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Found 16 clinical trials
Phase 2 Study for SAR443820 in Participants With Amyotrophic Lateral Sclerosis (ALS) (HIMALAYA)

, region of ALS onset (bulbar vs other areas), use of riluzole (yes vs no), and use of edaravone (yes vs no). Participants will attend inclinic study assessments at baseline (Day 1), Week 2, Week 4, Week

primary lateral sclerosis
body mass index
edaravone
riluzole
  • 0 views
  • 24 May, 2022
  • 9 locations
Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS (TUDCA-ALS)

This is a Phase III, multi-centre, randomized, double-blind, placebo-controlled, parallel-group study to evaluate Safety and Efficacy of Tauroursodeoxycholic (TUDCA) as add-on Treatment in Patients Affected by Amyotrophic Lateral Sclerosis (ALS).

primary lateral sclerosis
riluzole
pulmonary function test
dysphagia
  • 278 views
  • 03 Feb, 2022
  • 24 locations
A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS) (COURAGE-ALS)

The purpose of this study is to assess the effect of reldesemtiv versus placebo on functional outcomes in ALS.

primary lateral sclerosis
weakness
edaravone
riluzole
  • 0 views
  • 12 May, 2022
  • 55 locations
Effectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy.

It is a phase II trial, randomized, parallel, double blind, multicenter, comparing riluzole versus placebo. The trial population is composed of patients 18 years old that have developed

  • 0 views
  • 28 Jun, 2021
  • 16 locations
RiLuzole to Reduce Atrial FIbrillatiON A Prospective, Double-Blind, Randomized, Placebo-Controlled Study Using Holter Monitoring (SOLUTION)

AAD for the control of AF. Recent published translational studies suggest that that neuronal-type Na+ channel blockade (nNav) with riluzole, a nNav inhibitor used to manage amyotrophic lateral

  • 0 views
  • 09 Apr, 2022
  • 1 location
Riluzole in Combination With mFOLFOX6 and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer

This phase I trial is to find out the best dose, possible benefits, and/or side effects of riluzole and how well it works in combination with standard of care mFOLFOX6 and bevacizumab in

  • 0 views
  • 22 Dec, 2021
  • 1 location
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

The objective is to compare the efficacy and safety of masitinib in combination with riluzole versus matched placebo in combination with riluzole for the treatment of Amyotrophic Lateral

  • 0 views
  • 27 Jan, 2021
  • 2 locations
The Treatment of Amyotrophic Lateral Sclerosis With Huollingshengji Granules

comparison with riluzole, so as to provide data support for marketing application or subsequent clinical research design.

primary lateral sclerosis
riluzole
deficit
  • 0 views
  • 18 Jul, 2021
  • 1 location
Analysis of Capillary Retinal and Papillary Vascularization in Patients With Amyotrophic Lateral Sclerosis - CAPISLA

patients are affected in France. The only therapeutic treatment available to date in France is riluzole, which slows the progression of the disease. Amyotrophic Lateral Sclerosis is the first degenerative

primary lateral sclerosis
neurological disorder
riluzole
Accepts healthy volunteers
  • 0 views
  • 14 Oct, 2021
  • 1 location
A Trial of Nicotinamide/Pterostilbene Supplement in ALS: The NO-ALS Extension Study

Amyotrophic lateral sclerosis (ALS) is a serious rapidly progressive disease of the nervous system. The mean survival from the time of diagnosis is 2.5 years. Apart from Riluzole, there is no

primary lateral sclerosis
progressive disease
riluzole
  • 0 views
  • 03 Nov, 2021
  • 17 locations