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Found 10 clinical trials
A Roll-over Study With Rilpivirine for Human Immunodeficiency Virus Type 1 (HIV-1) Infected Participants Who Participated in Rilpivirine Pediatric Studies

The purpose of this study is to provide continued access to rilpivirine (RPV) for participants who were treated with RPV in a clinical development pediatric study with rilpivirine and who, at

  • 0 views
  • 22 Apr, 2021
  • 13 locations
A Study Evaluating Implementation Strategies for Cabotegravir (CAB)+ Rilpivirine (RPV) Long-acting (LA) Injectables for Human Immunodeficiency Virus (HIV)-1 Treatment in European Countries

The overall objective of the CAB LA + RPV LA clinical development program is to develop a highly effective, well-tolerated, two-drug, LA injectable regimen which has the potential to offer improved treatment convenience, compliance and improved quality of life for people living with HIV compared to current standard of care. …

local anesthetic
antiretroviral therapy
hysterectomy
antiretroviral
hiv-1 rna measurement
  • 0 views
  • 18 Apr, 2021
  • 15 locations
A Study of Switching to RPV Plus Other ARVs in HIV-1-infected Children (Aged 2 to <12 Years) Who Are Virologically Suppressed

The purpose of this study is to evaluate the steady state pharmacokinetics (PK) of rilpivirine (RPV) and determine the appropriate dose of RPV in combination with other antiretrovirals (ARVs) in

lamivudine
rilpivirine
immunodeficiency
dolutegravir
emtricitabine
  • 53 views
  • 21 Apr, 2021
  • 19 locations
A Study to Evaluate Efficacy and Safety of Cabotegravir (CAB) Long Acting (LA) Plus (+) Rilpivirine (RPV) LA Versus BIKTARVY (BIK) in Participants With Human Immunodeficiency Virus (HIV)-1 Who Are Virologically Suppressed

Human immunodeficiency virus (HIV)/Acquired Immunodeficiency Syndrome (AIDS) is a worldwide epidemic that continues to grow significantly causing new infections and related deaths per year. Chronic HIV infection in adults continues to be characterized by increased development and transmission of resistant virus and issues associated with long-term toxicity of antiretroviral therapy …

  • 0 views
  • 14 May, 2021
  • 95 locations
A Study to Evaluate the Pharmacokinetics Safety Tolerability and Antiviral Activity of Rilpivirine (TMC278) in Human Immunodeficiency Virus Infected Adolescents and Children Aged Greater Than or Equal to 6 Years

The purpose of this study is to evaluate the pharmacokinetics, safety and antiviral activity of rilpivirine (TMC278) 25 milligram (mg) or adjusted dose once daily in combination with an

  • 169 views
  • 28 Jan, 2021
  • 25 locations
The LATITUDE Study: Long-Acting Therapy to Improve Treatment SUccess in Daily LifE

The purpose of this study is to compare the efficacy, safety, and durability of two different strategies to treat participants with a history of sub-optimal adherence and control of their HIV infection: long-acting (LA) antiretroviral therapy (ART) and all-oral standard of care (SOC).

local anesthetic
antiretroviral therapy
hiv test
hysterectomy
antiretroviral
  • 242 views
  • 01 May, 2021
  • 33 locations
Antiretroviral Pregnancy Registry (APR): Multi-sponsor Registry to Detect Any Major Teratogenic Effect Involving Any of the Registry Drugs When Administered to Pregnant Women.

The purpose of the Antiretroviral Pregnancy Registry (Registry) is to detect any major teratogenic effect involving any of the Registry drugs when administered to pregnant women. Registration is voluntary and confidential with information obtained from the health care provider. A Registry-assigned identifier allows for follow-up capability. Information on subjects is …

hepatitis
antiretroviral agents
HIV Vaccine
antiretroviral
prenatal
  • 66 views
  • 25 Jan, 2021
  • 1 location
Pharmacokinetics of Antiretroviral Agents in HIV-infected Pregnant Women.

Due to the potential for pregnancy-induced changes in the pharmacokinetics of medication, one cannot assume that the currently licensed doses of the medication to be tested under this protocol lead to adequate exposure in an HIV-infected pregnant woman. For the agents under study no or limited pharmacokinetic data during pregnancy …

antiretroviral
hiv antibody
antiretroviral agents
immune globulin
HIV Vaccine
  • 156 views
  • 25 Mar, 2021
  • 25 locations
Dolutegravir/Rilpivirine Antiretroviral Efficacy Study Using Real-world Data in Subjects With Human Immunodeficiency Virus (HIV)-1

This is a prospective, non-interventional, single-arm, multi-center study aimed at gathering real-world data on Juluca use in routine clinical care in Germany, to supplement clinical trial data to further improve/optimize care in HIV positive subjects in Germany. Approximately 250 virologically suppressed HIV positive subjects on stable antiretroviral therapy (ART) will …

antiretroviral agents
HIV Vaccine
antiretroviral therapy
dolutegravir
antiretroviral
  • 10 views
  • 24 Jan, 2021
  • 12 locations
'COMBINE-2': Real-world Evidence for Effectiveness of Two Drug Regimen Antiretroviral Therapy With Integrase Inhibitors Plus a Reverse Transcriptase Inhibitor

Dolutegravir (DTG) is a well-tolerated 2nd generation integrase strand transfer inhibitor (INSTI); rilpivirine (RPV) is a well-tolerated non- nucleoside reverse transcriptase inhibitors (NNRTI

antiretroviral therapy
antiretroviral
dolutegravir
reverse transcriptase inhibitor
antiretroviral agents
  • 0 views
  • 24 Jan, 2021
  • 1 location