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Found 8 clinical trials
The Influence of Telerehabilitation Focused on Respiratory Muscle Training

Pulmonary rehabilitation, which includes respiratory muscle training, is effective in improving the functional status of patients with various types of the respiratory system diseases, including bronchial asthma, interstitial lung diseases or lung transplant patients. However, availability of pulmonary rehabilitation is limited in the Czech Republic. Nowadays even more due to …

  • 07 Oct, 2022
  • 1 location
A Study to Assess the Efficacy and Safety of Namilumab in Participants With Chronic Pulmonary Sarcoidosis (RESOLVE-Lung)

This is a randomized, double-blind, placebo-controlled study with an open-label extension (OLE).

  • 07 Apr, 2023
  • 11 locations
A Subject and Investigator Blinded, Randomized, Placebo-controlled, Repeat-dose, Multicenter Study to Investigate Efficacy, Safety, and Tolerability of CMK389 in Patients With Chronic Pulmonary Sarcoidosis

The purpose of this proof of concept study is to determine whether CMK389 displays the safety and efficacy profile to support further development in chronic pulmonary sarcoidosis.

pulmonary sarcoidosis
  • 13 Oct, 2022
  • 27 locations
Effectiveness of Methotrexate Versus Prednisolone as First-line Therapy for Pulmonary Sarcoidosis

This is a prospective, randomized, non-blinded, multi-center, non-inferiority trial designed to compare effectiveness and side-effects of methotrexate versus prednisolone as first-line therapy for pulmonary sarcoidosis..

  • 30 Aug, 2021
  • 18 locations
Efficacy and Safety of Intravenous Efzofitimod in Patients With Pulmonary Sarcoidosis

This is a multicenter, randomized, double-blind, placebo-controlled, study comparing the efficacy and safety of intravenous (IV) efzofitimod 3 mg/kg and 5 mg/kg versus placebo after 48 weeks of treatment. This study will enroll adults with histologically confirmed pulmonary sarcoidosis receiving stable treatment with oral corticosteroid (OCS), with or without immunosuppressant …

pulmonary sarcoidosis
  • 07 Oct, 2022
  • 6 locations
Role of Genetic Factors in the Development of Lung Disease

This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease. The study will focus on defining the distribution of abnormal genes responsible for processes …

chest ct
genetic disorder
MRI Scan
cftr gene
  • 11 Apr, 2023
  • 1 location
Development of Clinical Prediction Models for Pulmonary Outcomes in Sarcoidosis (RISE-UP)

The purpose of this study is to develop prediction models that can prognosticate patients with sarcoidosis using clinical data and blood markers that can be obtained during a clinic visit.

  • 28 Oct, 2022
  • 2 locations
Epigenetic Regulation of Altered T-cell Immunity in Sarcoidosis

Sarcoidosis is a multi-system granulomatous disorder that is triggered and influenced by gene-environment interactions. Although sarcoidosis predominantly affects the lungs in most cases, the clinical disease course is highly variable and any organ can be affected leading to end organ damage despite currently available therapeutics that unfortunately also have numerous …

granulomatous disease
  • 23 Feb, 2022
  • 1 location