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Found 401 clinical trials
Retinoic Acid Homeostasis in Neuropsychiatric Diseases (RAHND)

status will be assessed in healthy controls and subjects with Major Depression, Alzheimer's disease, alcoholism and in subjects with schizophrenia.

alcoholism
depressive episode
depression
schizophrenia
alzheimer's disease
  • 29 views
  • 24 Jan, 2022
  • 1 location
SV2 PET Imaging With [11C]APP311 (SV2)

The aim of this study is to evaluate a new SV2A tracer, [11C]APP311, in healthy aging and neuropsychiatric disorders including psychotic disorders and cannabis use disorders.

Accepts healthy volunteers
  • 0 views
  • 25 Mar, 2022
  • 1 location
Dundrum Forensic Redevelopment Evaluation Study: D-FOREST Study.

The DUNDRUM Forensic Redevelopment Evaluation study (D-FOREST study) is a multi-site comprehensive evaluation of a complete National Forensic Mental Health Service. The study will have a prospective, observational, longitudinal design which will permit the evaluation of benefit over time for individual patients, groups of patients and the evaluation of the …

  • 0 views
  • 20 Oct, 2021
  • 1 location
Semantic and Syntactic Computerized Analysis of Free Speech (ASESID)

Subtle speech disorganization could be predictive of a transition to schizophrenia of ultra-high-risk patients. The aim of our longitudinal multicenter cohort study is to identify specific

psychosis
antipsychotics
suicidal
schizophrenia
  • 695 views
  • 16 Jun, 2022
  • 2 locations
Striatal Connectivity and Clinical Outcome in Psychosis

risperidone or aripiprazole. Patients who present for treatment of a first psychotic episode with a schizophrenia spectrum diagnosis and who are eligible to undergo treatment with either risperidone or

structured clinical interview
scid
antipsychotics
schizoaffective disorder
schizophrenia
  • 64 views
  • 25 Mar, 2022
  • 1 location
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty

, schizophrenia, and substance abuse. Many of these sex differences emerge during or shortly after puberty and are maintained until the 5th-6th decade of life. For example, the two-fold greater risk of unipolar

Accepts healthy volunteers
  • 7 views
  • 15 Jun, 2022
  • 1 location
The Gut Microbiota of Bipolar and Depression

Background: The gut microbiome is emerging as an important factor in regulating mental health yet it remains unclear what the target should be for psychiatric treatment. Investigators aim at elucidating the complement of the gut microbiome community for individuals with Major Depressive disorder (MDD) and Bipolar disorder (BD) relative to …

Accepts healthy volunteers
psychiatric treatment
depressed mood
depression
bipolar disorder
  • 283 views
  • 25 Feb, 2022
  • 1 location
Trajectories of Treatment Response as Window Into the Heterogeneity of Psychosis: a Longitudinal Multimodal Imaging Study

Psychosis is a heterogeneous disorder and present treatment only works for a limited number of patients. In order to identify new therapeutic targets, this study will longitudinally characterize the underlying pathologies in those with poor treatment response using complimentary brain imaging modalities.

aripiprazole
antipsychotics
risperidone
  • 105 views
  • 26 Feb, 2022
  • 1 location
Neural Correlates of Sensory Phenomena in Tourette Syndrome

The primary aim of this study is to identify neural correlates of sensory phenomena in adults with Tourette syndrome (TS). Adult patients with TS will be recruited 1) to complete a standardized clinical symptom assessment battery and 2) to undergo monitoring with video-electroencephalogram (EEG) during tactile and auditory tasks, as …

Accepts healthy volunteers
tourette's syndrome
  • 402 views
  • 26 May, 2022
  • 1 location
Comparative Tobacco Interventions for Individuals With Severe and Persisting Behavioral Health Disorders

The aim of this pilot intervention is to examine the acceptability of a harm reduction intervention approach to tobacco use for individuals with serious behavioral health disorders and its association with a decrease in smoking. The intervention uses a "dynamic" approach to patient choice, allowing participants the option to explore …

anxiety
nicotine dependence
substance use
nicotine product
  • 10 views
  • 04 Oct, 2021
  • 1 location