the study physician. This study will assign ketamine …

Accepts healthy volunteers
  • 96 views
  • 22 Mar, 2022
  • 1 location
Adapting a Digital Intervention to Improve Smoking Cessation in Persons With Serious Mental Illness

All patients with serious mental illness are abstinent while in the hospital for a psychiatric admission yet almost all return to smoking after discharge. The investigators propose to adapt a digital intervention both to the needs of SMI smokers and to being introduced in the inpatient psychiatric setting through a …

  • 0 views
  • 29 May, 2022
  • 1 location
A Brief Emotion Focused Therapy for Preschoolers With Anxiety Disorders

The study will comprise of three groups of children (n=40): 1. A group receiving a novel short-term dynamic play therapy. 2. Dyadic therapy 3. Control group who will not receive therapy. All children will be assessed for psychopathology (anxiety, depression and behavioral problems) using standardized instruments such as semi-structured interview …

  • 0 views
  • 10 Aug, 2021
  • 1 location