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Found 12 clinical trials
An Enhanced Package of Care to Reduce Reduce Mortality in Advanced HIV Disease (ENCORE)

A community-based Phase III, cluster randomized trial that seeks to determine the 24 week survival with retention in care of point of care CD4 testing with visitect and an enhanced package of screening and prophylaxis for opportunistic infections among patients with advanced HIV disease.

  • 0 views
  • 27 Jul, 2022
  • 1 location
Treatment of Latent Tuberculosis in Socially Marginalised Citizens

isoniazid for 6 months or weekly rifapentine and isoniazid as directly observed therapy for twelve weeks.

  • 0 views
  • 05 Aug, 2021
  • 2 locations
Assessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBI (ASTERoiD)

This study is conducted to compare the safety and effectiveness of a novel short 6-week regimen of daily rifapentine (6wP, experimental arm) with a comparator arm of 12-16 weeks of rifamycin

rifampin
interferon-gamma release assay
x-rays
interferon
chest x-ray
  • 38 views
  • 27 Jul, 2022
  • 1 location
Tuberculosis Preventive Therapy Among Latent Tuberculosis Infection in HIV-infected Individuals

investigators hypothesize that short-course (4-week) daily isoniazid/rifapentine (INH/RPT) (1HP) is not inferior to standard -course (12 weeks) INH/RPT weekly regimen (3HP) for the prevention of TB in human

  • 0 views
  • 13 Apr, 2022
  • 1 location
Community Initiated Preventive Therapy for TB

WHO recently endorsed the use of a new TPT regimen (rifapentine and isoniazid weekly (3HP)) for both children and adults in high burden settings, and the programmatic roll out of this regimen offers

  • 0 views
  • 21 Sep, 2021
  • 1 location
Clofazimine- and Rifapentine-Containing Treatment Shortening Regimens in Drug-Susceptible Tuberculosis: The CLO-FAST Study

The purpose of this study is to compare a 3-month rifapentine (RPT)/clofazimine (CFZ)-containing regimen with CFZ loading dose versus 6-month standard of care (SOC) for drug-susceptible (DS

HIV Vaccine
hysterectomy
hiv-1 rna measurement
antibody test
antiretroviral therapy
  • 0 views
  • 10 May, 2022
  • 2 locations
Impact of Weekly Administration of Rifapentine and Isoniazid on Steady State Pharmacokinetics of Tenofovir Alafenamide in Healthy Volunteers (YODA)

. Objective To study if rifapentine and isoniazid affect blood levels of the common antiretroviral TAF. Eligibility Healthy

Accepts healthy volunteers
blood test
fasting
cervical cap
vitamins
  • 9 views
  • 26 Jul, 2022
  • 1 location
Tuberculosis Clinical Trials Consortium Study 35

Hypotheses: Rifapentine (given as water-dispersible monolayer and/or fixed dose combination with isoniazid) dosing in HIV-infected and uninfected children 12 years of age with latent TB

rifampin
interferon-gamma release assay
Accepts healthy volunteers
mycobacterium tuberculosis
elisa
  • 2 views
  • 24 Feb, 2022
  • 1 location
Risk of SDRs Under 3HP and 1HP Regimen for LTBI

weekly high-dose (15 mg/kg) rifapentine plus isoniazid (3HP regimen), the completion rate of 3HP has be shown to be much higher than 9H. However, 4.9% to 9.1% of LTBI cases who received 3HP failed to

isoniazid
skin test
rifapentine
smear
tuberculin test
  • 11 views
  • 29 Oct, 2021
  • 1 location
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings (HARAPAN II)

infection prevention strategies among HIV+ and HIV- prisoners with high prevalence of hepatitis C (HCV) using standard 40-week daily isoniazid (40H) vs short-course weekly isoniazid + rifapentine (12HR

opioid dependence
x-rays
latent tuberculosis
naltrexone
isoniazid
  • 34 views
  • 06 Jun, 2022
  • 1 location