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Found 95 clinical trials
Ruxolitinib Pre- During- and Post-HSCT for Patients With Primary or Secondary Myelofibrosis.

This research study is studying a drug called Ruxolitinib as a possible treatment for Myelofibrosis.

myeloproliferative disorder
ruxolitinib
stem cell transplantation
secondary myelofibrosis
platelet count
  • 78 views
  • 26 Jan, 2021
  • 5 locations
Ruxolitinib for Bronchiolitis Obliterans Syndrome (BOS) After Allogeneic Hematopoietic Cell Transplantation (HCT)

This research study is studying a drug as a possible treatment for Bronchiolitis Obliterans Syndrome (BOS) after having an Allogeneic Hematopoietic Cell Transplantation (HCT).

  • 1 views
  • 26 Jan, 2021
Ruxolitinib for the Treatment of Chronic Myelomonocytic Leukemia (CMML): A Phase 2 Expansion

This study is to find out if treating Chronic Myelomonocytic Leukemia (CMML) with a study drug (ruxolitinib) can improve outcomes of patients with CMML.

chronic myelomonocytic leukemia
myeloproliferative disorder
  • 4 views
  • 22 Aug, 2021
  • 4 locations
Treatment Free Remission After Combination Therapy With Ruxolitinib Plus Tyrosine Kinase Inhibitors

The purpose of this study is to determine if adding Ruxolitinib to a Tyrone Kinase Inhibitor (TKI), prior to a second attempt at stopping a TKI will lead to prolonged treatment free remission

  • 0 views
  • 24 Jun, 2021
  • 9 locations
Ruxolitinib and Venetoclax in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

This phase I trial studies the side effects and best dose of ruxolitinib when given together with venetoclax in treating patients with acute myeloid leukemia that has come back (relapsed) or has

hydroxyurea
myeloid leukemia
refractory acute myeloid leukemia (aml)
ruxolitinib
cancer
  • 3 views
  • 15 Sep, 2021
  • 4 locations
Pembrolizumab and Ruxolitinib Phosphate in Treating Patients With Metastatic Stage IV Triple Negative Breast Cancer

This phase I trial studies the side effects and best dose of ruxolitinib phosphate when given together with pembrolizumab in treating patients with stage IV triple negative breast cancer that

metastasis
cancer
monoclonal antibody therapy
epidermal growth factor receptor
monoclonal antibodies
  • 42 views
  • 05 Jun, 2021
  • 1 location
Ruxolitinib and Pomalidomide Combination Therapy in Patients With Primary and Secondary MF

The proposed study is an open-label, single-arm, Phase-Ib/II trial to assess the efficacy of oral drug combination ruxolitinib and pomalidomide in primary and secondary MF patients.

polycythemia
myeloproliferative neoplasm
myeloproliferative disorder
anemia
secondary myelofibrosis
  • 38 views
  • 23 Jan, 2021
  • 27 locations
Multi-Ctr PII Cmb.Modality Tx Ruxolitinib Decitabine and DLI for Post HSCT in AML/MDS

This is a multi-center, single-arm, open-label, phase II trial for the frontline treatment of relapsed AML or MDS following allo-HCT. Eligible subjects will receive up to 4 cycles of combined modality treatment. The number of cycles depends on response, toxicity, and the remaining cell dose.

aml/mds
blast cells
donor lymphocyte infusion
hydroxyurea
colony stimulating factor
  • 0 views
  • 03 Feb, 2021
  • 3 locations
Study of Trametinib and Ruxolitinib in Colorectal Cancer and Pancreatic Adenocarcinoma

The purpose of this research study to find out if the drug trametinib in combination with ruxolitinib is safe, tolerable and has beneficial effects in people who has certain type of cancers

adenocarcinoma
tyrosine
measurable disease
systemic therapy
liver metastasis
  • 5 views
  • 01 Jun, 2021
  • 1 location
Ruxolitinib and Chemotherapy in Adolescents and Young Adults With Ph-like Acute Lymphoblastic Leukemia

This study will test if adding ruxolitinib to standard multi-drug chemotherapy regimen will be safe and tolerated in adolescents and young adults with newly diagnosed Ph-like acute lymphoblastic

dexamethasone
corticosteroids
pegaspargase
blast crisis
cytarabine
  • 0 views
  • 25 Jan, 2021
  • 1 location