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Found 198 clinical trials
The BENeFiTS Trial in Beta Thalassemia Intermedia

ribonucleic acid (mRNA) to high levels in anemic nonhuman primates and in transgenic mice. The study drug acts by suppressing 4 repressors of the fetal globin gene promoter in progenitor cells from patients

thalassemia
  • 0 views
  • 02 Jun, 2021
  • 4 locations
Prospective Cohort of Patients With Newly Diagnosed Glioblastoma: Analysis of MMP2 and MMP9 Expression and Correlation to Neuro-imaging Features.

angiogenesis while MMP9 could promote vasculogenesis. The objectives are to correlate the plasma levels of MMP2 and MMP9 to their Ribonucleic acid (RNA) and protein tissue expression, activity and to

vascular endothelial growth factor
temozolomide
MRI
VEGFR2
bevacizumab
  • 1 views
  • 22 Jan, 2021
  • 2 locations
The POWER BARIATRIC Trial: Physical Outcomes With Exercise Regimens on BARIATRIC Patients

mass, will be measured by a Dual-energy X-ray absorptiometry (DEXA); microbiota composition and changes will be evaluated by stool samples that will be subjected to 16S ribosomal ribonucleic acid (16s

bariatric surgery
fasting
fats
body mass index
  • 0 views
  • 22 Aug, 2021
  • 1 location
Nivolumab in Treating Patients With Autoimmune Disorders and Advanced Metastatic or Unresectable Cancer

This phase Ib trial studies the side effects of nivolumab and to see how well it works in treating patients with autoimmune disorders and cancer that has spread to other places in the body or cannot removed by surgery. Immunotherapy with monoclonal antibodies, such as nivolumab, may help the body's …

glomerular filtration rate
MRI
hysterectomy
monoclonal antibodies
diabetes
  • 619 views
  • 22 Sep, 2021
  • 30 locations
Rifaximin in Patients With Monoclonal Gammopathy

This trial studies how well rifaximin works in treating patients with monoclonal gammopathy. Antibiotics, such as rifaximin, may help to kill bacteria in the intestines and reduce the abnormal protein or cells in patients with monoclonal gammopathy.

multiple myeloma
antibiotics
  • 13 views
  • 26 Jan, 2021
  • 1 location
Ketoconazole in Treating Participants With Ongoing EGFR Inhibitor-Induced Rash

This early phase I trial studies the side effects of ketoconazole and how well it works in treating participants with ongoing EGFR inhibitor-induced rash. Ketoconazole may reduce the symptoms related to EGFR inhibitor therapy and improve EGFR inhibitor-induced rash.

skin biopsy
egfr inhibitor
EGFR
burning
  • 10 views
  • 28 Jun, 2021
  • 4 locations
Effects of Continuous Treatment With Rifaximin and Probiotics on the Gut Microbiota of Patients With IBS-D

We will use the latest Rome IV criteria to recruit IBS-D patients and evaluate the effects of repeated treatment with rifaximin and sequential treatment with rifaximin and probiotics on different symptoms and quality of life. High-throughput sequencing combined with real-time quantitative PCR will be used to comprehensively analyze the effects …

diarrhea
rifaximin
microbiota
  • 104 views
  • 24 Jan, 2021
  • 1 location
Balance Rehabilitation With Modified Visual Input in Patients With Neuropathy

This research focuses on the effects of rehabilitation on balance, in patients with acquired chronic demyelinating neuropathy. Rehabilitation will be performed with or without vision. It is planned to include 40 subjects consulting for walking instability related to sensitivity disorders. This multicenter study will take place in Paris's area. Each …

neuropathy
  • 25 views
  • 24 Jan, 2021
Leflunomide for the Treatment of Relapsed or Refractory CD30+ Lymphoproliferative Disorders

This trial studies how well leflunomide works for the treatment of patients with CD30+ lymphoproliferative disorders that have come back (relapsed) or do not respond to treatment (refractory). Leflunomide may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth.

  • 0 views
  • 21 Aug, 2021
  • 1 location
Interrogating Biological Signaling Pathway Dysregulations and In Vitro Screening With Personalized Therapies in Relapsed or Refractory Mantle Cell Lymphoma MCL MATCH Trial

This clinical trial collects and tests samples using genetic testing to find personalized treatments that may work best for patients with mantle cell lymphoma (MCL) that has come back (relapsed) or does not respond to treatment (refractory). Several types of MCL are difficult to treat due to specific genetic changes …

  • 0 views
  • 14 May, 2021
  • 1 location