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Found 95 clinical trials
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Intra-patient Dose Escalation Study to Investigate Safety and Feasibility of Vactosertib in Treating Anemic MPN Patients

This study assesses the potential of using a TGF receptor inhibitor for the treatment of anemic patients with myeloproliferetive neoplasms. TGF signaling is known to be abnormally high in patients with myeloproliferative neoplasms and it is thought that abnormal TGF signals cause many of the problems with blood cell formation …

anemia
myelodysplastic/myeloproliferative neoplasm
hydroxyurea
ruxolitinib
  • 0 views
  • 28 Jan, 2021
  • 1 location
None
Allogeneic Hematopoietic Cell Transplantation for Peripheral T Cell Lymphoma

Background Lymphoma is a type of blood cancer. Blood cell transplant can cure some people with lymphoma. Researchers want to see if they can limit the complications transplant can cause. Objective To test if a stem cell transplant can cure or control lymphoma. Also to test if new ways of …

apheresis
estimated creatinine clearance
pulmonary function tests
ejection fraction
blood transfusion
  • 3 views
  • 28 Oct, 2021
  • 2 locations
None
Ruxolitinib in Myelofibrosis Patients in Lombardy Italy

ruxolitinib in a "real world" setting. Patients are treated according to current indications in Italy (i.e., primary and secondary MF patients with intermediate-1, intermediate-2, and high risk IPSS

thrombocytosis
cancer
stem cell transplantation
essential thrombocythemia
polycythemia
  • 50 views
  • 22 Jan, 2021
  • 7 locations
None
Systemic Sclerosis and Jak Inhibitors : Emphasis on Macrophages

The Sclero-JAK project aims to assess the impact of a JAK1/2 inhibitor (ruxolitinib) on activation states of monocytes-derived macrophages (MDM) from systemic sclerosis (SSc) patients

  • 0 views
  • 26 Mar, 2021
  • 1 location
None
Study of Stem Cell Transplant vs. Non-Transplant Therapies in High-Risk Myelofibrosis

The purpose of this research study is to see how effective hematopoietic stem cell transplantation (HCT) is compared to best available non-transplant therapies (BAT) in patients with high risk myelofibrosis. This will be done by asking participants to choose the treatment that they prefer to receive (HCT or BAT) and …

thrombocytosis
hydroxyurea
cancer
stem cell transplantation
essential thrombocythemia
  • 0 views
  • 24 Feb, 2021
  • 6 locations