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Found 183 clinical trials
Adavosertib Before Surgery in Treating Patients With Advanced High Grade Ovarian Fallopian Tube or Primary Peritoneal Cancer

This pilot early phase I trial studies how adavosertib affects the tumor deoxyribonucleic acid (DNA) of patients undergoing surgery for high grade (fast growing or aggressive) ovarian, fallopian tube, or primary peritoneal cancer that has spread to other places in the body (advanced). Certain characteristics in the DNA of these …

levonorgestrel
adavosertib
primary peritoneal carcinoma
vomiting
absolute neutrophil count
  • 0 views
  • 25 Jan, 2021
  • 9 locations
Phase I Trial of Adjuvant Pembrolizumab After Radiation Therapy for Lung-Intact Malignant Pleural Mesothelioma

This phase I trial studies the side effects and best way to give pembrolizumab after radiation therapy in treating patients with pleural malignant mesothelioma. Radiation therapy uses high energy radiation to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system …

metastasis
pneumonectomy
measurable disease
liver metastasis
carboplatin
  • 64 views
  • 23 Jan, 2021
  • 2 locations
Durvalumab With or Without Metformin in Treating Participants With Head and Neck Squamous Cell Carcinoma

This pilot phase I trial studies how well durvalumab given with or without metformin works in treating participants with head and neck squamous cell carcinoma. Monoclonal antibodies, such as durvalumab, may interfere with the ability of tumor cells to grow and spread. Metformin, a drug typically used for the treatment …

squamous cell carcinoma
follicle stimulating hormone
squamous cell carcinoma of the head and neck
solid tumors
neutrophil count
  • 5 views
  • 26 Jan, 2021
  • 1 location
A Study to Evaluate the Safety and Tolerability of QR-1123 in Subjects With Autosomal Dominant Retinitis Pigmentosa Due to the P23H Mutation in the RHO Gene

This study evaluates the safety, tolerability and efficacy of QR-1123 injection in the eye (intravitreal; IVT) injections (one eye/unilateral) in subjects receiving a single dose or repeat doses. Single injections will be assessed in an open label way, and repeat injections will be assessed in a double-masked, randomized, sham-controlled fashion.

pupil dilation
mydriasis
retinitis
  • 49 views
  • 26 Jan, 2021
  • 6 locations
Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases

This phase I trial studies the side effects and how well papaverine hydrochloride and stereotactic radiation therapy body (SBRT) work in treating patients with non-small cell lung cancer. Papaverine hydrochloride may help radiation therapy work better by making tumor cells more sensitive to the radiation therapy. Stereotactic body radiation therapy …

solid tumour
metastasis
stereotactic body radiation therapy
ct scan
  • 0 views
  • 15 Feb, 2021
  • 1 location
Nelfinavir Cisplatin and External Beam Radiation Therapy for the Treatment of Locally Advanced Vulvar Cancer That Cannot Be Removed by Surgery

This phase I trial studies the side effects and best dose of nelfinavir when given together with cisplatin and external beam radiation therapy in treating patients with vulvar cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be removed by surgery. Nelfinavir is an antiviral …

  • 0 views
  • 25 Jan, 2021
Ixazomib and Rituximab in Treating Patients With Relapsed or Refractory Mantle Cell Lymphoma

This phase II trial studies how well ixazomib and rituximab work in treating patients with mantle cell lymphoma that has come back (relapsed) or does not respond (refractory) to BTK inhibitor treatment. Ixazomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. …

refractory mantle cell lymphoma
btk inhibitor
measurable disease
rituximab
gilbert's syndrome
  • 1 views
  • 24 Jan, 2021
  • 1 location
Alpelisib in Treating Participants With Transorally Resectable HPV-Associated Stage I-IVA Oropharyngeal Cancer

This phase II trial studies how well alpelisib works in treating participants with human papillomavirus(HPV)-associated stage I-IVA head and neck cancer that can be removed by surgery. Alpelisib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

  • 0 views
  • 27 Jan, 2021
  • 1 location
Effects of Curcumin Supplementation in Patients With Chronic Kidney Disease on Peritoneal Dialysis

The objective of this study is to assess whether supplementation with curcumin could modulate the intestinal microbiota, reducing levels of inflammatory markers of oxidative stress, uremic toxins and inflammasome, in patients with chronic kidney disease in peritoneal dialysis.

  • 0 views
  • 26 Jan, 2021
  • 1 location
Ellagic Acid Urolithin and Colonic Microbial Communities Affected by Walnut Consumption

Briefly, this is a 28-day dietary intervention study participants will be asked to eat 2 ounces (52 grams) of walnuts every day for 3 weeks, and at the end of the study period they will come in for a colonoscopy. Participants will first start a 1-week run-in period where they …

  • 0 views
  • 25 Mar, 2021
  • 1 location