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Found 183 clinical trials
Doravirine/Islatravir (DOR/ISL) in Heavily Treatment-Experienced (HTE) Participants for Human Immunodeficiency Virus Type 1 (HIV-1) Infection (MK-8591A-019)

/ISL to achieve 0.5 log10 decrease in HIV-1 ribonucleic acid (RNA) from study baseline (Day 1) to Day 8 is superior to placebo, each given in combination with failing antiretroviral therapy (ART).

  • 117 views
  • 28 Mar, 2021
  • 100 locations
OPTimizing Irradiation Through Molecular Assesment of Lymph Node After Primary Systemic Treatment

ribonucleic acid (mRNA) in the sentinel node. The result is expressed by the Tumour Load as number of copies per microliter. This technique has shown its diagnostic ability both without primary systemic

sentinel node
female breast cancer
invasive breast cancer
core needle biopsy
mastectomy
  • 0 views
  • 23 Jan, 2021
  • 22 locations
A Dose-Range Finding Clinical Trial Study in Human Immunodeficiency Virus (HIV-1) Infected Treatment-Naive Adults

last participant completes their Week 48 study visit (Week 48 Secondary Endpoint study milestone). Thereafter, participants whose most recent HIV-1 ribonucleic acid (RNA) less than (<)50 copies

  • 0 views
  • 11 Apr, 2021
  • 44 locations
Total Therapy XVII for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia and Lymphoma

therapy, including incorporation of targeted agents and institution of genetic counseling and cancer surveillance. To evaluate and implement deoxyribonucleic acid (DNA) and ribonucleic acid (RNA

thioguanine
flow cytometry
lymphoma
methotrexate
cyclophosphamide
  • 230 views
  • 29 Jan, 2021
  • 7 locations
PRO-MERIT (Prostate Cancer Messenger RNA Immunotherapy)

Open-label, multicenter, dose titration and four-arm expansion trial to evaluate the safety, tolerability, immunogenicity, and preliminary efficacy of W_pro1 cancer vaccine (W_pro1) monotherapy or in combination with cemiplimab in patients with metastatic castration resistant prostate cancer (mCRPC: Part 1 and Part 2 Arms 1A and 1B) and in patients with …

docetaxel
abiraterone
cancer vaccine
serum testosterone
adenocarcinoma
  • 57 views
  • 11 Apr, 2021
  • 23 locations
A Study of Switching to RPV Plus Other ARVs in HIV-1-infected Children (Aged 2 to <12 Years) Who Are Virologically Suppressed

The purpose of this study is to evaluate the steady state pharmacokinetics (PK) of rilpivirine (RPV) and determine the appropriate dose of RPV in combination with other antiretrovirals (ARVs) in participants aged greater than or equal to 2 to less than 12 years and to evaluate the safety and tolerability …

immunodeficiency
integrase inhibitors
tenofovir
dolutegravir
HIV Infection
  • 53 views
  • 26 Jan, 2021
  • 19 locations
A Study of Rilematovir in Infants and Children and Subsequently in Neonates Hospitalized With Acute Respiratory Tract Infection Due to Respiratory Syncytial Virus (RSV)

The purpose of the study is to evaluate the efficacy of rilematovir compared to placebo treatment with respect to the clinical outcome on the RSV Recovery Scale (RRS).

  • 0 views
  • 26 Mar, 2021
  • 203 locations
Whole Genome Trio Sequencing as a Standard Routine Test in Patients With Rare Diseases - "GENOME FIRST APPROACH"

The GENOME FIRST APPROACH project will enroll patients (n = 450) and their healthy parents with unclear molecular cause of the disease, suspected genetic cause of the disease and the healthy parents of those affected for trio analysis (N in total 1350).

  • 0 views
  • 27 Jan, 2021
  • 1 location
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic …

gilbert's syndrome
dolutegravir
major surgery
bone marrow procedure
ct scan
  • 6087 views
  • 11 Apr, 2021
  • 1002 locations
Platinum Based Chemotherapy or Capecitabine in Treating Patients With Residual Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant Chemotherapy

This randomized phase III trial studies how well cisplatin or carboplatin (platinum based chemotherapy) works compared to capecitabine in treating patients with remaining (residual) basal-like triple-negative breast cancer following chemotherapy after surgery (neoadjuvant). Drugs used in chemotherapy, such as cisplatin, carboplatin and capecitabine, work in different ways to stop the …

lobular carcinoma in situ
sentinel node
metastasis
carboplatin
invasive breast cancer
  • 508 views
  • 24 Jan, 2021
  • 703 locations