rifampin Clinical Research Trials

Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis

patients received antituberculosis treatment, which consisted of isoniazid (standard dose or high dose), rifampin, pyrazinamide, ethambutol for 3 months, followed by isoniazid, rifampin and ethambutol at

0 views
05 Feb, 2021
4 locations

A New Treatment for Primary Smear-positive Pulmonary Tuberculosis With Interleukin-2

The purpose of the study is to compare the efficacy and safety of standard chemotherapy regimen 2HRZE/4HR plus IL-2 and standard regimen 2HRZE/4HR for newly diagnosed smear positive pulmonary tuberculosis.

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28 Feb, 2021
16 locations

Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB

The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M. tuberculosis (MTB) with or without rifampin

direct microscopy

acid-fast bacilli

rifampin

neutrophil count

platelet count

16 views
24 Jan, 2021
1 location

A Study of Steady-state Rifampin on the Single-dose of Erdafitinib Tablets in Healthy Adult Participants

The main purpose of this study is to evaluate the effect of multiple doses of rifampin (a strong inducer of CYP3A4 and a moderate inducer of CYP2C9) on the pharmacokinetics of a single oral dose

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27 Jan, 2021
1 location

A Pilot Study of Inflammatory Markers in Alzheimer's Disease

and rifampin. The results of this preliminary analysis will be used in defining the direction of further research.

neuropsychological test

163 views
07 Nov, 2020
1 location

Assessing PA-824 for Tuberculosis (the APT Trial)

Assess the mycobactericidal activity of PA-824 (given at 200 mg daily) when added to first-line tuberculosis (TB) treatment (isoniazid, pyrazinamide, and a rifamycin antibiotic) over 12 weeks of treatment. Funding Source - FDA OOPD

pyrazinamide

pa-824

smear

acid-fast bacilli

rifamycin

198 views
25 Jan, 2021
1 location

Enhanced Bioscaffold for Volumetric Muscle Loss

This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix AB Surgical Graft in the restoration of function in the setting of volumetric muscle loss after soft tissue trauma.

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27 Jan, 2021
1 location

2R2: Higher Dose Rifampin for 2 Months vs Standard Dose Rifampin for Latent TB.

Rationale Shorter regimens of high dose daily rifampin may be safe, and as effective as the standard rifampin regimen when taken for 4 months to treat latent TB

skin test

interferon

tuberculin test

pulmonary tuberculosis

interferon-gamma release assay

1 views
24 Jan, 2021
6 locations

Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics

The purpose of this research study is to determine if rifampin, an antibiotic (a medicine that treats infections), is effective in treating osteomyelitis (infection of the bone) of the foot in

hemoglobin a1c

antibiotics

riboflavin

diabetic foot

antibiotic therapy

513 views
18 Feb, 2021
30 locations

Assessment of the Safety Tolerability and Effectiveness of Rifapentine Given Daily for LTBI

and rifampin (3HR), and 16 weeks of daily rifampin (4R). A total of 560 participants per arm (1,120 total) for the evaluation of safety and 1,700 participants per arm (3,400 total) for the evaluation

co-infections

tnf-alpha

nucleic acid amplification test