Found 24 clinical trials
Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis
patients received antituberculosis treatment, which consisted of isoniazid (standard dose or high dose), rifampin, pyrazinamide, ethambutol for 3 months, followed by isoniazid, rifampin and ethambutol at
- 0 views
- 05 Feb, 2021
- 4 locations
A New Treatment for Primary Smear-positive Pulmonary Tuberculosis With Interleukin-2
The purpose of the study is to compare the efficacy and safety of standard chemotherapy regimen 2HRZE/4HR plus IL-2 and standard regimen 2HRZE/4HR for newly diagnosed smear positive pulmonary tuberculosis.
- 0 views
- 04 Mar, 2021
- 16 locations
Early Bactericidal Activity of Rifampin + Meropenem + Amoxicillin/Clavulanate in Adults With Pulmonary TB
The overall goal of this exploratory proof-of-concept study is to determine whether, in participants with pulmonary tuberculosis caused by M. tuberculosis (MTB) with or without rifampin
- 16 views
- 24 Jan, 2021
- 1 location
Drug-drug Interaction Study of CTP-543 and Rifampin in Healthy Adult Subjects
This is a Phase 1 open-label study of the effect of rifampin on the pharmacokinetics of CTP-543 in healthy subjects.
- 0 views
- 04 Jun, 2021
- 1 location
Study to Evaluate the Effects of Itraconazole and Rifampin on the Pharmacokinetics of ASC40 in Healthy Subjects
The primary objective of this study is to evaluate the effects of itraconazole (a strong inhibitor of cytochrome P450 3A (CYP3A)) and rifampicin (a strong inducer of CYP3A) on the pharmacokinetics of ASC40 in healthy volunteers.
- 0 views
- 21 Apr, 2021
- 1 location
A Pilot Study of Inflammatory Markers in Alzheimer's Disease
and rifampin. The results of this preliminary analysis will be used in defining the direction of further research.
- 163 views
- 07 Nov, 2020
- 1 location
Adjunctive Linezolid for the Treatment of Tuberculous Meningitis
This is a phase II randomized open-label trial of high versus standard dose rifampin (RIF) with or without linezolid (LZD) for the first 4 weeks of treatment for Tuberculosis Meningitis (TBM) at
- 0 views
- 13 Jun, 2021
- 1 location
Assessing PA-824 for Tuberculosis (the APT Trial)
Assess the mycobactericidal activity of PA-824 (given at 200 mg daily) when added to first-line tuberculosis (TB) treatment (isoniazid, pyrazinamide, and a rifamycin antibiotic) over 12 weeks of treatment. Funding Source - FDA OOPD
- 198 views
- 01 Apr, 2021
- 1 location
Enhanced Bioscaffold for Volumetric Muscle Loss
This is a prospective, single center study conducted at the University of Pittsburgh designed to test the applicability and utility of XenMatrix AB Surgical Graft in the restoration of function in the setting of volumetric muscle loss after soft tissue trauma.
- 0 views
- 27 Jan, 2021
- 1 location
2R2: Higher Dose Rifampin for 2 Months vs Standard Dose Rifampin for Latent TB.
Rationale Shorter regimens of high dose daily rifampin may be safe, and as effective as the standard rifampin regimen when taken for 4 months to treat latent TB
- 1 views
- 24 Jan, 2021
- 6 locations