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Found 537 clinical trials
A TWINSS Extension Trial to Evaluate the Safety and Tolerability of CFZ533 (Iscalimab) at Two Dose Levels Administered Subcutaneously in Patients With Sjögren's Syndrome (TWINSS Extn)

This study will evaluate the safety and tolerability of iscalimab at two dose levels in patients with Sjögren's Syndrome, who participated in the TWINSS core study, CCFZ533B2201(NCT03905525). Additionally, this Extension study will further explore the pharmacokinetics (PK) and efficacy of iscalimab at two dose level.

  • 28 Oct, 2022
  • 45 locations
A Randomized, Double-blind, Placebo-controlled, Parallel-group Study of the Safety, Tolerability, Pharmacokinetics, and Therapeutic Efficacy of SAR441344 in Adult Patients With Primary Sjögren's Syndrome (pSjS) (phaethuSA)

Primary Objective: To evaluate the therapeutic efficacy of one dose level of SAR441344 versus placebo over 12 weeks in adult patients with primary Sjögren's syndrome (pSjS), assessed by the change of the European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease Activity Index (ESSDAI) Secondary Objectives: To evaluate the therapeutic efficacy …

  • 28 Oct, 2022
  • 39 locations
Determination of the Frequency of Restless Legs Syndrome and Associated Factors in People With Neuromyelitis Optica Spectrum Disorder

, neuropathies, rheumatoid arthritis, parkinson's disease, spinocerebellar ataxia, and neurological disorders such as multiple sclerosis. Neuromyelitis optica (NMO) is a severe inflammatory disease of the

  • 25 Oct, 2022
  • 1 location
  • 25 Oct, 2022
  • 19 locations
Tivanisiran for Dry Eye in Subjects With Sjögren's Syndrome

This study will examine the efficacy and safety of tivanisiran sodium eye drops versus vehicle after a 2-week run-in phase when dosed once daily for 3 months in subjects with signs and symptoms of dry eye disease (DED) due to Sjögren's Syndrome.

  • 18 Oct, 2022
  • 30 locations
Objective Measurement With TCM Pattern for AIDDES

To explore the association with TCM pattern and TCM tongue diagnosis for Autoimmune disease and Dry eye syndrome.

  • 13 May, 2021
  • 1 location
The Impact of DNA Repair Pathway Alterations Identified by Circulating Tumor DNA on Sensitivity to Radium-223 in Bone Metastatic Castration-Resistant Prostate Cancer

This phase II study investigates how well radium-223 works in treating patients with castration-resistant prostate cancer than has spread to the bones (bone metastases). Prostate cancer is the most common cancer in men and the second leading cause of cancer death. Furthermore, many men with notably advanced disease have been …

dna damage
castration-resistant prostate cancer
prostate specific antigen
  • 27 Oct, 2022
  • 3 locations
The Need for Repeat ERCP After Endoscopic Treatment of Postsurgical Biliary Leaks

Post-surgical biliary leaks are relatively common after surgeries associated with hepatobiliary health. Left untreated, biliary leaks can lead to significant morbidity. Biliary leaks are most often successfully managed endoscopically, by way of performing an ERCP (endoscopic retrograde cholangio-pancreatography) procedure. These procedures help manage the bile leak by decreasing pressure at …

  • 08 Dec, 2021
  • 1 location
Kinematics of Silastic Joint Replacements in the Hand

To assess in vivo the kinematics of single piece silastic joint replacements in the hand with magnetic resonance imaging

Accepts healthy volunteers
joint replacement
  • 04 Oct, 2022
  • 1 location
Effects of Sarilumab on Interleukin 6 Levels in Critically Ill COVID-19 Patients

Investigate the possible effects of interleukin-6 receptor antagonists such as tocilizumab and sarilumab on the levels of IL-6 before and after treatment in critically ill corona virus disease-19 patients. Correlate between IL-6 levels with other inflammatory markers as ferritin and C-reactive protein.

  • 25 Oct, 2022
  • 1 location