Found 64 clinical trials
Empagliflozin for the Treatment of Postprandial Hypoglycemia
This randomized trial is to test whether a treatment with empagliflozin is superior to placebo in patients with postprandial hypoglycemia after bariatric surgery, that is if it improves health related quality of life (mentally or physically) or reduces the risk of hypoglycemic events.
- 0 views
- 26 Nov, 2021
- 3 locations
Comparing 150cm OAGB With 150cm Biliopancreatic Limb RYGB. A Non-inferiority Trial (Roux-en-WHY?)
The purpose of this study is to assess the safety and efficiency of OAGB compared to RYGB
- 0 views
- 21 Mar, 2022
- 1 location
Surgical or Medical Treatment (ST2OMP)
This study will test the hypothesis that metabolic bariatric surgery will be more effective at providing durable glycemic control and reduce co-morbidities than intensive medical therapy in youth with type 2 diabetes.
- 22 views
- 04 Oct, 2022
- 2 locations
Cerebrospinal Fluid Biomarkers in Bariatric Surgery
The goal of this project is to understand why bariatric surgery is such an effective treatment for obesity with a focus on brain mechanisms. Cerebrospinal fluid (CSF) neuropeptide, hormone and protein levels will be measured as a surrogate for changes in brain activity in participants before and after bariatric surgery …
- 0 views
- 14 Apr, 2022
Metabolic and Endocrine Effects of Bariatric Surgery
The purpose of this study is to determine if diet-induced weight loss causes different changes in hormones that control appetite and glucose control than surgery-induced weight loss. The overall research plan is a non-randomized prospective study of 3 different weight loss (WL) interventions and a lean and an obese healthy …
- 243 views
- 22 Oct, 2022
- 1 location
Pharmacokinetics of Simvastatin Post Laparoscopic Sleeve Gastrectomy (LSG)
This study aims to investigate the change in systemic exposure of simvastatin post LSG.
- 0 views
- 24 Apr, 2022
- 1 location
The Importance of Ghrelin for Glucose Metabolism After Sleeve Gastrectomy
The overall aim is to delineate the contribution of ghrelin to glucose tolerance after sleeve gastrectomy. The hypothesis is that decreased concentration of ghrelin after SG is of importance for improved insulin secretion and glucose tolerance seen after SG. The expectation is therefore that infusion of ghrelin will impair insulin …
- 0 views
- 25 Mar, 2022
The Effect of Probiotics on Systemic Inflammation and Metabolic Endotoxemia in Patients Undergoing Bariatric Surgery
This study explores the effects of probiotic administration on the outcomes of surgical treatment, and also on the state of the intestinal microbiota and the intestinal barrier. The study protocol is designed as a randomized double-blind placebo-controlled clinical trial. Patients qualified for bariatric surgery will be randomized to receive probiotics …
- 0 views
- 17 Jun, 2022
- 1 location
Prospective Randomized Study Comparing Three Hypoabsortive Techniques for the Treatment of Type IV Obesity: Double-anastomosis Duodenal Switch (DS), Single- Anastomosis Duodenal Switch SADI-S) and One Anastomosis Gastric By-pass (OAGBP) (BAR-3)
Morbid obesity is the first non-traumatic cause of death in the western population and it is also progressively beginning to affect the developing countries. Bariatric surgery provides better results than pharmacological treatments and lifestyle changes, granting a better control of comorbidities. Duodenal switch (DS) has proben to be the most …
- 0 views
- 18 Oct, 2022
- 1 location
Extending Time Without Diabetes After Bariatric Surgery: a Trial Comparing the Metformin Addition or Not to Standard Care (DiabOUT)
This study is a randomized trial that evaluates the effect of metformin addition or not to standard care on the duration of diabetes remission after bariatric surgery.
- 0 views
- 27 May, 2022
- 12 locations