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Found 188 clinical trials
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

brain metastases
palliative radiation therapy
  • 25 Jul, 2021
  • 1019 locations
Standard of Care Therapy With or Without Stereotactic Radiosurgery and/or Surgery in Treating Patients With Limited Metastatic Breast Cancer

This randomized phase II/III trial studies how well standard of care therapy with stereotactic radiosurgery and/or surgery works and compares it to standard of care therapy alone in treating patients with breast cancer that has spread to one or two locations in the body (limited metastatic) that are previously untreated. …

ct scan
biomarker analysis
computed tomography
neutrophil count
absolute neutrophil count
  • 09 Jun, 2021
  • 84 locations
OPTimizing Irradiation Through Molecular Assessment of Lymph Node (OPTIMAL)

The main purpose of this study is to show the non-inferiority of the incidental irradiation, as compared to intentional irradiation of the axillary nodes, in terms of 5-years disease-free survival (DFS) of early stage breast cancer patients with limited affectation of sentinel node assessed by OSNA (250 to 15,000 copies/uL), …

axillary lymph node dissection
female breast cancer
sentinel node
ductal carcinoma
  • 23 Jan, 2021
  • 87 locations
Combination Chemotherapy With or Without Atezolizumab in Treating Patients With Stage III Colon Cancer and Deficient DNA Mismatch Repair

This phase III trial studies combination chemotherapy and atezolizumab to see how well it works compared with combination chemotherapy alone in treating patients with stage III colon cancer and deficient deoxyribonucleic acid (DNA) mismatch repair. Drugs used in combination chemotherapy, such as oxaliplatin, leucovorin calcium, and fluorouracil, work in different …

hiv viral load
pulmonary disease
absolute neutrophil count
  • 25 Jul, 2021
  • 589 locations
Active Surveillance Bleomycin Carboplatin Etoposide or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors

This phase III trial studies how well active surveillance, bleomycin, carboplatin, etoposide, or cisplatin work in treating pediatric and adult patients with germ cell tumors. Active surveillance may help doctors to monitor subjects with low risk germ cell tumors after their tumor is removed. Drugs used in chemotherapy, such as …

neutrophil count
platelet count
  • 25 Jul, 2021
  • 369 locations
CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy

This trial studies how well paclitaxel, trastuzumab, and pertuzumab work in eliminating further chemotherapy after surgery in patients with HER2-positive stage II-IIIa breast cancer who have no cancer remaining at surgery (either in the breast or underarm lymph nodes) after pre-operative chemotherapy and HER2-targeted therapy. Drugs used in chemotherapy, such …

neutrophil count
ejection fraction
progesterone receptor
  • 26 Jul, 2021
  • 577 locations
Impact of the Immune System on Response to Anti-Coronavirus Disease 19 (COVID-19) Vaccine in Allogeneic Stem Cell Recipients (Covid Vaccin Allo)

The present study is a prospective phase IV study. All participants will receive the anti-Coronavirus Disease 2019 (COVID-19) Vaccine (messenger Ribonucleic acid-based vaccine, BNT162b2 or

cell transplantation
  • 13 Jul, 2021
  • 1 location
A Study to Evaluate the Effectiveness and Safety of IONIS-FB-LRx an Antisense Inhibitor of Complement Factor B in Adult Participants With Primary IgA Nephropathy

The purpose of this study is to evaluate the effectiveness and safety of IONIS-FB-LRx, an antisense inhibitor of complement factor B messenger ribonucleic acid (CFB mRNA), and to evaluate the

  • 23 Jun, 2021
  • 6 locations
Predictive Value of 10 microRNA in Thyroid Cytologies of Undetermined Type

The aim is to validate a signature of 10 microRNA (micro Ribonucleic acid) selected in a first exploratory study allowing the stratification of the cytologies of indeterminate type (In a first

  • 01 Jul, 2021
  • 2 locations
Skeletal Muscle Expression of Myostatin and Cancer of Digestive System Associated Cachexia

cachexia in patients with cancer of digestive system. The main objective is to compare skeletal muscle Myostatin messenger RiboNucleic Acid (mRNA) level as a function of cachexia in cancer of digestive

digestive system cancer
  • 26 Jan, 2021
  • 2 locations