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Found 22 clinical trials
Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis

patients received antituberculosis treatment, which consisted of isoniazid (standard dose or high dose), rifampin, pyrazinamide, ethambutol for 3 months, followed by isoniazid, rifampin and ethambutol at

  • 0 views
  • 05 Feb, 2021
  • 4 locations
A New Treatment for Primary Smear-positive Pulmonary Tuberculosis With Interleukin-2

The purpose of the study is to compare the efficacy and safety of standard chemotherapy regimen 2HRZE/4HR plus IL-2 and standard regimen 2HRZE/4HR for newly diagnosed smear positive pulmonary tuberculosis.

  • 0 views
  • 28 Feb, 2021
  • 16 locations
Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB

The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M. tuberculosis (MTB) with or without rifampin

direct microscopy
acid-fast bacilli
rifampin
neutrophil count
platelet count
  • 16 views
  • 24 Jan, 2021
  • 1 location
A Study of Steady-state Rifampin on the Single-dose of Erdafitinib Tablets in Healthy Adult Participants

The main purpose of this study is to evaluate the effect of multiple doses of rifampin (a strong inducer of CYP3A4 and a moderate inducer of CYP2C9) on the pharmacokinetics of a single oral dose

  • 0 views
  • 27 Jan, 2021
  • 1 location
A Pilot Study of Inflammatory Markers in Alzheimer's Disease

and rifampin. The results of this preliminary analysis will be used in defining the direction of further research.

neuropsychological test
  • 163 views
  • 07 Nov, 2020
  • 1 location
Assessing PA-824 for Tuberculosis (the APT Trial)

Assess the mycobactericidal activity of PA-824 (given at 200 mg daily) when added to first-line tuberculosis (TB) treatment (isoniazid, pyrazinamide, and a rifamycin antibiotic) over 12 weeks of treatment. Funding Source - FDA OOPD

pyrazinamide
pa-824
smear
acid-fast bacilli
rifamycin
  • 198 views
  • 25 Jan, 2021
  • 1 location
Enhanced Bioscaffold for Volumetric Muscle Loss

This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix AB Surgical Graft in the restoration of function in the setting of volumetric muscle loss after soft tissue trauma.

  • 0 views
  • 27 Jan, 2021
  • 1 location
2R2: Higher Dose Rifampin for 2 Months vs Standard Dose Rifampin for Latent TB.

Rationale Shorter regimens of high dose daily rifampin may be safe, and as effective as the standard rifampin regimen when taken for 4 months to treat latent TB

skin test
interferon
tuberculin test
pulmonary tuberculosis
interferon-gamma release assay
  • 1 views
  • 24 Jan, 2021
  • 6 locations
Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics

The purpose of this research study is to determine if rifampin, an antibiotic (a medicine that treats infections), is effective in treating osteomyelitis (infection of the bone) of the foot in

hemoglobin a1c
antibiotics
riboflavin
diabetic foot
antibiotic therapy
  • 513 views
  • 18 Feb, 2021
  • 30 locations
Assessment of the Safety Tolerability and Effectiveness of Rifapentine Given Daily for LTBI

and rifampin (3HR), and 16 weeks of daily rifampin (4R). A total of 560 participants per arm (1,120 total) for the evaluation of safety and 1,700 participants per arm (3,400 total) for the evaluation

co-infections
tnf-alpha
nucleic acid amplification test
pulmonary tuberculosis
interferon-gamma release assay
  • 16 views
  • 24 Jan, 2021
  • 7 locations