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Found 163 clinical trials
Echocardiographic Screening of Pregnant Women During Antenatal Care

Non-obstetrical drivers of adverse pregnancy outcomes are underappreciated. Latent structural heart disease may account for a substantial proportion of adverse pregnancy outcomes in low-resource settings. Pregnant women presenting to B.P. Koirala Institute of Health Sciences will be prospectively included into a registry upon their visit for antenatal care. Women will …

prenatal
heart disease
  • 0 views
  • 29 Dec, 2021
  • 1 location
A Multi-center, Randomized, Double-blind, Placebo-controlled Phase 3 Study to Evaluate the Efficacy and Safety of Deucravacitinib in Participants With Active Psoriatic Arthritis (PsA) Who Are Naïve to Biologic Disease Modifying Anti-rheumatic Drugs or Had Previously Received TNFα Inhibitor Treatment

The purpose of this study is to evaluate the safety and efficacy of deucravacitinib versus placebo for the treatment of participants with active PsA who are naïve to biologic disease modifying antirheumatic drugs or had previously received TNFα inhibitor treatment.The long term extension period will provide additional long-term safety and …

arthritis
high sensitivity
plaque psoriasis
skin lesion
biological drug
  • 1 views
  • 11 Oct, 2022
  • 107 locations
The SARS-CoV-2 Vaccine Response and Safety in Rheumatology Patients and the Influence of Temporary Interruptions in Immunomodulatory Therapy (COVER)

., booster). Participants in this study will be men and women 18 years and older with confirmed rheumatic disease, including psoriatic arthritis (PsA), axial spondyloarthritis (SpA) and rheumatoid arthritis

  • 0 views
  • 15 Oct, 2022
  • 4 locations
Long-term Safety and Efficacy of GSK3196165 (Otilimab) in the Treatment of Rheumatoid Arthritis (RA) (contRAst X)

]). Participants will continue to receive the same background conventional synthetic disease modifying anti-rheumatic drug(s) [csDMARD(s)] treatment as they received in their qualifying study. Eligible

folate
rheumatic diseases
methotrexate
folic acid
autoimmune disease
  • 290 views
  • 04 Oct, 2022
  • 217 locations
Post Cardiac Valvular Surgery Rehabilitation (PORT)

The incidence of adult rheumatic valvular heart disease is 2.34% to 2.72% in China. Although guidelines or consensus recommendations recommend rehabilitation after valve surgery, clinical

walk test
valvular disease
rehabilitation program
valvular surgery
educational intervention
  • 16 views
  • 15 Feb, 2022
  • 1 location
A Study of Ralinepag to Evaluate Effects on Exercise Capacity by CPET in Subjects With WHO Group 1 PH (CAPACITY)

Study ROR-PH-302, ADVANCE CAPACITY, is designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after 28 weeks of treatment

endothelin receptor antagonist
ralinepag
exercise stress test
diuretics
cardiopulmonary exercise testing
  • 4 views
  • 04 Oct, 2022
  • 36 locations
Safety, Tolerability, Pharmacokinetics, and Therapeutic Efficacy of SAR441344 in Primary Sjögren's Syndrome (pSjS) (phaethuSA)

the change of the European League Against Rheumatism (EULAR) Sjögren's Syndrome Disease Activity Index (ESSDAI) Secondary Objectives: To evaluate the therapeutic efficacy of one

  • 114 views
  • 07 Oct, 2022
  • 39 locations
COVID-19 Booster Vaccine in Autoimmune Disease Non-Responders

This is a randomized, multi-site, adaptive, open-label clinical trial comparing the immune response to different additional doses of COVID-19 vaccine in participants with autoimmune disease requiring immunosuppressive medications. All study participants will have negative serologic or sub-optimal responses (defined as a Roche Elecsys® Anti-SARS-CoV-2 S (RBD) result ≤ 200 U/mL) …

prednisone
disease or disorder
mycophenolate
pulmonary disease
methotrexate
  • 79 views
  • 04 Oct, 2022
  • 20 locations
A Study to Evaluate the Efficacy and Safety of VIB4920 in Participants With Sj gren's Syndrome

The purpose of the study is to evaluate the efficacy, safety, and tolerability of VIB4920 (formerly MEDI4920) in adult participants with Sjgren's Syndrome (SS).

  • 342 views
  • 07 Oct, 2021
  • 55 locations
Health-Enhancing Adapted Physical Activity Program at "Mon Stade" (SESAME)

Introduction: Regular practice of exercise or physical activity (PA) is a recognized intervention as a determinant of good health acquisition, maintenance, or recovery for a large number of chronic pathologies. Nevertheless, few studies have evaluated adherence to an initial health-adapted PA (APA) program, and persistence of active behavior over the …

Accepts healthy volunteers
  • 0 views
  • 27 Apr, 2022
  • 1 location