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Found 17 clinical trials
Featured trial
A Randomized, Double-Blind, Placebo-Controlled Trial of Adjunctive Troriluzole in Obsessive Compulsive Disorder

studies.Troriluzole is thought to work like its main by-product riluzole which has been FDA approved for ALS treatment and tends to block certain mechanisms in the body that cause

  • 4 views
  • 05 Apr, 2021
  • 1 location
None
Olanzapine for the Treatment of Appetite Loss in Amyotrophic Lateral Sclerosis (ALS)

combination with Riluzole (RIL) 100mg is at least 20 percentage points less than for treatment with placebo in combination with 100 mg RIL.

primary lateral sclerosis
atrophy
neurodegenerative disorders
riluzole
  • 42 views
  • 07 Nov, 2020
  • 1 location
None
Cistanche Total Glycosides for Amyotrophic Lateral Sclerosis: A Randomized Control Trial (RCT) Study Assessing Clinical Response

respiratory muscles. Usually death from respiratory failure typically is within 3-5 years of diagnosis. Although there are various treatments for ALS, riluzole is the only approved treatment to

respiratory failure
weakness
riluzole
spinal cord
primary lateral sclerosis
  • 30 views
  • 07 Nov, 2020
  • 1 location
None
Non-Invasive Ventilation in Amyotrophic Lateral Sclerosis

Non-invasive mechanical ventilation (NIV) has been increasingly used as a treatment of chronic hypercapnic respiratory failure. Its use in patients affected by chronic obstructive pulmonary disorders is still controversial, while most of the studies performed in restrictive thoracic disorders (RTD), and in particular in neuromuscular patients, suggested alleviation of the …

respiratory failure
assisted ventilation
maximal inspiratory pressure
non-invasive ventilation
primary lateral sclerosis
  • 49 views
  • 07 Nov, 2020
  • 1 location
None
Safety and Efficacy of TUDCA as add-on Treatment in Patients Affected by ALS

This is a Phase III, multi-centre, randomized, double-blind, placebo-controlled, parallel-group study to evaluate Safety and Efficacy of Tauroursodeoxycholic (TUDCA) as add-on Treatment in Patients Affected by Amyotrophic Lateral Sclerosis (ALS).

primary lateral sclerosis
riluzole
dysphagia
pulmonary function test
  • 140 views
  • 28 Mar, 2021
  • 33 locations
None
A Study to Evaluate the Efficacy and Safety of Reldesemtiv in Patients With Amyotrophic Lateral Sclerosis (ALS)

The purpose of this study is to assess the effect of reldesemtiv versus placebo on functional outcomes in ALS.

primary lateral sclerosis
edaravone
weakness
riluzole
  • 0 views
  • 24 Nov, 2021
  • 17 locations
None
Effectiveness Assessment of Riluzole in the Prevention of Oxaliplatin-induced Peripheral Neuropathy.

It is a phase II trial, randomized, parallel, double blind, multicenter, comparing riluzole versus placebo. The trial population is composed of patients 18 years old that have developed

  • 0 views
  • 28 Jun, 2021
  • 16 locations
None
Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients

The objective is to compare the efficacy and safety of masitinib in combination with riluzole versus matched placebo in combination with riluzole for the treatment of Amyotrophic Lateral

  • 0 views
  • 27 Jan, 2021
  • 2 locations
None
The Treatment of Amyotrophic Lateral Sclerosis With Huollingshengji Granules

comparison with riluzole, so as to provide data support for marketing application or subsequent clinical research design.

deficit
primary lateral sclerosis
riluzole
  • 0 views
  • 18 Jul, 2021
  • 1 location
None
Analysis of Capillary Retinal and Papillary Vascularization in Patients With Amyotrophic Lateral Sclerosis - CAPISLA

patients are affected in France. The only therapeutic treatment available to date in France is riluzole, which slows the progression of the disease. Amyotrophic Lateral Sclerosis is the first degenerative

primary lateral sclerosis
neurological disorder
Accepts healthy volunteers
riluzole
  • 0 views
  • 14 Oct, 2021
  • 1 location