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Found 19 clinical trials
Featured trial
Novel Multimodal Assessment of Practical Judgment Across the Alzheimer's Continuum: Toward a Better Understanding of how to Predict Risk in the Elderly

By the year 2050, as many as 16 million individuals in the U.S. will express symptoms of Alzheimer’s disease (AD). A recent White House Conference on Aging emphasized the need to improve detection of diminished capacity as a means to improve personal safety and prevent financial exploitation and abuse. The …

alzheimer's disease
Accepts healthy volunteers
  • 25 Jul, 2022
  • 1 location
Immune Cells During Disuse and Recovery

This is an interventional study enrolling healthy individuals aged 18-35 and 60-85 to understand the recovery of muscle health following a period of inactivity. The enrollment goal is 45 participants. The study will occur over the course of 1-2 months where participants will undergo testing before and after a 2-week …

Accepts healthy volunteers
  • 14 Jul, 2022
  • 1 location
Mechanisms of Change in Cognitive Behavioral Therapy for Insomnia (CBTi) (CBTi)

The purpose of this study is to investigate the mechanisms of change in Cognitive Behavioral Therapy for insomnia (CBTi) in a sample of adults aged 50-65. This study aims to evaluate the pre-post treatment change in sleep, circadian rhythms, biomarkers, cognitive performance, and structural and functional magnetic resonance imaging scans …

behavior therapy
cognitive behavioral therapy for insomnia
  • 14 Mar, 2022
  • 1 location
A Prospective Pilot Study Investigating rhPSMA 7.3 PET/MRI in Detecting Recurrent Disease and Aid in Radiotherapy Planning in Patients With Biochemically Recurrent Prostate Cancer

where the cancer may be or how much cancer there may be. Imaging tests, like a bone scan, MRI, and/or computed tomography, are often performed to help the doctor learn where or how much cancer there is

  • 27 Oct, 2022
  • 1 location
A Phase II Trial of Neoadjuvant Laparoscopic Hyperthermic Intraperitoneal Chemotherapy (HIPEC) With Chemoradiation

involves CT scan/ MRI combined with endoscopic US for more accurate T, N staging. Once the patient is deemed to have locally advanced gastric cancer (T3/T4,N0/+), a staging laparoscopy is recommended to

endoscopic ultrasound
gastric adenocarcinoma
neutrophil count
adjuvant therapy
  • 02 Mar, 2022
  • 3 locations
Studies in Patients With Defecatory Disorders

out intraluminal organic cause for patients' symptoms, endoanal ultrasound scan / MRI to assess patients' pelvic floor anatomy and anorectal manometry and balloon expulsion test to assess anorectal

chronic constipation
anal canal
anorectal manometry
  • 13 Mar, 2021
  • 2 locations
A Phase I Trial of T Cell Receptor Gene Therapy Targeting KK-LC-1 for Gastric, Breast, Cervical, Lung and Other KK-LC-1 Positive Epithelial Cancers

participants will come to the NIH campus to have a screening evaluation which will include physical exam, review of medical history and current medications, blood and heart tests, imaging (X-ray, CT scan, MRI

  • 20 Oct, 2022
  • 1 location
TAGGED: A Phase 2 Study Using Low Dose/Metronomic Trabectedin, Gemcitabine, and Dacarbazine as 2nd/3rd/4th Line Therapy for Advanced Leiomyosarcoma (TAGGED)

This is an open label phase 2 study using metronomic doses of trabectedin, gemcitabine and dacarbazine given intravenously.

platelet count
kidney function tests
  • 23 Oct, 2022
  • 1 location
Retina is a Marker for Cerebrovascular Heath

Cerebral small vessel disease (SVD), present in 80-94% of adults over age 65 years, increases the risk of stroke by 2-fold, and dementia by 2.3-fold. There is currently no treatment to slow SVD progression. This study aims to test whether impaired cerebral and retinal vasoreactivity may serve as biomarker for …

Accepts healthy volunteers
  • 04 Oct, 2022
  • 1 location
A Phase II Study of Cyberknife Radiosurgery for Renal Cell Carcinoma

CyberKnife Based Radiosurgery is a way to deliver large doses of radiation very accurately to a tumor. The ability of this technology to minimize radiation dose to organs adjacent to the target tumor allows a high dose to be delivered to the tumor, thus potentially increasing the efficacy of radiation …

lung cancer
brain metastasis
ct scan
  • 01 May, 2022