Found 285 clinical trials
Biomarkers of Conversion Risk and Treatment Response in Early-Stage Schizophrenia
Schizophrenia (SZ) is a highly debilitating neuropsychiatric disorder of young adulthood onset and a leading cause of disability worldwide. While treatments delivered at early stages of the
- 7 views
- 04 Oct, 2022
- 1 location
A Randomized Controlled Trial With Rituximab - for Schizophrenia Spectrum Disorder in Adults (RCT-RITS2022)
randomised placebo-controlled double-blinded, add-on treatment trial in 104 participants (18-51 years) with schizophrenia spectrum disorder. Sampling from blood for analyses of inflammatory mediators are
- 0 views
- 04 Apr, 2023
- 1 location
A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia
This study will test whether CVL-562 (PF-06412562), a dopamine 1 partial agonist novel compound, affects working memory neural circuits in patients with early episode schizophrenia. The overall
- 24 views
- 04 Oct, 2022
- 4 locations
Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of First Rank Symptoms on Schizophrenia: Controlled, Randomised, Double Blind Trial (Schirang)
First rank symptoms are core symptoms of schizophrenia. the investigators want to offer an integrative approach to better understanding of the mechanisms involved in the first rank symptoms and
- 12 views
- 23 Oct, 2022
- 1 location
An Adaptive Phase II/III, Two-Part, Double-Blind, Randomized, Placebo-controlled, Dose-Finding, Multi-center Study of the Safety and Efficacy of NaBen®, as an Add-on Therapy With Clozapine, for Residual Symptoms of Refractory Schizophrenia in Adults
refractory schizophrenia. Part 1 Objectives: There are two primary objectives for Part 1 of this study: To evaluate, in terms of dose-response, the effectiveness of NaBen (1000 and 2000
- 55 views
- 24 Feb, 2022
- 1 location
Individualized Repetitive Transcranial Magnetic Stimulation for Auditory Verbal Hallucinations
proposed as a novel treatment for people with schizophrenia. The investigators want to see if low frequency rTMS can lessen some of the symptoms of schizophrenia, specifically auditory verbal
- 0 views
- 04 Oct, 2022
- 1 location
Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)
To compare two evidence-based treatments, Cognitive Enhancement Therapy (CET) and Social Skills Training (SST) that have been shown in meta-analyses and in our own research to be effective to improve community functioning. The investigators will test the impact of CET and SST on community functioning, with special attention to their …
- 0 views
- 19 Apr, 2022
- 4 locations
An Open-label Extension Trial of Individualized Repetitive Transcranial Magnetic Stimulation in Patients With Auditory Verbal Hallucinations Who Completed Protocol #8116
This is an open-label extension study to continue to evaluate the safety, tolerability and efficacy of the Repetitive Transcranial Magnetic Stimulation (rTMS) in subjects with schizophrenia or
- 0 views
- 12 Oct, 2022
- 1 location
Plan D- Vitamin D Supplementation in Psychotic Disorders
Background: Impairment in cognitive processing speed is a consistent finding in schizophrenia spectrum disorder. Vitamin D deficiency is found to be significantly associated with reduced
- 0 views
- 26 Apr, 2022
- 1 location
Acceptance and Commitment Therapy-based Lifestyle Counselling Programme for Early Psychosis on Physical Activity
This pilot randomized controlled trial aims to determine the feasibility, acceptability and preliminary effects of an Acceptance and Commitment Therapy-based Lifestyle Counselling Programme (ACT-LCP) on the physical and psychosocial health outcomes of patients with early psychosis over a 12-week follow-up.
- 21 views
- 07 Oct, 2022
- 1 location