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Found 23 clinical trials
Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB

The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M. tuberculosis (MTB) with or without rifampin

acid-fast bacilli
direct microscopy
platelet count
rifampin
amoxicillin
  • 16 views
  • 22 Oct, 2021
  • 1 location
PK Study to Assess Drug-drug Interaction Between Sitravatinib and a P-gp Inducer and an Inhibitor.

A Phase 1 Open-label, Two-cohort, One-sequence Crossover Study to Investigate the Effect of P glycoprotein Inhibitor (Itraconazole) and Inducer (Rifampin) on the Pharmacokinetics, Safety, and

Accepts healthy volunteers
  • 0 views
  • 16 Mar, 2022
Adjunctive Linezolid for the Treatment of Tuberculous Meningitis

This is a phase II randomized open-label trial of high versus standard dose rifampin (RIF) with or without linezolid (LZD) for the first 4 weeks of treatment for Tuberculosis Meningitis (TBM) at

  • 0 views
  • 17 Jun, 2021
  • 1 location
Enhanced Bioscaffold for Volumetric Muscle Loss (MTEC VML)

This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix™ AB Surgical Graft in the restoration of function in the setting of volumetric muscle loss after soft tissue trauma.

  • 0 views
  • 27 Feb, 2022
  • 1 location
2R2: Higher Dose Rifampin for 2 Months vs Standard Dose Rifampin for Latent TB. (2R2)

Rationale Shorter regimens of high dose daily rifampin may be safe, and as effective as the standard rifampin regimen when taken for 4 months to treat latent TB

interferon
tuberculin test
rifampin
interferon-gamma release assay
pulmonary tuberculosis
  • 1 views
  • 20 Feb, 2022
  • 5 locations
Investigation of Rifampin to Reduce Pedal Amputations for Osteomyelitis in Diabetics (VA INTREPID)

The purpose of this research study is to determine if rifampin, an antibiotic (a medicine that treats infections), is effective in treating osteomyelitis (infection of the bone) of the foot in

antibiotic therapy
oral hypoglycemic
riboflavin
rifampin
a hemoglobin
  • 631 views
  • 24 May, 2022
  • 25 locations
Assessment of the Safety, Tolerability, and Effectiveness of Rifapentine Given Daily for LTBI (ASTERoiD)

and rifampin (3HR), and 16 weeks of daily rifampin (4R). A total of 560 participants per arm (1,120 total) for the evaluation of safety and 1,700 participants per arm (3,400 total) for the evaluation

chest x-ray
tnf-alpha
rifampin
interferon-gamma release assay
isoniazid
  • 38 views
  • 14 Feb, 2022
  • 6 locations
Rapid Research in Diagnostics Development for TB Network (R2D2TB Network)

To reduce the burden of TB worldwide through more accurate, faster, simpler, and less expensive diagnosis of TB Every year, more than 3 million people with TB remain undiagnosed and 1 million die. Better diagnostics are essential to reducing the enormous burden of TB worldwide. The Rapid Research in Diagnostics …

  • 10 views
  • 22 Mar, 2022
  • 11 locations
Rifampin in CYP24A1-related Hypercalcemia and Hypercalciuria (RICHH)

This study evaluates the efficacy of rifampin in the treatment of hypercalcemia and/or hypercalciuria in participants with biallelic inactivating mutations of the CYP24A1 gene. Eligible subjects

rifampin
calcium
  • 57 views
  • 10 Mar, 2022
  • 1 location
Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)

also takes metformin. Participants will have a chance to be put on either: 1) standard TB medicines (isoniazid, rifampicin, ethambutol and pyrazinamide for two months, continuing isoniazid and rifampin

antibiotics
drug levels
drug level
immunodeficiency
HIV Vaccine
  • 0 views
  • 23 Sep, 2021
  • 1 location